IDEAL List

IDEAL

IID00350
UniprotP55854
ProteinSmall ubiquitin-related modifier 3
GeneSUMO3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

103

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 2-92 Hetero trimer : Q9QZS2

Evidence NMR 2mp2 B Reference

Region 2mp2 B 2-90 order

Evidence NMR 2mp2 A Reference

Region 2mp2 A 12-92 order

Region 2mp2 A 12-12 high_rmsd

Seq 14-92 Monomer :

Evidence NMR 1u4a A Reference

Region 1u4a A 14-92 order

Region 1u4a A 89-92 high_rmsd

Seq 14-103 Hetero dimer : Q9HC62

Evidence X-RAY 2io1 F Reference

Region 2io1 F 14-14 disorder

Region 2io1 F 15-95 order

Region 2io1 F 96-103 disorder

Evidence X-RAY 2io1 D Reference

Region 2io1 D 14-14 disorder

Region 2io1 D 15-96 order

Region 2io1 D 97-103 disorder

Evidence X-RAY 2io1 B Reference

Region 2io1 B 14-14 disorder

Region 2io1 B 15-95 order

Region 2io1 B 96-103 disorder

Prediction

NeProc

Disorder 1-14

Order 15-103

ProS 9-14

AlphaFold

Disorder 1-1,3-14,89-103

Order 2-2,15-88

Pfam Hmmer

PF00240 20-90 1.2e-12

Function

Function in SwissProt

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).