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IID00343
 UniprotQ96BD6
ProteinSPRY domain-containing SOCS box protein 1
GeneSPSB1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
273
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 30-231 Hetero dimer : IID00177Complex
 Evidence X-RAY 2jk9 A Reference
       Region 2jk9 A 30-231 order
Seq 31-233 Hetero dimer : P09052
 Evidence X-RAY 3f2o B Reference
       Region 3f2o B 31-233 order
 Evidence X-RAY 3f2o A Reference
       Region 3f2o A 31-233 order
Seqphosphorylation
    31-31 Phosphotyrosine; by MET
 
Prediction
NeProc
Disorder 1-19
Order 20-273
ProS 1-12
AlphaFold
Disorder 1-9,17-30
Order 10-16,31-273
Pfam Hmmer
PF00622 95-230 1.5e-25
PF07525 234-273 8.2e-16
Function
Function in SwissProt
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876).