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IID00356
 UniprotO14686
ProteinHistone-lysine N-methyltransferase 2D
GeneKMT2D
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
5537
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 5333-5347 Hetero dimer : IID00377Complex
 Evidence X-RAY 3uvk B Reference
       Region 3uvk B 5337-5347 order
 Evidence X-RAY 4erq F Reference
       Region 4erq F 5333-5345 order
       Region 4erq F 5346-5346 disorder
 Evidence X-RAY 4erq E Reference
       Region 4erq E 5333-5345 order
       Region 4erq E 5346-5346 disorder
 Evidence X-RAY 4erq D Reference
       Region 4erq D 5333-5345 order
       Region 4erq D 5346-5346 disorder
Seq 5382-5536 Monomer :
 Evidence X-RAY 4z4p A Reference
       Region 4z4p A 5382-5536 order
Seqphosphorylation
    4849-4849 Phosphoserine
    4822-4822 Phosphoserine
    4738-4738 Phosphoserine
    4359-4359 Phosphoserine
    4215-4215 Phosphoserine
    3199-3199 Phosphoserine
    3197-3197 Phosphothreonine
    3130-3130 Phosphoserine
    2640-2640 Phosphoserine
    2342-2342 Phosphoserine
    2311-2311 Phosphoserine
    2309-2309 Phosphoserine
    2274-2274 Phosphoserine
    2260-2260 Phosphoserine
    2240-2240 Phosphothreonine
    2239-2239 Phosphoserine
    1865-1865 Phosphothreonine
    1843-1843 Phosphothreonine
    1834-1834 Phosphoserine
    1820-1820 Phosphoserine
    1671-1671 Phosphoserine
    1606-1606 Phosphoserine
    1270-1270 Phosphoserine
    1267-1267 Phosphothreonine
    1249-1249 Phosphoserine
    1195-1195 Phosphothreonine
    1151-1151 Phosphoserine
    744-744 Phosphoserine
    27-27 Phosphoserine
Seqacetylation
    4776-4776 N6-acetyllysine
    4465-4465 N6-acetyllysine
    3433-3433 N6-acetyllysine
    3079-3079 N6-acetyllysine
    2246-2246 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-60,94-107,363-369,374-1357,1565-2024,2059-2671,2711-3248,3277-3563,3613-3712,3748-3895,3976-4779,4819-4865,4879-5009,5349-5378
Order 61-93,108-362,370-373,1358-1564,2025-2049,2056-2058,2672-2710,3249-3276,3564-3612,3713-3747,3896-3975,4780-4789,4794-4818,4866-4878,5010-5348,5379-5537
ProS 363-369,374-395,401-409,425-428,436-444,452-456,1238-1242,1265-1268,1281-1286,1303-1309,1582-1604,1618-1626,1671-1683,1689-1713,1765-1785,1825-1828,1891-1898,1928-1933,1949-1955,2012-2024,2059-2063,2323-2328,2612-2615,2764-2773,2875-2882,2905-2909,3010-3074,3498-3542,3548-3563,4460-4468,4480-4486,4502-4509,4550-4556,4567-4581,4587-4609,4636-4653,4669-4678,4691-4728,4736-4755,4835-4865,4879-4879,4888-4905,4980-4998,5349-5356,5373-5378
Pfam Hmmer
PF00628 228-276 1.6e-12
PF00628 277-323 2.5e-12
PF00628 1379-1430 5.4e-11
PF00628 1431-1477 3.3e-11
PF00628 1506-1559 2.3e-05
PF05964 5180-5233 3.9e-20
PF05965 5236-5323 5.7e-36
PF00856 5391-5519 2.1e-49
SEG 95-105 ,134-148 ,374-386 ,430-483 ,488-736 ,842-871 ,875-954 ,993-1014 ,1034-1057 ,1104-1111 ,1281-1292 ,1303-1328 ,1351-1358 ,1558-1574 ,1611-1620 ,1633-1656 ,1678-1690 ,1751-1763 ,1974-1993 ,2107-2122 ,2190-2210 ,2349-2366 ,2377-2401 ,2409-2431 ,2445-2462 ,2489-2506 ,2545-2559 ,2589-2604 ,2607-2624 ,2676-2697 ,2707-2722 ,2767-2778 ,2810-2822 ,2862-2874 ,2887-2906 ,2930-2940 ,3085-3102 ,3198-3210 ,3252-3289 ,3301-3320 ,3367-3379 ,3599-3612 ,3631-3657 ,3676-3702 ,3715-3759 ,3783-3806 ,3856-3867 ,3872-3886 ,3897-3974 ,3988-3994 ,4012-4023 ,4073-4108 ,4112-4129 ,4209-4236 ,4252-4275 ,4277-4296 ,4300-4331 ,4548-4564 ,4610-4633 ,4694-4704 ,4826-4848 ,4906-4970 ,5049-5056 ,5494-5502
Function
Function in SwissProt
Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.