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IID00360
 UniprotO75164
ProteinLysine-specific demethylase 4A
GeneKDM4A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1064
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-350 Hetero dimer :
 Evidence X-RAY 2q8e A Reference
       Region 2q8e A 1-2 disorder
       Region 2q8e A 3-346 order
       Region 2q8e A 347-350 disorder
Seq 1-350 Hetero dimer :
 Evidence X-RAY 2q8d A Reference
       Region 2q8d A 1-347 order
       Region 2q8d A 348-350 disorder
Seq 1-350 Hetero dimer :
 Evidence X-RAY 2q8c B Reference
       Region 2q8c B 1-11 disorder
       Region 2q8c B 12-346 order
       Region 2q8c B 347-350 disorder
Seq 1-350 Hetero dimer :
 Evidence X-RAY 2q8d B Reference
       Region 2q8d B 1-8 disorder
       Region 2q8d B 9-346 order
       Region 2q8d B 347-350 disorder
Seq 1-350 Hetero dimer :
 Evidence X-RAY 2q8c A Reference
       Region 2q8c A 1-2 disorder
       Region 2q8c A 3-347 order
       Region 2q8c A 348-350 disorder
Seq 1-350 Hetero dimer :
 Evidence X-RAY 2q8e B Reference
       Region 2q8e B 1-8 disorder
       Region 2q8e B 9-345 order
       Region 2q8e B 346-350 disorder
Seq 1-359 Hetero trimer : IID00058Complex
 Evidence X-RAY 5fwe B Reference
       Region 5fwe B 1-2 disorder
       Region 5fwe B 3-355 order
       Region 5fwe B 356-359 disorder
 Evidence X-RAY 5fwe A Reference
       Region 5fwe A 1-6 disorder
       Region 5fwe A 7-354 order
       Region 5fwe A 355-359 disorder
Seq 1-359 Hetero dimer :
 Evidence X-RAY 2os2 A Reference
       Region 2os2 A 1-7 disorder
       Region 2os2 A 8-354 order
       Region 2os2 A 355-359 disorder
Seq 1-359 Homo dimer :
 Evidence X-RAY 2vd7 B Reference
       Region 2vd7 B 1-6 disorder
       Region 2vd7 B 7-355 order
       Region 2vd7 B 356-359 disorder
 Evidence X-RAY 2vd7 A Reference
       Region 2vd7 A 1-5 disorder
       Region 2vd7 A 6-355 order
       Region 2vd7 A 356-359 disorder
 Evidence X-RAY 5fyi B Reference
       Region 5fyi B 1-9 disorder
       Region 5fyi B 10-353 order
       Region 5fyi B 354-359 disorder
 Evidence X-RAY 5fyi A Reference
       Region 5fyi A 1-3 disorder
       Region 5fyi A 4-354 order
       Region 5fyi A 355-359 disorder
Seq 1-359 Hetero pentamer :
 Evidence X-RAY 5ly1 A Reference
       Region 5ly1 A 1-6 disorder
       Region 5ly1 A 7-355 order
       Region 5ly1 A 356-359 disorder
 Evidence X-RAY 5ly1 B Reference
       Region 5ly1 B 1-8 disorder
       Region 5ly1 B 9-354 order
       Region 5ly1 B 355-359 disorder
 Evidence X-RAY 5ly1 C Reference
       Region 5ly1 C 1-4 disorder
       Region 5ly1 C 5-161 order
       Region 5ly1 C 162-169 disorder
       Region 5ly1 C 170-354 order
       Region 5ly1 C 355-359 disorder
 Evidence X-RAY 5ly1 D Reference
       Region 5ly1 D 1-7 disorder
       Region 5ly1 D 8-354 order
       Region 5ly1 D 355-359 disorder
Seq 1-359 Hetero trimer : IID00086Complex
 Evidence X-RAY 4v2w A Reference
       Region 4v2w A 1-6 disorder
       Region 4v2w A 7-354 order
       Region 4v2w A 355-359 disorder
 Evidence X-RAY 4v2w B Reference
       Region 4v2w B 1-2 disorder
       Region 4v2w B 3-355 order
       Region 4v2w B 356-359 disorder
Seq 1-359 Homo tetramer :
 Evidence X-RAY 5ly2 D Reference
       Region 5ly2 D 1-7 disorder
       Region 5ly2 D 8-354 order
       Region 5ly2 D 355-359 disorder
 Evidence X-RAY 5ly2 C Reference
       Region 5ly2 C 1-4 disorder
       Region 5ly2 C 5-161 order
       Region 5ly2 C 162-169 disorder
       Region 5ly2 C 170-354 order
       Region 5ly2 C 355-359 disorder
 Evidence X-RAY 5ly2 B Reference
       Region 5ly2 B 1-9 disorder
       Region 5ly2 B 10-354 order
       Region 5ly2 B 355-359 disorder
 Evidence X-RAY 5ly2 A Reference
       Region 5ly2 A 1-6 disorder
       Region 5ly2 A 7-354 order
       Region 5ly2 A 355-359 disorder
Seq 1-359 Monomer :
 Evidence X-RAY 2ybk B Reference
       Region 2ybk B 1-6 disorder
       Region 2ybk B 7-355 order
       Region 2ybk B 356-359 disorder
 Evidence X-RAY 2ybk A Reference
       Region 2ybk A 1-6 disorder
       Region 2ybk A 7-355 order
       Region 2ybk A 356-359 disorder
 Evidence X-RAY 2wwj B Reference
       Region 2wwj B 7-353 order
 Evidence X-RAY 2wwj A Reference
       Region 2wwj A 7-7 disorder
       Region 2wwj A 8-353 order
 Evidence X-RAY 5vmp D Reference
       Region 5vmp D 5-165 order
       Region 5vmp D 166-170 disorder
       Region 5vmp D 171-309 order
       Region 5vmp D 310-312 disorder
       Region 5vmp D 313-353 order
       Region 5vmp D 354-354 disorder
 Evidence X-RAY 5vmp C Reference
       Region 5vmp C 5-11 disorder
       Region 5vmp C 12-111 order
       Region 5vmp C 112-113 disorder
       Region 5vmp C 114-309 order
       Region 5vmp C 310-313 disorder
       Region 5vmp C 314-336 order
       Region 5vmp C 337-338 disorder
       Region 5vmp C 339-354 order
 Evidence X-RAY 5vmp B Reference
       Region 5vmp B 5-309 order
       Region 5vmp B 310-312 disorder
       Region 5vmp B 313-354 order
 Evidence X-RAY 5vmp A Reference
       Region 5vmp A 5-309 order
       Region 5vmp A 310-312 disorder
       Region 5vmp A 313-354 order
 Evidence X-RAY 5vgi D Reference
       Region 5vgi D 5-8 disorder
       Region 5vgi D 9-353 order
       Region 5vgi D 354-354 disorder
 Evidence X-RAY 5vgi C Reference
       Region 5vgi C 5-8 disorder
       Region 5vgi C 9-161 order
       Region 5vgi C 162-169 disorder
       Region 5vgi C 170-353 order
       Region 5vgi C 354-354 disorder
 Evidence X-RAY 5vgi B Reference
       Region 5vgi B 5-8 disorder
       Region 5vgi B 9-353 order
       Region 5vgi B 354-354 disorder
 Evidence X-RAY 5vgi A Reference
       Region 5vgi A 5-8 disorder
       Region 5vgi A 9-353 order
       Region 5vgi A 354-354 disorder
 Evidence X-RAY 4ura B Reference
       Region 4ura B 1-9 disorder
       Region 4ura B 10-353 order
       Region 4ura B 354-359 disorder
 Evidence X-RAY 4ura A Reference
       Region 4ura A 1-3 disorder
       Region 4ura A 4-352 order
       Region 4ura A 353-359 disorder
 Evidence X-RAY 5tvs B Reference
       Region 5tvs B 1-5 disorder
       Region 5tvs B 6-353 order
       Region 5tvs B 354-359 disorder
 Evidence X-RAY 5tvs A Reference
       Region 5tvs A 1-5 disorder
       Region 5tvs A 6-353 order
       Region 5tvs A 354-359 disorder
 Evidence X-RAY 5tvr B Reference
       Region 5tvr B 1-6 disorder
       Region 5tvr B 7-352 order
       Region 5tvr B 353-359 disorder
 Evidence X-RAY 5tvr A Reference
       Region 5tvr A 1-5 disorder
       Region 5tvr A 6-353 order
       Region 5tvr A 354-359 disorder
 Evidence X-RAY 3rvh B Reference
       Region 3rvh B 1-4 disorder
       Region 3rvh B 5-354 order
       Region 3rvh B 355-359 disorder
 Evidence X-RAY 3rvh A Reference
       Region 3rvh A 1-2 disorder
       Region 3rvh A 3-353 order
       Region 3rvh A 354-359 disorder
 Evidence X-RAY 3pdq B Reference
       Region 3pdq B 1-6 disorder
       Region 3pdq B 7-354 order
       Region 3pdq B 355-359 disorder
 Evidence X-RAY 3pdq A Reference
       Region 3pdq A 1-2 disorder
       Region 3pdq A 3-355 order
       Region 3pdq A 356-359 disorder
 Evidence X-RAY 2oq7 B Reference
       Region 2oq7 B 1-6 disorder
       Region 2oq7 B 7-353 order
       Region 2oq7 B 354-359 disorder
 Evidence X-RAY 2oq7 A Reference
       Region 2oq7 A 1-8 disorder
       Region 2oq7 A 9-354 order
       Region 2oq7 A 355-359 disorder
 Evidence X-RAY 3njy B Reference
       Region 3njy B 1-7 disorder
       Region 3njy B 8-354 order
       Region 3njy B 355-359 disorder
 Evidence X-RAY 3njy A Reference
       Region 3njy A 1-7 disorder
       Region 3njy A 8-354 order
       Region 3njy A 355-359 disorder
 Evidence X-RAY 2gp5 B Reference
       Region 2gp5 B 2-9 disorder
       Region 2gp5 B 10-346 order
       Region 2gp5 B 347-350 disorder
 Evidence X-RAY 2gp5 A Reference
       Region 2gp5 A 2-348 order
       Region 2gp5 A 349-350 disorder
 Evidence X-RAY 2gp3 B Reference
       Region 2gp3 B 2-9 disorder
       Region 2gp3 B 10-348 order
       Region 2gp3 B 349-350 disorder
 Evidence X-RAY 2gp3 A Reference
       Region 2gp3 A 2-350 order
 Evidence X-RAY 4gd4 B Reference
       Region 4gd4 B 1-7 disorder
       Region 4gd4 B 8-354 order
       Region 4gd4 B 355-359 disorder
 Evidence X-RAY 4gd4 A Reference
       Region 4gd4 A 1-4 disorder
       Region 4gd4 A 5-354 order
       Region 4gd4 A 355-359 disorder
 Evidence X-RAY 5fyh B Reference
       Region 5fyh B 1-6 disorder
       Region 5fyh B 7-353 order
       Region 5fyh B 354-359 disorder
 Evidence X-RAY 5fyh A Reference
       Region 5fyh A 1-3 disorder
       Region 5fyh A 4-354 order
       Region 5fyh A 355-359 disorder
 Evidence X-RAY 5fyc B Reference
       Region 5fyc B 1-6 disorder
       Region 5fyc B 7-353 order
       Region 5fyc B 354-359 disorder
 Evidence X-RAY 5fyc A Reference
       Region 5fyc A 1-8 disorder
       Region 5fyc A 9-353 order
       Region 5fyc A 354-359 disorder
 Evidence X-RAY 5fy8 B Reference
       Region 5fy8 B 1-6 disorder
       Region 5fy8 B 7-353 order
       Region 5fy8 B 354-359 disorder
 Evidence X-RAY 5fy8 A Reference
       Region 5fy8 A 1-3 disorder
       Region 5fy8 A 4-353 order
       Region 5fy8 A 354-359 disorder
 Evidence X-RAY 5fpv H Reference
       Region 5fpv H 1-7 disorder
       Region 5fpv H 8-161 order
       Region 5fpv H 162-169 disorder
       Region 5fpv H 170-355 order
       Region 5fpv H 356-359 disorder
 Evidence X-RAY 5fpv G Reference
       Region 5fpv G 1-7 disorder
       Region 5fpv G 8-163 order
       Region 5fpv G 164-168 disorder
       Region 5fpv G 169-355 order
       Region 5fpv G 356-359 disorder
 Evidence X-RAY 5fpv F Reference
       Region 5fpv F 1-7 disorder
       Region 5fpv F 8-162 order
       Region 5fpv F 163-168 disorder
       Region 5fpv F 169-355 order
       Region 5fpv F 356-359 disorder
 Evidence X-RAY 5fpv E Reference
       Region 5fpv E 1-7 disorder
       Region 5fpv E 8-161 order
       Region 5fpv E 162-168 disorder
       Region 5fpv E 169-355 order
       Region 5fpv E 356-359 disorder
 Evidence X-RAY 5fpv D Reference
       Region 5fpv D 1-7 disorder
       Region 5fpv D 8-162 order
       Region 5fpv D 163-168 disorder
       Region 5fpv D 169-355 order
       Region 5fpv D 356-359 disorder
 Evidence X-RAY 5fpv C Reference
       Region 5fpv C 1-7 disorder
       Region 5fpv C 8-162 order
       Region 5fpv C 163-168 disorder
       Region 5fpv C 169-355 order
       Region 5fpv C 356-359 disorder
 Evidence X-RAY 5fpv B Reference
       Region 5fpv B 1-7 disorder
       Region 5fpv B 8-162 order
       Region 5fpv B 163-167 disorder
       Region 5fpv B 168-355 order
       Region 5fpv B 356-359 disorder
 Evidence X-RAY 5fpv A Reference
       Region 5fpv A 1-10 disorder
       Region 5fpv A 11-160 order
       Region 5fpv A 161-168 disorder
       Region 5fpv A 169-355 order
       Region 5fpv A 356-359 disorder
 Evidence X-RAY 5f5i B Reference
       Region 5f5i B 1-7 disorder
       Region 5f5i B 8-164 order
       Region 5f5i B 165-170 disorder
       Region 5f5i B 171-353 order
       Region 5f5i B 354-359 disorder
 Evidence X-RAY 5f5i A Reference
       Region 5f5i A 1-3 disorder
       Region 5f5i A 4-352 order
       Region 5f5i A 353-359 disorder
 Evidence X-RAY 5f3i D Reference
       Region 5f3i D 1-10 disorder
       Region 5f3i D 11-163 order
       Region 5f3i D 164-169 disorder
       Region 5f3i D 170-309 order
       Region 5f3i D 310-311 disorder
       Region 5f3i D 312-354 order
       Region 5f3i D 355-359 disorder
 Evidence X-RAY 5f3i C Reference
       Region 5f3i C 1-10 disorder
       Region 5f3i C 11-309 order
       Region 5f3i C 310-311 disorder
       Region 5f3i C 312-354 order
       Region 5f3i C 355-359 disorder
 Evidence X-RAY 5f3i B Reference
       Region 5f3i B 1-7 disorder
       Region 5f3i B 8-161 order
       Region 5f3i B 162-170 disorder
       Region 5f3i B 171-309 order
       Region 5f3i B 310-311 disorder
       Region 5f3i B 312-354 order
       Region 5f3i B 355-359 disorder
 Evidence X-RAY 5f3i A Reference
       Region 5f3i A 1-5 disorder
       Region 5f3i A 6-162 order
       Region 5f3i A 163-169 disorder
       Region 5f3i A 170-310 order
       Region 5f3i A 311-311 disorder
       Region 5f3i A 312-355 order
       Region 5f3i A 356-359 disorder
 Evidence X-RAY 5f3g D Reference
       Region 5f3g D 1-10 disorder
       Region 5f3g D 11-168 order
       Region 5f3g D 169-170 disorder
       Region 5f3g D 171-308 order
       Region 5f3g D 309-311 disorder
       Region 5f3g D 312-354 order
       Region 5f3g D 355-359 disorder
 Evidence X-RAY 5f3g C Reference
       Region 5f3g C 1-7 disorder
       Region 5f3g C 8-161 order
       Region 5f3g C 162-169 disorder
       Region 5f3g C 170-309 order
       Region 5f3g C 310-311 disorder
       Region 5f3g C 312-354 order
       Region 5f3g C 355-359 disorder
 Evidence X-RAY 5f3g B Reference
       Region 5f3g B 1-8 disorder
       Region 5f3g B 9-161 order
       Region 5f3g B 162-169 disorder
       Region 5f3g B 170-309 order
       Region 5f3g B 310-311 disorder
       Region 5f3g B 312-353 order
       Region 5f3g B 354-359 disorder
 Evidence X-RAY 5f3g A Reference
       Region 5f3g A 1-7 disorder
       Region 5f3g A 8-164 order
       Region 5f3g A 165-169 disorder
       Region 5f3g A 170-308 order
       Region 5f3g A 309-311 disorder
       Region 5f3g A 312-354 order
       Region 5f3g A 355-359 disorder
 Evidence X-RAY 5f3e D Reference
       Region 5f3e D 1-9 disorder
       Region 5f3e D 10-161 order
       Region 5f3e D 162-169 disorder
       Region 5f3e D 170-309 order
       Region 5f3e D 310-311 disorder
       Region 5f3e D 312-354 order
       Region 5f3e D 355-359 disorder
 Evidence X-RAY 5f3e C Reference
       Region 5f3e C 1-9 disorder
       Region 5f3e C 10-168 order
       Region 5f3e C 169-170 disorder
       Region 5f3e C 171-308 order
       Region 5f3e C 309-311 disorder
       Region 5f3e C 312-354 order
       Region 5f3e C 355-359 disorder
 Evidence X-RAY 5f3e B Reference
       Region 5f3e B 1-6 disorder
       Region 5f3e B 7-160 order
       Region 5f3e B 161-170 disorder
       Region 5f3e B 171-309 order
       Region 5f3e B 310-311 disorder
       Region 5f3e B 312-353 order
       Region 5f3e B 354-359 disorder
 Evidence X-RAY 5f3e A Reference
       Region 5f3e A 1-5 disorder
       Region 5f3e A 6-160 order
       Region 5f3e A 161-170 disorder
       Region 5f3e A 171-309 order
       Region 5f3e A 310-311 disorder
       Region 5f3e A 312-354 order
       Region 5f3e A 355-359 disorder
 Evidence X-RAY 5f3c D Reference
       Region 5f3c D 1-4 disorder
       Region 5f3c D 5-161 order
       Region 5f3c D 162-169 disorder
       Region 5f3c D 170-353 order
       Region 5f3c D 354-359 disorder
 Evidence X-RAY 5f3c C Reference
       Region 5f3c C 1-5 disorder
       Region 5f3c C 6-161 order
       Region 5f3c C 162-170 disorder
       Region 5f3c C 171-354 order
       Region 5f3c C 355-359 disorder
 Evidence X-RAY 5f3c B Reference
       Region 5f3c B 1-9 disorder
       Region 5f3c B 10-161 order
       Region 5f3c B 162-169 disorder
       Region 5f3c B 170-354 order
       Region 5f3c B 355-359 disorder
 Evidence X-RAY 5f3c A Reference
       Region 5f3c A 1-9 disorder
       Region 5f3c A 10-309 order
       Region 5f3c A 310-311 disorder
       Region 5f3c A 312-354 order
       Region 5f3c A 355-359 disorder
 Evidence X-RAY 5f39 D Reference
       Region 5f39 D 1-5 disorder
       Region 5f39 D 6-164 order
       Region 5f39 D 165-169 disorder
       Region 5f39 D 170-354 order
       Region 5f39 D 355-359 disorder
 Evidence X-RAY 5f39 C Reference
       Region 5f39 C 1-6 disorder
       Region 5f39 C 7-354 order
       Region 5f39 C 355-359 disorder
 Evidence X-RAY 5f39 B Reference
       Region 5f39 B 1-10 disorder
       Region 5f39 B 11-354 order
       Region 5f39 B 355-359 disorder
 Evidence X-RAY 5f39 A Reference
       Region 5f39 A 1-8 disorder
       Region 5f39 A 9-308 order
       Region 5f39 A 309-311 disorder
       Region 5f39 A 312-354 order
       Region 5f39 A 355-359 disorder
 Evidence X-RAY 5f37 D Reference
       Region 5f37 D 1-4 disorder
       Region 5f37 D 5-354 order
       Region 5f37 D 355-359 disorder
 Evidence X-RAY 5f37 C Reference
       Region 5f37 C 1-5 disorder
       Region 5f37 C 6-354 order
       Region 5f37 C 355-359 disorder
 Evidence X-RAY 5f37 B Reference
       Region 5f37 B 1-354 order
       Region 5f37 B 355-359 disorder
 Evidence X-RAY 5f37 A Reference
       Region 5f37 A 1-4 disorder
       Region 5f37 A 5-354 order
       Region 5f37 A 355-359 disorder
 Evidence X-RAY 5f32 D Reference
       Region 5f32 D 1-5 disorder
       Region 5f32 D 6-353 order
       Region 5f32 D 354-359 disorder
 Evidence X-RAY 5f32 C Reference
       Region 5f32 C 1-5 disorder
       Region 5f32 C 6-355 order
       Region 5f32 C 356-359 disorder
 Evidence X-RAY 5f32 B Reference
       Region 5f32 B 1-10 disorder
       Region 5f32 B 11-354 order
       Region 5f32 B 355-359 disorder
 Evidence X-RAY 5f32 A Reference
       Region 5f32 A 1-10 disorder
       Region 5f32 A 11-309 order
       Region 5f32 A 310-311 disorder
       Region 5f32 A 312-354 order
       Region 5f32 A 355-359 disorder
 Evidence X-RAY 5f2w D Reference
       Region 5f2w D 1-4 disorder
       Region 5f2w D 5-354 order
       Region 5f2w D 355-359 disorder
 Evidence X-RAY 5f2w C Reference
       Region 5f2w C 1-5 disorder
       Region 5f2w C 6-355 order
       Region 5f2w C 356-359 disorder
 Evidence X-RAY 5f2w B Reference
       Region 5f2w B 1-2 disorder
       Region 5f2w B 3-309 order
       Region 5f2w B 310-311 disorder
       Region 5f2w B 312-354 order
       Region 5f2w B 355-359 disorder
 Evidence X-RAY 5f2w A Reference
       Region 5f2w A 1-8 disorder
       Region 5f2w A 9-307 order
       Region 5f2w A 308-312 disorder
       Region 5f2w A 313-354 order
       Region 5f2w A 355-359 disorder
 Evidence X-RAY 5f2s D Reference
       Region 5f2s D 1-5 disorder
       Region 5f2s D 6-354 order
       Region 5f2s D 355-359 disorder
 Evidence X-RAY 5f2s C Reference
       Region 5f2s C 1-6 disorder
       Region 5f2s C 7-353 order
       Region 5f2s C 354-359 disorder
 Evidence X-RAY 5f2s B Reference
       Region 5f2s B 1-309 order
       Region 5f2s B 310-311 disorder
       Region 5f2s B 312-354 order
       Region 5f2s B 355-359 disorder
 Evidence X-RAY 5f2s A Reference
       Region 5f2s A 1-8 disorder
       Region 5f2s A 9-308 order
       Region 5f2s A 309-312 disorder
       Region 5f2s A 313-354 order
       Region 5f2s A 355-359 disorder
 Evidence X-RAY 4bis B Reference
       Region 4bis B 1-7 disorder
       Region 4bis B 8-355 order
       Region 4bis B 356-359 disorder
 Evidence X-RAY 4bis A Reference
       Region 4bis A 1-7 disorder
       Region 4bis A 8-355 order
       Region 4bis A 356-359 disorder
 Evidence X-RAY 5anq A Reference
       Region 5anq A 1-2 disorder
       Region 5anq A 3-352 order
       Region 5anq A 353-359 disorder
 Evidence X-RAY 5anq B Reference
       Region 5anq B 1-9 disorder
       Region 5anq B 10-353 order
       Region 5anq B 354-359 disorder
 Evidence X-RAY 4ai9 B Reference
       Region 4ai9 B 1-6 disorder
       Region 4ai9 B 7-355 order
       Region 4ai9 B 356-359 disorder
 Evidence X-RAY 4ai9 A Reference
       Region 4ai9 A 1-7 disorder
       Region 4ai9 A 8-355 order
       Region 4ai9 A 356-359 disorder
 Evidence X-RAY 5a80 B Reference
       Region 5a80 B 1-8 disorder
       Region 5a80 B 9-353 order
       Region 5a80 B 354-359 disorder
 Evidence X-RAY 5a80 A Reference
       Region 5a80 A 1-3 disorder
       Region 5a80 A 4-354 order
       Region 5a80 A 355-359 disorder
 Evidence X-RAY 5a7w B Reference
       Region 5a7w B 1-7 disorder
       Region 5a7w B 8-353 order
       Region 5a7w B 354-359 disorder
 Evidence X-RAY 5a7w A Reference
       Region 5a7w A 1-8 disorder
       Region 5a7w A 9-353 order
       Region 5a7w A 354-359 disorder
 Evidence X-RAY 5a7s B Reference
       Region 5a7s B 1-3 disorder
       Region 5a7s B 4-354 order
       Region 5a7s B 355-359 disorder
 Evidence X-RAY 5a7s A Reference
       Region 5a7s A 1-9 disorder
       Region 5a7s A 10-354 order
       Region 5a7s A 355-359 disorder
 Evidence X-RAY 5a7q B Reference
       Region 5a7q B 1-8 disorder
       Region 5a7q B 9-354 order
       Region 5a7q B 355-359 disorder
 Evidence X-RAY 5a7q A Reference
       Region 5a7q A 1-2 disorder
       Region 5a7q A 3-353 order
       Region 5a7q A 354-359 disorder
 Evidence X-RAY 5a7p B Reference
       Region 5a7p B 1-7 disorder
       Region 5a7p B 8-353 order
       Region 5a7p B 354-359 disorder
 Evidence X-RAY 5a7p A Reference
       Region 5a7p A 1-3 disorder
       Region 5a7p A 4-353 order
       Region 5a7p A 354-359 disorder
 Evidence X-RAY 5a7o B Reference
       Region 5a7o B 1-7 disorder
       Region 5a7o B 8-354 order
       Region 5a7o B 355-359 disorder
 Evidence X-RAY 5a7o A Reference
       Region 5a7o A 1-3 disorder
       Region 5a7o A 4-354 order
       Region 5a7o A 355-359 disorder
 Evidence X-RAY 5a7n B Reference
       Region 5a7n B 1-7 disorder
       Region 5a7n B 8-353 order
       Region 5a7n B 354-359 disorder
 Evidence X-RAY 5a7n A Reference
       Region 5a7n A 1-3 disorder
       Region 5a7n A 4-354 order
       Region 5a7n A 355-359 disorder
Seq 1-359 Hetero dimer : IID00086Complex
 Evidence X-RAY 2ybs B Reference
       Region 2ybs B 1-6 disorder
       Region 2ybs B 7-355 order
       Region 2ybs B 356-359 disorder
 Evidence X-RAY 2ybs A Reference
       Region 2ybs A 1-7 disorder
       Region 2ybs A 8-355 order
       Region 2ybs A 356-359 disorder
 Evidence X-RAY 2ybp B Reference
       Region 2ybp B 1-2 disorder
       Region 2ybp B 3-355 order
       Region 2ybp B 356-359 disorder
 Evidence X-RAY 2ybp A Reference
       Region 2ybp A 1-6 disorder
       Region 2ybp A 7-355 order
       Region 2ybp A 356-359 disorder
Seq 1-359 Hetero dimer : IID00086Complex
 Evidence X-RAY 4v2v A Reference
       Region 4v2v A 1-2 disorder
       Region 4v2v A 3-355 order
       Region 4v2v A 356-359 disorder
 Evidence X-RAY 4v2v B Reference
       Region 4v2v B 1-6 disorder
       Region 4v2v B 7-354 order
       Region 4v2v B 355-359 disorder
Seq 1-359 Hetero dimer :
 Evidence X-RAY 2os2 B Reference
       Region 2os2 B 1-6 disorder
       Region 2os2 B 7-354 order
       Region 2os2 B 355-359 disorder
Seq 1-359 Hetero dimer : IID00062Complex
 Evidence X-RAY 3u4s B Reference
       Region 3u4s B 1-5 disorder
       Region 3u4s B 6-354 order
       Region 3u4s B 355-359 disorder
 Evidence X-RAY 3u4s A Reference
       Region 3u4s A 1-7 disorder
       Region 3u4s A 8-352 order
       Region 3u4s A 353-359 disorder
 Evidence X-RAY 2ox0 B Reference
       Region 2ox0 B 1-6 disorder
       Region 2ox0 B 7-354 order
       Region 2ox0 B 355-359 disorder
 Evidence X-RAY 2ox0 A Reference
       Region 2ox0 A 1-6 disorder
       Region 2ox0 A 7-355 order
       Region 2ox0 A 356-359 disorder
 Evidence X-RAY 2ot7 B Reference
       Region 2ot7 B 1-6 disorder
       Region 2ot7 B 7-354 order
       Region 2ot7 B 355-359 disorder
 Evidence X-RAY 2ot7 A Reference
       Region 2ot7 A 1-6 disorder
       Region 2ot7 A 7-355 order
       Region 2ot7 A 356-359 disorder
 Evidence X-RAY 2oq6 B Reference
       Region 2oq6 B 1-6 disorder
       Region 2oq6 B 7-354 order
       Region 2oq6 B 355-359 disorder
 Evidence X-RAY 2oq6 A Reference
       Region 2oq6 A 1-7 disorder
       Region 2oq6 A 8-355 order
       Region 2oq6 A 356-359 disorder
Seq 2-348 Hetero dimer :
 Evidence X-RAY 2pxj B Reference
       Region 2pxj B 2-9 disorder
       Region 2pxj B 10-346 order
       Region 2pxj B 347-348 disorder
Seq 2-348 Hetero dimer :
 Evidence X-RAY 2pxj A Reference
       Region 2pxj A 2-348 order
Seq 2-350 Hetero dimer : P84239
 Evidence X-RAY 2p5b B Reference
       Region 2p5b B 2-9 disorder
       Region 2p5b B 10-346 order
       Region 2p5b B 347-350 disorder
 Evidence X-RAY 2p5b A Reference
       Region 2p5b A 2-348 order
       Region 2p5b A 349-350 disorder
Seq 895-1011 Hetero dimer :
 Evidence X-RAY 2gfa A Reference
       Region 2gfa A 895-947 order
       Region 2gfa A 948-954 disorder
       Region 2gfa A 955-1008 order
       Region 2gfa A 1009-1011 disorder
Seq 895-1011 Hetero dimer :
 Evidence X-RAY 2gfa B Reference
       Region 2gfa B 895-895 disorder
       Region 2gfa B 896-948 order
       Region 2gfa B 949-954 disorder
       Region 2gfa B 955-1011 order
Seq 895-1011 Monomer :
 Evidence X-RAY 2qqr B Reference
       Region 2qqr B 897-1011 order
 Evidence X-RAY 2qqr A Reference
       Region 2qqr A 897-1011 order
 Evidence X-RAY 2gf7 D Reference
       Region 2gf7 D 895-896 disorder
       Region 2gf7 D 897-1011 order
 Evidence X-RAY 2gf7 C Reference
       Region 2gf7 C 895-896 disorder
       Region 2gf7 C 897-1011 order
 Evidence X-RAY 2gf7 B Reference
       Region 2gf7 B 895-896 disorder
       Region 2gf7 B 897-1011 order
 Evidence X-RAY 2gf7 A Reference
       Region 2gf7 A 895-896 disorder
       Region 2gf7 A 897-1011 order
 Evidence X-RAY 5d6x B Reference
       Region 5d6x B 895-896 disorder
       Region 5d6x B 897-1011 order
 Evidence X-RAY 5d6x A Reference
       Region 5d6x A 895-896 disorder
       Region 5d6x A 897-1011 order
 Evidence X-RAY 5d6w D Reference
       Region 5d6w D 895-896 disorder
       Region 5d6w D 897-1011 order
 Evidence X-RAY 5d6w C Reference
       Region 5d6w C 895-896 disorder
       Region 5d6w C 897-1011 order
 Evidence X-RAY 5d6w B Reference
       Region 5d6w B 895-896 disorder
       Region 5d6w B 897-1011 order
 Evidence X-RAY 5d6w A Reference
       Region 5d6w A 895-896 disorder
       Region 5d6w A 897-1011 order
Seq 895-1011 Hetero decamer : IID00062Complex
 Evidence X-RAY 5d6y F Reference
       Region 5d6y F 895-897 disorder
       Region 5d6y F 898-1005 order
       Region 5d6y F 1006-1011 disorder
 Evidence X-RAY 5d6y E Reference
       Region 5d6y E 895-897 disorder
       Region 5d6y E 898-965 order
       Region 5d6y E 966-966 disorder
       Region 5d6y E 967-1005 order
       Region 5d6y E 1006-1011 disorder
 Evidence X-RAY 5d6y D Reference
       Region 5d6y D 895-897 disorder
       Region 5d6y D 898-990 order
       Region 5d6y D 991-992 disorder
       Region 5d6y D 993-1003 order
       Region 5d6y D 1004-1011 disorder
 Evidence X-RAY 5d6y C Reference
       Region 5d6y C 895-897 disorder
       Region 5d6y C 898-990 order
       Region 5d6y C 991-992 disorder
       Region 5d6y C 993-1003 order
       Region 5d6y C 1004-1011 disorder
 Evidence X-RAY 5d6y B Reference
       Region 5d6y B 895-897 disorder
       Region 5d6y B 898-1005 order
       Region 5d6y B 1006-1011 disorder
 Evidence X-RAY 5d6y A Reference
       Region 5d6y A 895-897 disorder
       Region 5d6y A 898-1005 order
       Region 5d6y A 1006-1011 disorder
Seq 897-1011 Hetero dimer : IID00058Complex
 Evidence X-RAY 2qqs B Reference
       Region 2qqs B 897-898 disorder
       Region 2qqs B 899-1006 order
       Region 2qqs B 1007-1011 disorder
 Evidence X-RAY 2qqs A Reference
       Region 2qqs A 897-1005 order
       Region 2qqs A 1006-1011 disorder
Seqphosphorylation
    523-523 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-9,341-461,490-635,683-699,707-752,1022-1045
Order 10-340,462-489,636-682,700-706,753-1021,1046-1064
ProS 341-357,367-384,394-405,422-431,532-539,553-559,574-585,607-615,707-752,1022-1035,1045-1045
AlphaFold
Disorder 1-6,164-164,168-170,355-633,681-699,713-725,838-840,872-875,885-897,1020-1064
Order 7-163,165-167,171-354,634-680,700-712,726-837,841-871,876-884,898-1019
Pfam Hmmer
PF02375 15-60 3.7e-27
PF02373 175-291 2.9e-63
SEG 371-384 ,461-488 ,502-532 ,619-637 ,1032-1044
Function
Function in SwissProt
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
Isoform 2
Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.