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IID00369
 UniprotP35269
ProteinGeneral transcription factor IIF subunit 1
GeneGTF2F1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
517
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-172 Hetero dimer : P13984
 Evidence X-RAY 1f3u H Reference
       Region 1f3u H 2-6 disorder
       Region 1f3u H 7-62 order
       Region 1f3u H 63-72 disorder
       Region 1f3u H 73-153 order
       Region 1f3u H 154-172 disorder
 Evidence X-RAY 1f3u F Reference
       Region 1f3u F 2-4 disorder
       Region 1f3u F 5-62 order
       Region 1f3u F 63-72 disorder
       Region 1f3u F 73-168 order
       Region 1f3u F 169-172 disorder
 Evidence X-RAY 1f3u D Reference
       Region 1f3u D 2-6 disorder
       Region 1f3u D 7-63 order
       Region 1f3u D 64-72 disorder
       Region 1f3u D 73-168 order
       Region 1f3u D 169-172 disorder
 Evidence X-RAY 1f3u B Reference
       Region 1f3u B 2-4 disorder
       Region 1f3u B 5-62 order
       Region 1f3u B 63-72 disorder
       Region 1f3u B 73-153 order
       Region 1f3u B 154-172 disorder
Seq 436-517 Monomer :
 Evidence NMR 1nha A Reference
       Region 1nha A 436-450 disorder
       Region 1nha A 451-517 order
       Region 1nha A 451-451 high_rmsd
 Evidence X-RAY 1i27 A Reference
       Region 1i27 A 449-517 order
Seq 436-517 Hetero dimer : IID00117Complex
 Evidence NMR 1onv A Reference
       Region 1onv A 436-450 disorder
       Region 1onv A 451-517 order
 Evidence X-RAY 1j2x A Reference
       Region 1j2x A 449-450 disorder
       Region 1j2x A 451-517 order
Seq 451-517 Hetero dimer : IID00117Complex
 Evidence NMR 2k7l A Reference
       Region 2k7l A 451-517 order
Seqphosphorylation
    217-217 Phosphoserine
    156-156 Phosphothreonine
    221-221 Phosphoserine
    218-218 Phosphoserine
    436-436 Phosphoserine
    446-446 Phosphothreonine
    449-449 Phosphoserine
    437-437 Phosphothreonine
    433-433 Phosphoserine
    331-331 Phosphothreonine
    431-431 Phosphoserine
    389-389 Phosphothreonine
    391-391 Phosphoserine
    385-385 Phosphoserine
    380-380 Phosphoserine
    381-381 Phosphoserine
    377-377 Phosphoserine
    224-224 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    407-407 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-9,49-90,182-455
Order 10-48,91-181,456-481,485-517
ProS 49-90,182-187,203-216,228-279,295-301,451-455
AlphaFold
Disorder 1-4,55-81,83-89,118-118,151-171,184-453,479-483,517-517
Order 5-54,82-82,90-117,119-150,172-183,454-478,484-516
SEG 157-165 ,178-201 ,233-268 ,303-336 ,340-359 ,365-391
Function
Function in SwissProt
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.