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IID00362
UniprotO95503
ProteinChromobox protein homolog 6
GeneCBX6
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
412
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 8-65 Hetero dimer : IID50147Complex
 Evidence X-RAY 3gv6 A Reference
       Region 3gv6 A 8-63 order
       Region 3gv6 A 64-65 disorder
Seq 9-59 Hetero tetramer :
 Evidence X-RAY 3i90 B Reference
       Region 3i90 B 9-9 disorder
       Region 3i90 B 10-59 order
 Evidence X-RAY 3i90 A Reference
       Region 3i90 A 9-58 order
       Region 3i90 A 59-59 disorder
Seqphosphorylation
    107-107 Phosphoserine
 
Prediction
NeProc
Disorder 1-4,63-356,396-412
Order 5-62,357-395
ProS 63-71,78-83,121-125,155-159,204-210
AlphaFold
Disorder 1-7,69-85,88-117,133-365,387-412
Order 8-68,86-87,118-132,366-386
Pfam Hmmer
PF00385 11-60 2.5e-19
SEG 16-26 ,98-115 ,184-198 ,237-247 ,254-267 ,272-293 ,328-355 ,394-411
Function
Function in SwissProt
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity).