IID00346
Uniprot Q9GZQ8
Protein Microtubule-associated proteins 1A/1B light chain 3B
Gene MAP1LC3B
Organism Homo sapiens
Sequence
LLPS
Network
xml
rdf
Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
125
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 1-119 Hetero dimer : Q5ZUV9
Region 5ms2 B 1-4 disorder
Region 5ms2 B 5-119 order
Seq 1-120 Hetero dimer : Q8IVP5
Region 2n9x A 1-120 order
Region 2n9x A 120-120 high_rmsd
Region 1v49 A 1-120 order
Region 3vtu A 2-119 order
Region 3x0w A 2-118 order
Region 3x0w A 119-119 disorder
Region 3x0w B 2-118 order
Region 3x0w B 119-119 disorder
Region 5dcn A 2-119 order
Region 5ms6 A 2-3 disorder
Region 5ms6 A 4-117 order
Region 5ms6 A 118-119 disorder
Region 5ms6 B 2-2 disorder
Region 5ms6 B 3-117 order
Region 5ms6 B 118-119 disorder
Seq 1-125 Hetero dimer : Q8IVP5
Region 5gmv A 1-4 disorder
Region 5gmv A 5-124 order
Region 5gmv A 125-125 disorder
Region 5gmv B 1-4 disorder
Region 5gmv B 5-124 order
Region 5gmv B 125-125 disorder
Seq 1-125 Hetero tetramer : IID50150 Complex
Region 2zjd A 1-1 disorder
Region 2zjd A 2-122 order
Region 2zjd A 123-125 disorder
Region 2zjd C 1-122 order
Region 2zjd C 123-125 disorder
Seq 1-125 Hetero dimer : Q9BQS8
Region 5d94 A 1-4 disorder
Region 5d94 A 5-123 order
Region 5d94 A 124-125 disorder
Region 3wao A 2-119 order
Seq 2-119 Monomer : IID00348 Complex
Region 3vtw C 2-119 order
Region 3wao B 2-117 order
Region 3wao B 118-119 disorder
Region 4waa A 2-118 order
Region 4waa A 119-119 disorder
Region 4waa B 2-118 order
Region 4waa B 119-119 disorder
Region 5v4k A 2-118 order
Region 5v4k A 119-119 disorder
Region 5v4k B 2-117 order
Region 5v4k B 118-119 disorder
Seq 2-119 Monomer : IID00348 Complex
Region 3vtv A 2-119 order
Region 3wao C 2-117 order
Region 3wao C 118-119 disorder
Seq 2-119 Monomer : IID00348 Complex
Region 3vtw A 2-119 order
Region 5ms5 B 2-3 disorder
Region 5ms5 B 4-118 order
Region 5ms5 B 119-119 disorder
Region 3wao D 2-118 order
Region 3wao D 119-119 disorder
Region 5ms5 A 2-3 disorder
Region 5ms5 A 4-117 order
Region 5ms5 A 118-119 disorder
Seq 2-119 Monomer : IID00348 Complex
Region 3vtw B 2-119 order
Seq 2-120 Homo tetramer :
Region 5xac A 2-118 order
Region 5xac A 119-120 disorder
Region 5xac B 85-87 disorder
Region 5xac B 88-118 order
Region 5xac B 119-120 disorder
Region 5xac C 73-77 disorder
Region 5xac C 78-116 order
Region 5xac C 117-120 disorder
Region 5xac D 2-119 order
Region 5xac D 120-120 disorder
Region 5xae A 88-90 disorder
Region 5xae A 91-119 order
Region 5xae A 120-120 disorder
Region 5xae B 88-92 disorder
Region 5xae B 93-119 order
Region 5xae B 120-120 disorder
Region 5xae C 2-119 order
Region 5xae C 120-120 disorder
Region 5xae D 2-119 order
Region 5xae D 120-120 disorder
Seq 2-120 Hetero dimer : Q5ZUV9
Region 5xad A 2-118 order
Region 5xad A 119-120 disorder
Region 5xad B 2-120 order
Seq 5-119 Hetero dimer : IID00348 Complex
Region 2lue A 5-119 order
Function
Function in SwissProt
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:28017329). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).
Biological Process
See also
Diagram with PDB data
OPTN/MAP1LC3B LC3B OPTN-LIR Ptot
complex structure