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IID00354
 UniprotP12643
ProteinBone morphogenetic protein 2
GeneBMP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
396
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 283-314 Homo dimer : IID00338Complex
 Evidence X-RAY 4mid A Reference
       Region 4mid A 283-291 disorder
       Region 4mid A 292-314 order
Seq 283-396 Hetero hexamer : IID50131Complex,P36894
 Evidence X-RAY 2h64 A Reference
       Region 2h64 A 283-291 disorder
       Region 2h64 A 292-396 order
Seq 283-396 Hetero octamer : P97798,Q6NW40
 Evidence X-RAY 4ui2 B Reference
       Region 4ui2 B 283-292 disorder
       Region 4ui2 B 293-396 order
Seq 283-396 Hetero dimer : Q6NW40
 Evidence X-RAY 4uhz A Reference
       Region 4uhz A 283-292 disorder
       Region 4uhz A 293-396 order
Seq 283-396 Hetero tetramer : P36894
 Evidence X-RAY 1rew B Reference
       Region 1rew B 283-293 disorder
       Region 1rew B 294-396 order
 Evidence X-RAY 1rew A Reference
       Region 1rew A 283-293 disorder
       Region 1rew A 294-396 order
 Evidence X-RAY 2qjb B Reference
       Region 2qjb B 283-292 disorder
       Region 2qjb B 293-396 order
 Evidence X-RAY 2qjb A Reference
       Region 2qjb A 283-293 disorder
       Region 2qjb A 294-396 order
 Evidence X-RAY 2qja B Reference
       Region 2qja B 283-292 disorder
       Region 2qja B 293-396 order
 Evidence X-RAY 2qja A Reference
       Region 2qja A 283-292 disorder
       Region 2qja A 293-396 order
 Evidence X-RAY 2qj9 B Reference
       Region 2qj9 B 283-293 disorder
       Region 2qj9 B 294-396 order
 Evidence X-RAY 2qj9 A Reference
       Region 2qj9 A 283-292 disorder
       Region 2qj9 A 293-396 order
 Evidence X-RAY 1es7 C Reference
       Region 1es7 C 283-292 disorder
       Region 1es7 C 293-396 order
 Evidence X-RAY 1es7 A Reference
       Region 1es7 A 283-292 disorder
       Region 1es7 A 293-396 order
Seq 283-396 Hetero trimer : Q96B86
 Evidence X-RAY 4uhy B Reference
       Region 4uhy B 283-291 disorder
       Region 4uhy B 292-396 order
 Evidence X-RAY 4uhy A Reference
       Region 4uhy A 283-292 disorder
       Region 4uhy A 293-396 order
Seq 283-396 Hetero tetramer : P36894,Q13705
 Evidence X-RAY 2h62 B Reference
       Region 2h62 B 283-293 disorder
       Region 2h62 B 294-396 order
 Evidence X-RAY 2h62 A Reference
       Region 2h62 A 283-292 disorder
       Region 2h62 A 293-396 order
Seq 283-305,362-396 Homo dimer : IID00577Complex
 Evidence X-RAY 4n1d A Reference
       Region 4n1d A 283-292 disorder
       Region 4n1d A 293-305 order
       Region 4n1d A 362-396 order
Seq 283-396 Hetero trimer : Q6NW40
 Evidence X-RAY 4ui0 B Reference
       Region 4ui0 B 283-292 disorder
       Region 4ui0 B 293-396 order
 Evidence X-RAY 4ui0 A Reference
       Region 4ui0 A 283-292 disorder
       Region 4ui0 A 293-332 order
       Region 4ui0 A 333-335 disorder
       Region 4ui0 A 336-396 order
Seq 283-396 Homo dimer :
 Evidence X-RAY 1reu A Reference
       Region 1reu A 294-396 order
 Evidence X-RAY 3bmp A As temperature factors are high at the pre-helix loop (residue number:330-335) in 3bmp, these regions are flexible. But that of 1rew are much lower. Probably because of complex formation, the segment becomes rigid. Reference
       Region 3bmp A 283-290 disorder
       Region 3bmp A 291-396 order
Seq 283-396 Hetero tetramer : IID50132Complex
 Evidence X-RAY 3bk3 B Reference
       Region 3bk3 B 283-292 disorder
       Region 3bk3 B 293-396 order
 Evidence X-RAY 3bk3 A Reference
       Region 3bk3 A 283-292 disorder
       Region 3bk3 A 293-396 order
Seq 283-396 Hetero hexamer : P27038,P36894
 Evidence X-RAY 2goo D Reference
       Region 2goo D 283-292 disorder
       Region 2goo D 293-396 order
 Evidence X-RAY 2goo A Reference
       Region 2goo A 283-293 disorder
       Region 2goo A 294-396 order
Seq 283-396 Hetero dimer : Q6ZVN8
 Evidence X-RAY 4ui1 B Reference
       Region 4ui1 B 283-291 disorder
       Region 4ui1 B 292-396 order
 Evidence X-RAY 4ui1 A Reference
       Region 4ui1 A 283-292 disorder
       Region 4ui1 A 293-396 order
Seqphosphorylation
    87-87 Phosphoserine
 
Prediction
NeProc
Disorder 1-6,30-47,91-99,248-258,264-294
Order 7-29,48-90,100-162,167-247,259-263,295-396
ProS 1-6,30-32,91-99,248-258,264-271
AlphaFold
Disorder 1-45,90-95,121-126,158-166,235-242,278-293
Order 46-89,96-120,127-157,167-234,243-277,294-396
Pfam Hmmer
PF00688 36-268 4.7e-91
PF00019 293-396 2.4e-66
SEG 8-29
Function
Function in SwissProt
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis (PubMed:18436533, PubMed:31019025, PubMed:24362451). Induces cartilage and bone formation (PubMed:3201241). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:15064755, PubMed:17295905, PubMed:18436533). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A (PubMed:7791754). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation (PubMed:20851880). Stimulates also the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451).