Search Keyword:


Search option:


IID00349
 UniprotP61925
ProteincAMP-dependent protein kinase inhibitor alpha
GenePKIA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
76
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-76 Hetero trimer : IID50169Complex
 Evidence X-RAY 3wyg D Reference
       Region 3wyg D 1-32 disorder
       Region 3wyg D 33-52 order
       Region 3wyg D 53-76 disorder
Seq 1-76 Hetero hexamer : IID50169Complex
 Evidence X-RAY 5xoj D Reference
       Region 5xoj D 1-33 disorder
       Region 5xoj D 34-52 order
       Region 5xoj D 53-76 disorder
Seq 6-25 Hetero dimer : IID50134Complex
 Evidence X-RAY 4z83 I Reference
       Region 4z83 I 6-25 order
 Evidence X-RAY 1xha B Reference
       Region 1xha B 6-25 order
 Evidence X-RAY 1xh9 B Reference
       Region 1xh9 B 6-25 order
 Evidence X-RAY 1xh8 B Reference
       Region 1xh8 B 6-25 order
 Evidence X-RAY 1xh7 B Reference
       Region 1xh7 B 6-25 order
 Evidence X-RAY 1xh6 B Reference
       Region 1xh6 B 6-25 order
 Evidence X-RAY 1xh5 B Reference
       Region 1xh5 B 6-25 order
 Evidence X-RAY 1xh4 B Reference
       Region 1xh4 B 6-25 order
 Evidence X-RAY 2vo7 I Reference
       Region 2vo7 I 6-25 order
 Evidence X-RAY 2vo6 I Reference
       Region 2vo6 I 6-25 order
 Evidence X-RAY 2vo3 I Reference
       Region 2vo3 I 6-25 order
 Evidence X-RAY 2vo0 I Reference
       Region 2vo0 I 6-25 order
 Evidence X-RAY 2vny I Reference
       Region 2vny I 6-25 order
 Evidence X-RAY 2vnw I Reference
       Region 2vnw I 6-25 order
 Evidence X-RAY 4z84 I Reference
       Region 4z84 I 6-25 order
 Evidence X-RAY 1ydr I Reference
       Region 1ydr I 6-25 order
 Evidence X-RAY 1veb B Reference
       Region 1veb B 6-25 order
 Evidence X-RAY 2uw8 I Reference
       Region 2uw8 I 6-25 order
 Evidence X-RAY 2uw7 I Reference
       Region 2uw7 I 6-25 order
 Evidence X-RAY 2uw6 I Reference
       Region 2uw6 I 6-25 order
 Evidence X-RAY 2uw5 I Reference
       Region 2uw5 I 6-25 order
 Evidence X-RAY 2uw4 I Reference
       Region 2uw4 I 6-25 order
 Evidence X-RAY 2uw3 I Reference
       Region 2uw3 I 6-25 order
 Evidence X-RAY 2uw0 I Reference
       Region 2uw0 I 6-25 order
 Evidence X-RAY 2uvz I Reference
       Region 2uvz I 6-25 order
 Evidence X-RAY 2uvy I Reference
       Region 2uvy I 6-25 order
 Evidence X-RAY 2uvx I Reference
       Region 2uvx I 6-25 order
 Evidence X-RAY 1q8t B Reference
       Region 1q8t B 6-25 order
 Evidence X-RAY 2jdv I Reference
       Region 2jdv I 6-25 order
 Evidence X-RAY 2jdt I Reference
       Region 2jdt I 6-25 order
 Evidence X-RAY 2jds I Reference
       Region 2jds I 6-25 order
 Evidence X-RAY 4ij9 I Reference
       Region 4ij9 I 6-23 order
       Region 4ij9 I 24-25 disorder
 Evidence X-RAY 4ie9 I Reference
       Region 4ie9 I 6-25 order
 Evidence X-RAY 2gni I Reference
       Region 2gni I 6-25 order
 Evidence X-RAY 2f7e I Reference
       Region 2f7e I 6-25 order
 Evidence X-RAY 2c1b I Reference
       Region 2c1b I 6-25 order
 Evidence X-RAY 2c1a I Reference
       Region 2c1a I 6-25 order
 Evidence X-RAY 4axa I Reference
       Region 4axa I 6-25 order
Seq 6-25 Hetero dimer : IID00366Complex,IID00446Complex
 Evidence X-RAY 4wb7 I Reference
       Region 4wb7 I 6-25 order
Seq 6-25 Hetero dimer : IID00366Complex
 Evidence X-RAY 4wb8 I Reference
       Region 4wb8 I 6-25 order
 Evidence X-RAY 4wb6 J Reference
       Region 4wb6 J 6-25 order
 Evidence X-RAY 4wb6 I Reference
       Region 4wb6 I 6-24 order
       Region 4wb6 I 25-25 disorder
 Evidence X-RAY 4wb5 I Reference
       Region 4wb5 I 6-25 order
 Evidence X-RAY 3vqh B Reference
       Region 3vqh B 6-25 order
 Evidence X-RAY 4ujb B Reference
       Region 4ujb B 6-25 order
 Evidence X-RAY 4uja B Reference
       Region 4uja B 6-25 order
 Evidence X-RAY 4uj9 B Reference
       Region 4uj9 B 6-25 order
 Evidence X-RAY 4uj2 B Reference
       Region 4uj2 B 6-25 order
 Evidence X-RAY 4uj1 B Reference
       Region 4uj1 B 6-25 order
 Evidence X-RAY 3poo B Reference
       Region 3poo B 6-24 order
       Region 3poo B 25-25 disorder
 Evidence X-RAY 3p0m B Reference
       Region 3p0m B 6-24 order
       Region 3p0m B 25-25 disorder
 Evidence X-RAY 3oxt B Reference
       Region 3oxt B 6-23 order
       Region 3oxt B 24-25 disorder
 Evidence X-RAY 3owp B Reference
       Region 3owp B 6-24 order
       Region 3owp B 25-25 disorder
 Evidence X-RAY 3ovv B Reference
       Region 3ovv B 6-25 order
 Evidence X-RAY 3oog B Reference
       Region 3oog B 6-23 order
       Region 3oog B 24-25 disorder
 Evidence X-RAY 3nx8 B Reference
       Region 3nx8 B 6-23 order
       Region 3nx8 B 24-25 disorder
 Evidence X-RAY 5n23 B Reference
       Region 5n23 B 6-25 order
 Evidence X-RAY 3mvj I Reference
       Region 3mvj I 6-25 order
 Evidence X-RAY 3mvj K Reference
       Region 3mvj K 6-25 order
 Evidence X-RAY 3mvj J Reference
       Region 3mvj J 6-25 order
 Evidence X-RAY 3l9n C Reference
       Region 3l9n C 6-24 order
       Region 3l9n C 25-25 disorder
 Evidence X-RAY 3l9m D Reference
       Region 3l9m D 6-23 order
       Region 3l9m D 24-25 disorder
 Evidence X-RAY 3l9m C Reference
       Region 3l9m C 6-24 order
       Region 3l9m C 25-25 disorder
 Evidence X-RAY 3l9l D Reference
       Region 3l9l D 6-23 order
       Region 3l9l D 24-25 disorder
 Evidence X-RAY 3l9l C Reference
       Region 3l9l C 6-24 order
       Region 3l9l C 25-25 disorder
 Evidence X-RAY 5bx7 B Reference
       Region 5bx7 B 6-25 order
 Evidence X-RAY 5bx6 B Reference
       Region 5bx6 B 6-25 order
 Evidence X-RAY 3amb B Reference
       Region 3amb B 6-25 order
 Evidence X-RAY 3ama B Reference
       Region 3ama B 6-25 order
Seq 6-25 Hetero dimer : P25321
 Evidence X-RAY 5lcu B Reference
       Region 5lcu B 6-25 order
 Evidence X-RAY 5lct B Reference
       Region 5lct B 6-25 order
 Evidence X-RAY 5lcq B Reference
       Region 5lcq B 6-23 order
       Region 5lcq B 24-25 disorder
 Evidence X-RAY 5lcp B Reference
       Region 5lcp B 6-25 order
 Evidence X-RAY 5lcr B Reference
       Region 5lcr B 6-24 order
       Region 5lcr B 25-25 disorder
Seq 6-25 Hetero dimer : IID00366Complex,IID00446Complex
 Evidence X-RAY 4wb7 J Reference
       Region 4wb7 J 6-25 order
Seq 6-25 Hetero dimer : IID50138Complex
 Evidence X-RAY 3x2w S Reference
       Region 3x2w S 6-25 order
 Evidence X-RAY 3x2v S Reference
       Region 3x2v S 6-25 order
 Evidence X-RAY 3x2u S Reference
       Region 3x2u S 6-25 order
 Evidence X-RAY 4o22 S Reference
       Region 4o22 S 6-25 order
 Evidence X-RAY 4o21 S Reference
       Region 4o21 S 6-25 order
 Evidence X-RAY 1jlu S Reference
       Region 1jlu S 6-25 order
 Evidence X-RAY 4ib3 S Reference
       Region 4ib3 S 6-25 order
 Evidence X-RAY 4ib1 S Reference
       Region 4ib1 S 6-25 order
 Evidence X-RAY 4ib0 S Reference
       Region 4ib0 S 6-25 order
 Evidence X-RAY 4iaz S Reference
       Region 4iaz S 6-25 order
 Evidence X-RAY 4iay S Reference
       Region 4iay S 6-25 order
 Evidence X-RAY 4iak S Reference
       Region 4iak S 6-25 order
 Evidence X-RAY 4iai S Reference
       Region 4iai S 6-25 order
 Evidence X-RAY 4iaf S Reference
       Region 4iaf S 6-25 order
 Evidence X-RAY 4iad S Reference
       Region 4iad S 6-25 order
 Evidence X-RAY 4iac S Reference
       Region 4iac S 6-25 order
Seq 6-27 Hetero dodecamer : IID50158Complex
 Evidence X-RAY 1cmk I Reference
       Region 1cmk I 6-25 order
       Region 1cmk I 26-27 disorder
Seqdisorder 14-24
 Evidence CD Reference
       Region 14-24 disorder
Seq 30-54 Hetero dimer : IID00357Complex
 Evidence NMR 2l1l A Reference
       Region 2l1l A 30-54 order
       Region 2l1l A 30-32 high_rmsd
       Region 2l1l A 50-54 high_rmsd
Seq 36-46 Hetero tetramer : IID50169Complex
 Evidence X-RAY 5dh9 D Reference
       Region 5dh9 D 36-45 order
       Region 5dh9 D 46-46 disorder
SeqProS verified 6-25 Hetero dimer : IID50138Complex
       Region 4iad S 6-25 order
       Region 4iai S 6-25 order
       Region 4iac S 6-25 order
       Region 4iay S 6-25 order
       Region 4iaz S 6-25 order
       Region 1jlu S 6-25 order
       Region 4iaf S 6-25 order
       Region 4iak S 6-25 order
       Region 4ib0 S 6-25 order
       Region 4o22 S 6-25 order
       Region 4ib3 S 6-25 order
       Region 4o21 S 6-25 order
       Region 4ib1 S 6-25 order
       Region 3x2u S 6-25 order
       Region 3x2v S 6-25 order
       Region 3x2w S 6-25 order
       Region 3wyg D 1-32 disorder
SeqProS verified 6-25 Hetero dimer : IID00366Complex
       Region 3vqh B 6-25 order
       Region 3nx8 B 6-23 order
       Region 3amb B 6-25 order
       Region 3l9m C 6-24 order
       Region 3l9m D 6-23 order
       Region 3mvj I 6-25 order
       Region 3mvj J 6-25 order
       Region 3mvj K 6-25 order
       Region 3oxt B 6-23 order
       Region 3ovv B 6-25 order
       Region 3oog B 6-23 order
       Region 3owp B 6-24 order
       Region 3poo B 6-24 order
       Region 3l9n C 6-24 order
       Region 3p0m B 6-24 order
       Region 3ama B 6-25 order
       Region 3l9l C 6-24 order
       Region 3l9l D 6-23 order
       Region 4wb8 I 6-25 order
       Region 4wb6 I 6-24 order
       Region 4wb6 J 6-25 order
       Region 4wb5 I 6-25 order
       Region 4ujb B 6-25 order
       Region 4uj1 B 6-25 order
       Region 4uj9 B 6-25 order
       Region 4uj2 B 6-25 order
       Region 4uja B 6-25 order
       Region 3wyg D 1-32 disorder
SeqProS verified 6-25 Hetero dimer : IID00366Complex,IID00446Complex
       Region 4wb7 J 6-25 order
       Region 3wyg D 1-32 disorder
SeqProS verified 6-25 Hetero dodecamer : IID50158Complex
       Region 1cmk I 6-25 order
       Region 3wyg D 1-32 disorder
SeqProS verified 6-25 Hetero dimer : IID00366Complex,IID00446Complex
       Region 4wb7 I 6-25 order
       Region 3wyg D 1-32 disorder
SeqProS verified 6-25 Hetero dimer : IID50134Complex
       Region 2jds I 6-25 order
       Region 4axa I 6-25 order
       Region 1xh5 B 6-25 order
       Region 2vo0 I 6-25 order
       Region 2gni I 6-25 order
       Region 2uw0 I 6-25 order
       Region 2f7e I 6-25 order
       Region 2jdv I 6-25 order
       Region 1xh7 B 6-25 order
       Region 4ij9 I 6-23 order
       Region 2uvz I 6-25 order
       Region 2jdt I 6-25 order
       Region 2vo6 I 6-25 order
       Region 2uw4 I 6-25 order
       Region 2uvy I 6-25 order
       Region 1xh9 B 6-25 order
       Region 1xha B 6-25 order
       Region 2vo7 I 6-25 order
       Region 2c1a I 6-25 order
       Region 2uw3 I 6-25 order
       Region 2uw8 I 6-25 order
       Region 2vny I 6-25 order
       Region 4ie9 I 6-25 order
       Region 2vo3 I 6-25 order
       Region 1xh4 B 6-25 order
       Region 1q8t B 6-25 order
       Region 2uw7 I 6-25 order
       Region 1veb B 6-25 order
       Region 2uw5 I 6-25 order
       Region 2vnw I 6-25 order
       Region 1ydr I 6-25 order
       Region 2c1b I 6-25 order
       Region 2uvx I 6-25 order
       Region 1xh8 B 6-25 order
       Region 2uw6 I 6-25 order
       Region 1xh6 B 6-25 order
       Region 4z83 I 6-25 order
       Region 4z84 I 6-25 order
       Region 3wyg D 1-32 disorder
Seqacetylation
    2-2 N-acetylthreonine
 
Prediction
NeProc
Disorder 1-9,20-23,29-76
Order 10-19,24-28
ProS 5-9,20-23,35-50
AlphaFold
Disorder 1-1,15-34,51-76
Order 2-14,35-50
Pfam Hmmer
PF02827 2-75 3.2e-47
Function
Function in SwissProt
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.