Search Keyword:


Search option:


IID00361
 UniprotO75469
ProteinNuclear receptor subfamily 1 group I member 2
GeneNR1I2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
434
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 130-434 Hetero tetramer : IID00031Complex,IID00083Complex
 Evidence X-RAY 4j5x B Reference
       Region 4j5x B 130-138 disorder
       Region 4j5x B 139-177 order
       Region 4j5x B 178-191 disorder
       Region 4j5x B 192-312 order
       Region 4j5x B 313-316 disorder
       Region 4j5x B 317-431 order
       Region 4j5x B 432-434 disorder
 Evidence X-RAY 4j5x A Reference
       Region 4j5x A 130-140 disorder
       Region 4j5x A 141-177 order
       Region 4j5x A 178-191 disorder
       Region 4j5x A 192-432 order
       Region 4j5x A 433-434 disorder
Seq 130-434 Homo dimer :
 Evidence X-RAY 4xao A Reference
       Region 4xao A 130-141 disorder
       Region 4xao A 142-177 order
       Region 4xao A 178-191 disorder
       Region 4xao A 192-310 order
       Region 4xao A 311-314 disorder
       Region 4xao A 315-434 order
 Evidence X-RAY 4x1g A Reference
       Region 4x1g A 130-141 disorder
       Region 4x1g A 142-177 order
       Region 4x1g A 178-191 disorder
       Region 4x1g A 192-434 order
 Evidence X-RAY 4x1f A Reference
       Region 4x1f A 130-141 disorder
       Region 4x1f A 142-177 order
       Region 4x1f A 178-194 disorder
       Region 4x1f A 195-310 order
       Region 4x1f A 311-315 disorder
       Region 4x1f A 316-434 order
 Evidence X-RAY 2qnv A Reference
       Region 2qnv A 130-141 disorder
       Region 2qnv A 142-177 order
       Region 2qnv A 178-208 disorder
       Region 2qnv A 209-229 order
       Region 2qnv A 230-236 disorder
       Region 2qnv A 237-309 order
       Region 2qnv A 310-315 disorder
       Region 2qnv A 316-434 order
Seq 130-434 Monomer : IID00083Complex
 Evidence X-RAY 3ctb B Reference
       Region 3ctb B 130-141 disorder
       Region 3ctb B 142-178 order
       Region 3ctb B 179-191 disorder
       Region 3ctb B 192-309 order
       Region 3ctb B 310-316 disorder
       Region 3ctb B 317-431 order
       Region 3ctb B 432-434 disorder
Seq 130-434 Hetero tetramer : IID00031Complex
 Evidence X-RAY 4j5w B Reference
       Region 4j5w B 130-140 disorder
       Region 4j5w B 141-177 order
       Region 4j5w B 178-192 disorder
       Region 4j5w B 193-311 order
       Region 4j5w B 312-314 disorder
       Region 4j5w B 315-432 order
       Region 4j5w B 433-434 disorder
 Evidence X-RAY 4j5w A Reference
       Region 4j5w A 130-140 disorder
       Region 4j5w A 141-177 order
       Region 4j5w A 178-192 disorder
       Region 4j5w A 193-312 order
       Region 4j5w A 313-314 disorder
       Region 4j5w A 315-432 order
       Region 4j5w A 433-434 disorder
Seq 130-434 Hetero dimer :
 Evidence X-RAY 4s0s B Reference
       Region 4s0s B 130-142 disorder
       Region 4s0s B 143-177 order
       Region 4s0s B 178-191 disorder
       Region 4s0s B 192-429 order
       Region 4s0s B 430-434 disorder
Seq 130-434 Monomer : IID00083Complex
 Evidence X-RAY 3hvl A Reference
       Region 3hvl A 130-141 disorder
       Region 3hvl A 142-178 order
       Region 3hvl A 179-191 disorder
       Region 3hvl A 192-309 order
       Region 3hvl A 310-315 disorder
       Region 3hvl A 316-432 order
       Region 3hvl A 433-434 disorder
Seq 130-434 Hetero dimer : IID00083Complex
 Evidence X-RAY 1nrl B Reference
       Region 1nrl B 130-141 disorder
       Region 1nrl B 142-177 order
       Region 1nrl B 178-192 disorder
       Region 1nrl B 193-431 order
       Region 1nrl B 432-434 disorder
 Evidence X-RAY 1nrl A Reference
       Region 1nrl A 130-141 disorder
       Region 1nrl A 142-177 order
       Region 1nrl A 178-191 disorder
       Region 1nrl A 192-433 order
       Region 1nrl A 434-434 disorder
Seq 130-434 Monomer : IID00083Complex
 Evidence X-RAY 3hvl B Reference
       Region 3hvl B 130-139 disorder
       Region 3hvl B 140-178 order
       Region 3hvl B 179-191 disorder
       Region 3hvl B 192-309 order
       Region 3hvl B 310-316 disorder
       Region 3hvl B 317-431 order
       Region 3hvl B 432-434 disorder
Seq 130-434 Hetero tetramer :
 Evidence X-RAY 4s0t A Reference
       Region 4s0t A 130-142 disorder
       Region 4s0t A 143-177 order
       Region 4s0t A 178-185 disorder
       Region 4s0t A 186-429 order
       Region 4s0t A 430-434 disorder
 Evidence X-RAY 4s0t B Reference
       Region 4s0t B 130-141 disorder
       Region 4s0t B 142-178 order
       Region 4s0t B 179-185 disorder
       Region 4s0t B 186-431 order
       Region 4s0t B 432-434 disorder
Seq 130-434 Monomer :
 Evidence X-RAY 4xhd A Reference
       Region 4xhd A 130-141 disorder
       Region 4xhd A 142-178 order
       Region 4xhd A 179-196 disorder
       Region 4xhd A 197-309 order
       Region 4xhd A 310-313 disorder
       Region 4xhd A 314-431 order
       Region 4xhd A 432-434 disorder
 Evidence X-RAY 1skx A Reference
       Region 1skx A 130-142 disorder
       Region 1skx A 143-177 order
       Region 1skx A 178-209 disorder
       Region 1skx A 210-228 order
       Region 1skx A 229-235 disorder
       Region 1skx A 236-309 order
       Region 1skx A 310-317 disorder
       Region 1skx A 318-431 order
 Evidence X-RAY 3r8d A Reference
       Region 3r8d A 130-141 disorder
       Region 3r8d A 142-176 order
       Region 3r8d A 177-197 disorder
       Region 3r8d A 198-309 order
       Region 3r8d A 310-314 disorder
       Region 3r8d A 315-431 order
       Region 3r8d A 432-434 disorder
 Evidence X-RAY 4ny9 A Reference
       Region 4ny9 A 142-176 order
       Region 4ny9 A 177-200 disorder
       Region 4ny9 A 201-309 order
       Region 4ny9 A 310-315 disorder
       Region 4ny9 A 316-431 order
 Evidence X-RAY 1m13 A Reference
       Region 1m13 A 130-141 disorder
       Region 1m13 A 142-177 order
       Region 1m13 A 178-197 disorder
       Region 1m13 A 198-434 order
 Evidence X-RAY 1ilh A Reference
       Region 1ilh A 130-141 disorder
       Region 1ilh A 142-177 order
       Region 1ilh A 178-197 disorder
       Region 1ilh A 198-431 order
       Region 1ilh A 432-434 disorder
 Evidence X-RAY 1ilg A Reference
       Region 1ilg A 130-141 disorder
       Region 1ilg A 142-177 order
       Region 1ilg A 178-197 disorder
       Region 1ilg A 198-431 order
       Region 1ilg A 432-434 disorder
Seq 130-434 Monomer : IID00083Complex
 Evidence X-RAY 3ctb A Reference
       Region 3ctb A 130-141 disorder
       Region 3ctb A 142-178 order
       Region 3ctb A 179-191 disorder
       Region 3ctb A 192-309 order
       Region 3ctb A 310-315 disorder
       Region 3ctb A 316-432 order
       Region 3ctb A 433-434 disorder
Seq 130-434 Hetero dimer :
 Evidence X-RAY 4s0s A Reference
       Region 4s0s A 130-142 disorder
       Region 4s0s A 143-177 order
       Region 4s0s A 178-191 disorder
       Region 4s0s A 192-429 order
       Region 4s0s A 430-434 disorder
Seq 130-434 Homo dimer : IID00083Complex
 Evidence X-RAY 6bns B Reference
       Region 6bns B 130-141 disorder
       Region 6bns B 142-177 order
       Region 6bns B 178-195 disorder
       Region 6bns B 196-309 order
       Region 6bns B 310-314 disorder
       Region 6bns B 315-432 order
       Region 6bns B 433-434 disorder
 Evidence X-RAY 6bns A Reference
       Region 6bns A 130-141 disorder
       Region 6bns A 142-177 order
       Region 6bns A 178-191 disorder
       Region 6bns A 192-309 order
       Region 6bns A 310-315 disorder
       Region 6bns A 316-432 order
       Region 6bns A 433-434 disorder
Seq 130-434 Hetero tetramer : IID00083Complex
 Evidence X-RAY 5x0r B Reference
       Region 5x0r B 130-138 disorder
       Region 5x0r B 139-177 order
       Region 5x0r B 178-206 disorder
       Region 5x0r B 207-310 order
       Region 5x0r B 311-315 disorder
       Region 5x0r B 316-429 order
       Region 5x0r B 430-434 disorder
 Evidence X-RAY 5x0r A Reference
       Region 5x0r A 130-141 disorder
       Region 5x0r A 142-177 order
       Region 5x0r A 178-210 disorder
       Region 5x0r A 211-229 order
       Region 5x0r A 230-237 disorder
       Region 5x0r A 238-308 order
       Region 5x0r A 309-318 disorder
       Region 5x0r A 319-381 order
       Region 5x0r A 382-384 disorder
       Region 5x0r A 385-432 order
       Region 5x0r A 433-434 disorder
 Evidence X-RAY 5a86 B Reference
       Region 5a86 B 130-140 disorder
       Region 5a86 B 141-177 order
       Region 5a86 B 178-191 disorder
       Region 5a86 B 192-310 order
       Region 5a86 B 311-313 disorder
       Region 5a86 B 314-431 order
       Region 5a86 B 432-432 disorder
 Evidence X-RAY 5a86 A Reference
       Region 5a86 A 130-142 disorder
       Region 5a86 A 143-177 order
       Region 5a86 A 178-193 disorder
       Region 5a86 A 194-312 order
       Region 5a86 A 313-315 disorder
       Region 5a86 A 316-432 order
Seq 142-434 Hetero dimer : IID50084Complex
 Evidence X-RAY 2o9i B Reference
       Region 2o9i B 142-178 order
       Region 2o9i B 179-191 disorder
       Region 2o9i B 192-433 order
       Region 2o9i B 434-434 disorder
 Evidence X-RAY 2o9i A Reference
       Region 2o9i A 142-178 order
       Region 2o9i A 179-191 disorder
       Region 2o9i A 192-433 order
       Region 2o9i A 434-434 disorder
 
Prediction
NeProc
Disorder 1-36,121-235
Order 37-120,236-434
ProS 1-14,121-125,150-153,159-177,197-209
AlphaFold
Disorder 1-38,130-141,177-190,433-434
Order 39-129,142-176,191-432
Pfam Hmmer
PF00105 39-115 4.9e-41
PF00104 248-428 7.2e-41
Function
Function in SwissProt
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
Biological Process
See also
Diagram with PDB data
Ncoa1/ESR1Crystal structure of ERa LBD in complex with RU100132
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment