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IID00346
UniprotQ9GZQ8
ProteinMicrotubule-associated proteins 1A/1B light chain 3B
GeneMAP1LC3B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
125
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-119 Hetero dimer : Q5ZUV9
 Evidence X-RAY 5ms2 B Reference
       Region 5ms2 B 1-4 disorder
       Region 5ms2 B 5-119 order
Seq 1-120 Hetero dimer : Q8IVP5
 Evidence NMR 2n9x A Reference
       Region 2n9x A 1-120 order
       Region 2n9x A 120-120 high_rmsd
Seq 1-120 Monomer :
 Evidence NMR 1v49 A Reference
       Region 1v49 A 1-120 order
 Evidence X-RAY 3vtu A Reference
       Region 3vtu A 2-119 order
 Evidence X-RAY 3x0w A Reference
       Region 3x0w A 2-118 order
       Region 3x0w A 119-119 disorder
 Evidence X-RAY 3x0w B Reference
       Region 3x0w B 2-118 order
       Region 3x0w B 119-119 disorder
 Evidence X-RAY 5dcn A Reference
       Region 5dcn A 2-119 order
 Evidence X-RAY 5ms6 A Reference
       Region 5ms6 A 2-3 disorder
       Region 5ms6 A 4-117 order
       Region 5ms6 A 118-119 disorder
 Evidence X-RAY 5ms6 B Reference
       Region 5ms6 B 2-2 disorder
       Region 5ms6 B 3-117 order
       Region 5ms6 B 118-119 disorder
Seq 1-125 Hetero dimer : Q8IVP5
 Evidence X-RAY 5gmv A Reference
       Region 5gmv A 1-4 disorder
       Region 5gmv A 5-124 order
       Region 5gmv A 125-125 disorder
 Evidence X-RAY 5gmv B Reference
       Region 5gmv B 1-4 disorder
       Region 5gmv B 5-124 order
       Region 5gmv B 125-125 disorder
Seq 1-125 Hetero tetramer : IID50150Complex
 Evidence X-RAY 2zjd A Reference
       Region 2zjd A 1-1 disorder
       Region 2zjd A 2-122 order
       Region 2zjd A 123-125 disorder
 Evidence X-RAY 2zjd C Reference
       Region 2zjd C 1-122 order
       Region 2zjd C 123-125 disorder
Seq 1-125 Hetero dimer : Q9BQS8
 Evidence X-RAY 5d94 A Reference
       Region 5d94 A 1-4 disorder
       Region 5d94 A 5-123 order
       Region 5d94 A 124-125 disorder
Seq 2-119 Monomer : O75143
 Evidence X-RAY 3wao A Reference
       Region 3wao A 2-119 order
Seq 2-119 Monomer : IID00348Complex
 Evidence X-RAY 3vtw C Reference
       Region 3vtw C 2-119 order
Seq 2-119 Monomer : O75143
 Evidence X-RAY 3wao B Reference
       Region 3wao B 2-117 order
       Region 3wao B 118-119 disorder
Seq 2-119 Homo dimer :
 Evidence X-RAY 4waa A Reference
       Region 4waa A 2-118 order
       Region 4waa A 119-119 disorder
 Evidence X-RAY 4waa B Reference
       Region 4waa B 2-118 order
       Region 4waa B 119-119 disorder
 Evidence X-RAY 5v4k A Reference
       Region 5v4k A 2-118 order
       Region 5v4k A 119-119 disorder
 Evidence X-RAY 5v4k B Reference
       Region 5v4k B 2-117 order
       Region 5v4k B 118-119 disorder
Seq 2-119 Monomer : IID00348Complex
 Evidence X-RAY 3vtv A Reference
       Region 3vtv A 2-119 order
Seq 2-119 Monomer : O75143
 Evidence X-RAY 3wao C Reference
       Region 3wao C 2-117 order
       Region 3wao C 118-119 disorder
Seq 2-119 Monomer : IID00348Complex
 Evidence X-RAY 3vtw A Reference
       Region 3vtw A 2-119 order
Seq 2-119 Monomer : Q5ZUV9
 Evidence X-RAY 5ms5 B Reference
       Region 5ms5 B 2-3 disorder
       Region 5ms5 B 4-118 order
       Region 5ms5 B 119-119 disorder
Seq 2-119 Monomer : O75143
 Evidence X-RAY 3wao D Reference
       Region 3wao D 2-118 order
       Region 3wao D 119-119 disorder
Seq 2-119 Monomer : Q5ZUV9
 Evidence X-RAY 5ms5 A Reference
       Region 5ms5 A 2-3 disorder
       Region 5ms5 A 4-117 order
       Region 5ms5 A 118-119 disorder
Seq 2-119 Monomer : IID00348Complex
 Evidence X-RAY 3vtw B Reference
       Region 3vtw B 2-119 order
Seq 2-120 Homo tetramer :
 Evidence X-RAY 5xac A Reference
       Region 5xac A 2-118 order
       Region 5xac A 119-120 disorder
 Evidence X-RAY 5xac B Reference
       Region 5xac B 2-84 order
       Region 5xac B 85-87 disorder
       Region 5xac B 88-118 order
       Region 5xac B 119-120 disorder
 Evidence X-RAY 5xac C Reference
       Region 5xac C 2-72 order
       Region 5xac C 73-77 disorder
       Region 5xac C 78-116 order
       Region 5xac C 117-120 disorder
 Evidence X-RAY 5xac D Reference
       Region 5xac D 2-119 order
       Region 5xac D 120-120 disorder
 Evidence X-RAY 5xae A Reference
       Region 5xae A 2-87 order
       Region 5xae A 88-90 disorder
       Region 5xae A 91-119 order
       Region 5xae A 120-120 disorder
 Evidence X-RAY 5xae B Reference
       Region 5xae B 2-87 order
       Region 5xae B 88-92 disorder
       Region 5xae B 93-119 order
       Region 5xae B 120-120 disorder
 Evidence X-RAY 5xae C Reference
       Region 5xae C 2-119 order
       Region 5xae C 120-120 disorder
 Evidence X-RAY 5xae D Reference
       Region 5xae D 2-119 order
       Region 5xae D 120-120 disorder
Seq 2-120 Hetero dimer : Q5ZUV9
 Evidence X-RAY 5xad A Reference
       Region 5xad A 2-118 order
       Region 5xad A 119-120 disorder
 Evidence X-RAY 5xad B Reference
       Region 5xad B 2-120 order
Seq 5-119 Hetero dimer : IID00348Complex
 Evidence NMR 2lue A Reference
       Region 2lue A 5-119 order
 
Prediction
NeProc
Disorder 1-6
Order 7-89,95-125
AlphaFold
Disorder 1-3,121-125
Order 4-120
Pfam Hmmer
PF02991 15-120 8.8e-70
Function
Function in SwissProt
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:28017329). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).
Biological Process
See also
Diagram with PDB data
OPTN/MAP1LC3BLC3B OPTN-LIR Ptot complex structure