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IID00347
 UniprotQ9Y4P1
ProteinCysteine protease ATG4B
GeneATG4B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
393
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-353 Hetero dimer : IID50112Complex
 Evidence X-RAY 2z0d A Reference
       Region 2z0d A 1-4 disorder
       Region 2z0d A 5-186 order
       Region 2z0d A 187-217 disorder
       Region 2z0d A 218-288 order
       Region 2z0d A 289-293 disorder
       Region 2z0d A 294-339 order
       Region 2z0d A 340-344 disorder
       Region 2z0d A 345-353 order
 Evidence X-RAY 2z0e A Reference
       Region 2z0e A 1-3 disorder
       Region 2z0e A 4-186 order
       Region 2z0e A 187-217 disorder
       Region 2z0e A 218-288 order
       Region 2z0e A 289-293 disorder
       Region 2z0e A 294-353 order
 Evidence X-RAY 2zzp A Reference
       Region 2zzp A 1-5 disorder
       Region 2zzp A 6-186 order
       Region 2zzp A 187-217 disorder
       Region 2zzp A 218-288 order
       Region 2zzp A 289-293 disorder
       Region 2zzp A 294-342 order
       Region 2zzp A 343-344 disorder
       Region 2zzp A 345-353 order
Seq 1-393 Monomer :
 Evidence X-RAY 2cy7 A Reference
       Region 2cy7 A 1-4 disorder
       Region 2cy7 A 5-189 order
       Region 2cy7 A 190-216 disorder
       Region 2cy7 A 217-287 order
       Region 2cy7 A 288-290 disorder
       Region 2cy7 A 291-342 order
       Region 2cy7 A 343-346 disorder
       Region 2cy7 A 347-355 order
       Region 2cy7 A 356-361 disorder
       Region 2cy7 A 362-377 order
       Region 2cy7 A 378-393 disorder
 Evidence X-RAY 2d1i A Reference
       Region 2d1i A 1-9 disorder
       Region 2d1i A 10-190 order
       Region 2d1i A 191-215 disorder
       Region 2d1i A 216-373 order
       Region 2d1i A 374-393 disorder
 Evidence X-RAY 2d1i B Reference
       Region 2d1i B 1-9 disorder
       Region 2d1i B 10-190 order
       Region 2d1i B 191-215 disorder
       Region 2d1i B 216-373 order
       Region 2d1i B 374-393 disorder
Seq 384-393 Hetero tetramer : Q9H0R8
 Evidence X-RAY 5lxi C Reference
       Region 5lxi C 384-393 order
 Evidence X-RAY 5lxi E Reference
       Region 5lxi E 384-385 disorder
       Region 5lxi E 386-393 order
Seq 384-393 Hetero dimer : Q9H0R8
 Evidence X-RAY 5lxh E Reference
       Region 5lxh E 384-393 order
 Evidence X-RAY 5lxh F Reference
       Region 5lxh F 384-393 order
 Evidence X-RAY 5lxh G Reference
       Region 5lxh G 384-393 order
SeqProS verified 378-393 Hetero tetramer : Q9H0R8
       Region 5lxi C 384-393 order
       Region 5lxi E 386-393 order
       Region 2cy7 A 378-393 disorder
SeqProS verified 378-393 Hetero dimer : Q9H0R8
       Region 5lxh E 384-393 order
       Region 5lxh F 384-393 order
       Region 5lxh G 384-393 order
       Region 2cy7 A 378-393 disorder
Seqphosphorylation
    392-392 Phosphoserine
    383-383 Phosphoserine; by STK26
    316-316 Phosphoserine; by ULK1
    34-34 Phosphoserine; by PKB/AKT1 and PKB/AKT2
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-1,190-216,357-393
Order 2-189,217-339,344-356
ProS 190-216,357-365,374-393
AlphaFold
Disorder 1-5,187-216,357-369,371-393
Order 6-186,217-356,370-370
Pfam Hmmer
PF03416 36-337 7.4e-149
SEG 220-232 ,375-393
Function
Function in SwissProt
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.