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IID00342
 UniprotO60573
ProteinEukaryotic translation initiation factor 4E type 2
GeneEIF4E2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
245
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 45-234 Hetero dimer : IID00170Complex
 Evidence X-RAY 2jgc A Reference
       Region 2jgc A 45-46 disorder
       Region 2jgc A 47-71 order
       Region 2jgc A 72-79 disorder
       Region 2jgc A 80-219 order
       Region 2jgc A 220-227 disorder
       Region 2jgc A 228-234 order
 Evidence X-RAY 2jgb A Reference
       Region 2jgb A 45-224 order
       Region 2jgb A 225-227 disorder
       Region 2jgb A 228-234 order
Seq 52-234 Hetero tetramer : Q6Y7W6
 Evidence X-RAY 5nvm C Reference
       Region 5nvm C 52-67 order
       Region 5nvm C 68-79 disorder
       Region 5nvm C 80-219 order
       Region 5nvm C 220-234 disorder
 Evidence X-RAY 5nvm A Reference
       Region 5nvm A 52-221 order
       Region 5nvm A 222-234 disorder
Seq 52-234 Hetero tetramer : IID00170Complex
 Evidence X-RAY 5nvn C Reference
       Region 5nvn C 52-67 order
       Region 5nvn C 68-80 disorder
       Region 5nvn C 81-224 order
       Region 5nvn C 225-234 disorder
 Evidence X-RAY 5nvn A Reference
       Region 5nvn A 52-66 order
       Region 5nvn A 67-80 disorder
       Region 5nvn A 81-224 order
       Region 5nvn A 225-234 disorder
Seq 52-234 Hetero tetramer : Q6Y7W6
 Evidence X-RAY 5nvl C Reference
       Region 5nvl C 52-68 order
       Region 5nvl C 69-80 disorder
       Region 5nvl C 81-218 order
       Region 5nvl C 219-234 disorder
 Evidence X-RAY 5nvl A Reference
       Region 5nvl A 52-69 order
       Region 5nvl A 70-78 disorder
       Region 5nvl A 79-218 order
       Region 5nvl A 219-234 disorder
Seq 52-234 Hetero octamer : O75420
 Evidence X-RAY 5nvk G Reference
       Region 5nvk G 52-69 order
       Region 5nvk G 70-80 disorder
       Region 5nvk G 81-233 order
       Region 5nvk G 234-234 disorder
 Evidence X-RAY 5nvk E Reference
       Region 5nvk E 52-219 order
       Region 5nvk E 220-234 disorder
 Evidence X-RAY 5nvk C Reference
       Region 5nvk C 52-219 order
       Region 5nvk C 220-234 disorder
 Evidence X-RAY 5nvk A Reference
       Region 5nvk A 52-69 order
       Region 5nvk A 70-78 disorder
       Region 5nvk A 79-232 order
       Region 5nvk A 233-234 disorder
Seqphosphorylation
    13-13 Phosphoserine
Seqacetylation
    134-134 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-50,239-245
Order 51-238
ProS 1-10,239-245
AlphaFold
Disorder 1-44,223-245
Order 45-222
Pfam Hmmer
PF01652 18-237 2.6e-132
Function
Function in SwissProt
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:17368478, PubMed:25624349, PubMed:9582349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). In P-bodies, component of a complex that promotes miRNA-mediated translational repression (PubMed:28487484).