Search Keyword:


Search option:


IID00371
 UniprotP40337
Proteinvon Hippel-Lindau disease tumor suppressor
GeneVHL
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
213
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-213 Hetero tetramer : Q13617,Q15369,Q15370
 Evidence X-RAY 4wqo A Reference
       Region 4wqo A 1-59 disorder
       Region 4wqo A 60-207 order
       Region 4wqo A 208-213 disorder
Seq 54-213 Hetero trimer : Q15369,Q15370
 Evidence X-RAY 3zun L Reference
       Region 3zun L 54-61 disorder
       Region 3zun L 62-141 order
       Region 3zun L 142-144 disorder
       Region 3zun L 145-203 order
       Region 3zun L 204-213 disorder
 Evidence X-RAY 3zun I Reference
       Region 3zun I 54-61 disorder
       Region 3zun I 62-205 order
       Region 3zun I 206-213 disorder
 Evidence X-RAY 3zun F Reference
       Region 3zun F 54-62 disorder
       Region 3zun F 63-205 order
       Region 3zun F 206-213 disorder
 Evidence X-RAY 3zun C Reference
       Region 3zun C 54-61 disorder
       Region 3zun C 62-140 order
       Region 3zun C 141-146 disorder
       Region 3zun C 147-204 order
       Region 3zun C 205-213 disorder
 Evidence X-RAY 3ztd L Reference
       Region 3ztd L 54-62 disorder
       Region 3ztd L 63-204 order
       Region 3ztd L 205-213 disorder
 Evidence X-RAY 3ztd I Reference
       Region 3ztd I 54-62 disorder
       Region 3ztd I 63-204 order
       Region 3ztd I 205-213 disorder
 Evidence X-RAY 3ztd F Reference
       Region 3ztd F 54-62 disorder
       Region 3ztd F 63-204 order
       Region 3ztd F 205-213 disorder
 Evidence X-RAY 3ztd C Reference
       Region 3ztd C 54-62 disorder
       Region 3ztd C 63-139 order
       Region 3ztd C 140-142 disorder
       Region 3ztd C 143-204 order
       Region 3ztd C 205-213 disorder
 Evidence X-RAY 3ztc L Reference
       Region 3ztc L 54-61 disorder
       Region 3ztc L 62-204 order
       Region 3ztc L 205-213 disorder
 Evidence X-RAY 3ztc I Reference
       Region 3ztc I 54-61 disorder
       Region 3ztc I 62-206 order
       Region 3ztc I 207-213 disorder
 Evidence X-RAY 3ztc F Reference
       Region 3ztc F 54-62 disorder
       Region 3ztc F 63-204 order
       Region 3ztc F 205-213 disorder
 Evidence X-RAY 3ztc C Reference
       Region 3ztc C 54-62 disorder
       Region 3ztc C 63-141 order
       Region 3ztc C 142-142 disorder
       Region 3ztc C 143-204 order
       Region 3ztc C 205-213 disorder
 Evidence X-RAY 3zrf L Reference
       Region 3zrf L 54-61 disorder
       Region 3zrf L 62-204 order
       Region 3zrf L 205-213 disorder
 Evidence X-RAY 3zrf I Reference
       Region 3zrf I 54-61 disorder
       Region 3zrf I 62-206 order
       Region 3zrf I 207-213 disorder
 Evidence X-RAY 3zrf F Reference
       Region 3zrf F 54-62 disorder
       Region 3zrf F 63-204 order
       Region 3zrf F 205-213 disorder
 Evidence X-RAY 3zrf C Reference
       Region 3zrf C 54-62 disorder
       Region 3zrf C 63-204 order
       Region 3zrf C 205-213 disorder
 Evidence X-RAY 3zrc L Reference
       Region 3zrc L 54-61 disorder
       Region 3zrc L 62-204 order
       Region 3zrc L 205-213 disorder
 Evidence X-RAY 3zrc I Reference
       Region 3zrc I 54-61 disorder
       Region 3zrc I 62-206 order
       Region 3zrc I 207-213 disorder
 Evidence X-RAY 3zrc F Reference
       Region 3zrc F 54-62 disorder
       Region 3zrc F 63-204 order
       Region 3zrc F 205-213 disorder
 Evidence X-RAY 4w9l L Reference
       Region 4w9l L 54-61 disorder
       Region 4w9l L 62-204 order
       Region 4w9l L 205-213 disorder
 Evidence X-RAY 4w9l I Reference
       Region 4w9l I 54-61 disorder
       Region 4w9l I 62-204 order
       Region 4w9l I 205-213 disorder
 Evidence X-RAY 4w9l F Reference
       Region 4w9l F 54-61 disorder
       Region 4w9l F 62-205 order
       Region 4w9l F 206-213 disorder
 Evidence X-RAY 4w9l C Reference
       Region 4w9l C 54-61 disorder
       Region 4w9l C 62-202 order
       Region 4w9l C 203-213 disorder
 Evidence X-RAY 4w9k L Reference
       Region 4w9k L 54-61 disorder
       Region 4w9k L 62-204 order
       Region 4w9k L 205-213 disorder
 Evidence X-RAY 4w9k I Reference
       Region 4w9k I 54-61 disorder
       Region 4w9k I 62-181 order
       Region 4w9k I 182-182 disorder
       Region 4w9k I 183-204 order
       Region 4w9k I 205-213 disorder
 Evidence X-RAY 4w9k F Reference
       Region 4w9k F 54-61 disorder
       Region 4w9k F 62-205 order
       Region 4w9k F 206-213 disorder
 Evidence X-RAY 4w9k C Reference
       Region 4w9k C 54-61 disorder
       Region 4w9k C 62-202 order
       Region 4w9k C 203-213 disorder
 Evidence X-RAY 4w9j L Reference
       Region 4w9j L 54-61 disorder
       Region 4w9j L 62-181 order
       Region 4w9j L 182-182 disorder
       Region 4w9j L 183-204 order
       Region 4w9j L 205-213 disorder
 Evidence X-RAY 4w9j I Reference
       Region 4w9j I 54-61 disorder
       Region 4w9j I 62-204 order
       Region 4w9j I 205-213 disorder
 Evidence X-RAY 4w9j F Reference
       Region 4w9j F 54-61 disorder
       Region 4w9j F 62-205 order
       Region 4w9j F 206-213 disorder
 Evidence X-RAY 4w9j C Reference
       Region 4w9j C 54-61 disorder
       Region 4w9j C 62-202 order
       Region 4w9j C 203-213 disorder
 Evidence X-RAY 4w9f L Reference
       Region 4w9f L 54-61 disorder
       Region 4w9f L 62-175 order
       Region 4w9f L 176-185 disorder
       Region 4w9f L 186-204 order
       Region 4w9f L 205-213 disorder
 Evidence X-RAY 4w9f I Reference
       Region 4w9f I 54-61 disorder
       Region 4w9f I 62-205 order
       Region 4w9f I 206-213 disorder
 Evidence X-RAY 4w9f F Reference
       Region 4w9f F 54-61 disorder
       Region 4w9f F 62-203 order
       Region 4w9f F 204-213 disorder
 Evidence X-RAY 4w9f C Reference
       Region 4w9f C 54-61 disorder
       Region 4w9f C 62-141 order
       Region 4w9f C 142-142 disorder
       Region 4w9f C 143-203 order
       Region 4w9f C 204-213 disorder
 Evidence X-RAY 5nw2 L Reference
       Region 5nw2 L 54-61 disorder
       Region 5nw2 L 62-204 order
       Region 5nw2 L 205-213 disorder
 Evidence X-RAY 5nw2 I Reference
       Region 5nw2 I 54-61 disorder
       Region 5nw2 I 62-204 order
       Region 5nw2 I 205-213 disorder
 Evidence X-RAY 5nw2 F Reference
       Region 5nw2 F 54-61 disorder
       Region 5nw2 F 62-204 order
       Region 5nw2 F 205-213 disorder
 Evidence X-RAY 5nw2 C Reference
       Region 5nw2 C 54-61 disorder
       Region 5nw2 C 62-202 order
       Region 5nw2 C 203-213 disorder
 Evidence X-RAY 5nw1 L Reference
       Region 5nw1 L 54-61 disorder
       Region 5nw1 L 62-204 order
       Region 5nw1 L 205-213 disorder
 Evidence X-RAY 5nw1 I Reference
       Region 5nw1 I 54-61 disorder
       Region 5nw1 I 62-204 order
       Region 5nw1 I 205-213 disorder
 Evidence X-RAY 5nw1 F Reference
       Region 5nw1 F 54-61 disorder
       Region 5nw1 F 62-204 order
       Region 5nw1 F 205-213 disorder
 Evidence X-RAY 5nw1 C Reference
       Region 5nw1 C 54-61 disorder
       Region 5nw1 C 62-202 order
       Region 5nw1 C 203-213 disorder
 Evidence X-RAY 5nw0 L Reference
       Region 5nw0 L 54-61 disorder
       Region 5nw0 L 62-204 order
       Region 5nw0 L 205-213 disorder
 Evidence X-RAY 5nw0 I Reference
       Region 5nw0 I 54-61 disorder
       Region 5nw0 I 62-204 order
       Region 5nw0 I 205-213 disorder
 Evidence X-RAY 5nw0 F Reference
       Region 5nw0 F 54-61 disorder
       Region 5nw0 F 62-204 order
       Region 5nw0 F 205-213 disorder
 Evidence X-RAY 5nw0 C Reference
       Region 5nw0 C 54-61 disorder
       Region 5nw0 C 62-202 order
       Region 5nw0 C 203-213 disorder
 Evidence X-RAY 5nvz L Reference
       Region 5nvz L 54-61 disorder
       Region 5nvz L 62-204 order
       Region 5nvz L 205-213 disorder
 Evidence X-RAY 5nvz I Reference
       Region 5nvz I 54-61 disorder
       Region 5nvz I 62-204 order
       Region 5nvz I 205-213 disorder
 Evidence X-RAY 5nvz F Reference
       Region 5nvz F 54-61 disorder
       Region 5nvz F 62-204 order
       Region 5nvz F 205-213 disorder
 Evidence X-RAY 5nvz C Reference
       Region 5nvz C 54-61 disorder
       Region 5nvz C 62-203 order
       Region 5nvz C 204-213 disorder
 Evidence X-RAY 5nvy L Reference
       Region 5nvy L 54-61 disorder
       Region 5nvy L 62-204 order
       Region 5nvy L 205-213 disorder
 Evidence X-RAY 5nvy I Reference
       Region 5nvy I 54-61 disorder
       Region 5nvy I 62-204 order
       Region 5nvy I 205-213 disorder
 Evidence X-RAY 5nvy F Reference
       Region 5nvy F 54-61 disorder
       Region 5nvy F 62-204 order
       Region 5nvy F 205-213 disorder
 Evidence X-RAY 5nvy C Reference
       Region 5nvy C 54-61 disorder
       Region 5nvy C 62-202 order
       Region 5nvy C 203-213 disorder
 Evidence X-RAY 5nvx L Reference
       Region 5nvx L 54-61 disorder
       Region 5nvx L 62-204 order
       Region 5nvx L 205-213 disorder
 Evidence X-RAY 5nvx I Reference
       Region 5nvx I 54-61 disorder
       Region 5nvx I 62-204 order
       Region 5nvx I 205-213 disorder
 Evidence X-RAY 5nvx F Reference
       Region 5nvx F 54-61 disorder
       Region 5nvx F 62-204 order
       Region 5nvx F 205-213 disorder
 Evidence X-RAY 5nvx C Reference
       Region 5nvx C 54-61 disorder
       Region 5nvx C 62-202 order
       Region 5nvx C 203-213 disorder
 Evidence X-RAY 5nvw L Reference
       Region 5nvw L 54-61 disorder
       Region 5nvw L 62-204 order
       Region 5nvw L 205-213 disorder
 Evidence X-RAY 5nvw I Reference
       Region 5nvw I 54-61 disorder
       Region 5nvw I 62-204 order
       Region 5nvw I 205-213 disorder
 Evidence X-RAY 5nvw F Reference
       Region 5nvw F 54-61 disorder
       Region 5nvw F 62-204 order
       Region 5nvw F 205-213 disorder
 Evidence X-RAY 5nvw C Reference
       Region 5nvw C 54-61 disorder
       Region 5nvw C 62-202 order
       Region 5nvw C 203-213 disorder
 Evidence X-RAY 5nvv L Reference
       Region 5nvv L 54-61 disorder
       Region 5nvv L 62-204 order
       Region 5nvv L 205-213 disorder
 Evidence X-RAY 5nvv I Reference
       Region 5nvv I 54-61 disorder
       Region 5nvv I 62-204 order
       Region 5nvv I 205-213 disorder
 Evidence X-RAY 5nvv F Reference
       Region 5nvv F 54-61 disorder
       Region 5nvv F 62-204 order
       Region 5nvv F 205-213 disorder
 Evidence X-RAY 5nvv C Reference
       Region 5nvv C 54-61 disorder
       Region 5nvv C 62-202 order
       Region 5nvv C 203-213 disorder
 Evidence X-RAY 5lli L Reference
       Region 5lli L 54-61 disorder
       Region 5lli L 62-204 order
       Region 5lli L 205-213 disorder
 Evidence X-RAY 5lli I Reference
       Region 5lli I 54-61 disorder
       Region 5lli I 62-204 order
       Region 5lli I 205-213 disorder
 Evidence X-RAY 5lli F Reference
       Region 5lli F 54-61 disorder
       Region 5lli F 62-204 order
       Region 5lli F 205-213 disorder
 Evidence X-RAY 5lli C Reference
       Region 5lli C 54-61 disorder
       Region 5lli C 62-203 order
       Region 5lli C 204-213 disorder
 Evidence X-RAY 4bkt F Reference
       Region 4bkt F 54-62 disorder
       Region 4bkt F 63-203 order
       Region 4bkt F 204-213 disorder
 Evidence X-RAY 4bkt L Reference
       Region 4bkt L 54-61 disorder
       Region 4bkt L 62-205 order
       Region 4bkt L 206-213 disorder
 Evidence X-RAY 4bkt I Reference
       Region 4bkt I 54-61 disorder
       Region 4bkt I 62-204 order
       Region 4bkt I 205-213 disorder
 Evidence X-RAY 4bkt C Reference
       Region 4bkt C 54-61 disorder
       Region 4bkt C 62-142 order
       Region 4bkt C 143-144 disorder
       Region 4bkt C 145-201 order
       Region 4bkt C 202-213 disorder
 Evidence X-RAY 4bks F Reference
       Region 4bks F 54-62 disorder
       Region 4bks F 63-204 order
       Region 4bks F 205-213 disorder
 Evidence X-RAY 4bks I Reference
       Region 4bks I 54-61 disorder
       Region 4bks I 62-205 order
       Region 4bks I 206-213 disorder
 Evidence X-RAY 4bks L Reference
       Region 4bks L 54-61 disorder
       Region 4bks L 62-205 order
       Region 4bks L 206-213 disorder
 Evidence X-RAY 4bks C Reference
       Region 4bks C 54-61 disorder
       Region 4bks C 62-141 order
       Region 4bks C 142-144 disorder
       Region 4bks C 145-202 order
       Region 4bks C 203-213 disorder
 Evidence X-RAY 4b9k L Reference
       Region 4b9k L 54-61 disorder
       Region 4b9k L 62-207 order
       Region 4b9k L 208-213 disorder
 Evidence X-RAY 4b9k I Reference
       Region 4b9k I 54-61 disorder
       Region 4b9k I 62-208 order
       Region 4b9k I 209-213 disorder
 Evidence X-RAY 4b9k F Reference
       Region 4b9k F 54-61 disorder
       Region 4b9k F 62-204 order
       Region 4b9k F 205-213 disorder
 Evidence X-RAY 4b9k C Reference
       Region 4b9k C 54-61 disorder
       Region 4b9k C 62-141 order
       Region 4b9k C 142-144 disorder
       Region 4b9k C 145-202 order
       Region 4b9k C 203-213 disorder
 Evidence X-RAY 4awj L Reference
       Region 4awj L 54-61 disorder
       Region 4awj L 62-205 order
       Region 4awj L 206-213 disorder
 Evidence X-RAY 4awj I Reference
       Region 4awj I 54-61 disorder
       Region 4awj I 62-205 order
       Region 4awj I 206-213 disorder
 Evidence X-RAY 4awj F Reference
       Region 4awj F 54-62 disorder
       Region 4awj F 63-204 order
       Region 4awj F 205-213 disorder
 Evidence X-RAY 4awj C Reference
       Region 4awj C 54-61 disorder
       Region 4awj C 62-142 order
       Region 4awj C 143-145 disorder
       Region 4awj C 146-200 order
       Region 4awj C 201-213 disorder
Seq 54-213 Hetero dodecamer : Q15369,Q15370
 Evidence X-RAY 4w9i L Reference
       Region 4w9i L 54-61 disorder
       Region 4w9i L 62-204 order
       Region 4w9i L 205-213 disorder
 Evidence X-RAY 4w9i I Reference
       Region 4w9i I 54-61 disorder
       Region 4w9i I 62-204 order
       Region 4w9i I 205-213 disorder
 Evidence X-RAY 4w9i F Reference
       Region 4w9i F 54-61 disorder
       Region 4w9i F 62-205 order
       Region 4w9i F 206-213 disorder
 Evidence X-RAY 4w9i C Reference
       Region 4w9i C 54-61 disorder
       Region 4w9i C 62-202 order
       Region 4w9i C 203-213 disorder
 Evidence X-RAY 4w9h L Reference
       Region 4w9h L 54-61 disorder
       Region 4w9h L 62-204 order
       Region 4w9h L 205-213 disorder
 Evidence X-RAY 4w9h I Reference
       Region 4w9h I 54-61 disorder
       Region 4w9h I 62-204 order
       Region 4w9h I 205-213 disorder
 Evidence X-RAY 4w9h F Reference
       Region 4w9h F 54-61 disorder
       Region 4w9h F 62-205 order
       Region 4w9h F 206-213 disorder
 Evidence X-RAY 4w9h C Reference
       Region 4w9h C 54-61 disorder
       Region 4w9h C 62-202 order
       Region 4w9h C 203-213 disorder
 Evidence X-RAY 4w9g L Reference
       Region 4w9g L 54-61 disorder
       Region 4w9g L 62-204 order
       Region 4w9g L 205-213 disorder
 Evidence X-RAY 4w9g I Reference
       Region 4w9g I 54-61 disorder
       Region 4w9g I 62-204 order
       Region 4w9g I 205-213 disorder
 Evidence X-RAY 4w9g F Reference
       Region 4w9g F 54-61 disorder
       Region 4w9g F 62-205 order
       Region 4w9g F 206-213 disorder
 Evidence X-RAY 4w9g C Reference
       Region 4w9g C 54-61 disorder
       Region 4w9g C 62-202 order
       Region 4w9g C 203-213 disorder
 Evidence X-RAY 4w9e L Reference
       Region 4w9e L 54-61 disorder
       Region 4w9e L 62-204 order
       Region 4w9e L 205-213 disorder
 Evidence X-RAY 4w9e I Reference
       Region 4w9e I 54-61 disorder
       Region 4w9e I 62-204 order
       Region 4w9e I 205-213 disorder
 Evidence X-RAY 4w9e F Reference
       Region 4w9e F 54-61 disorder
       Region 4w9e F 62-205 order
       Region 4w9e F 206-213 disorder
 Evidence X-RAY 4w9e C Reference
       Region 4w9e C 54-61 disorder
       Region 4w9e C 62-202 order
       Region 4w9e C 203-213 disorder
 Evidence X-RAY 4w9d L Reference
       Region 4w9d L 54-61 disorder
       Region 4w9d L 62-204 order
       Region 4w9d L 205-213 disorder
 Evidence X-RAY 4w9d I Reference
       Region 4w9d I 54-61 disorder
       Region 4w9d I 62-204 order
       Region 4w9d I 205-213 disorder
 Evidence X-RAY 4w9d F Reference
       Region 4w9d F 54-61 disorder
       Region 4w9d F 62-205 order
       Region 4w9d F 206-213 disorder
 Evidence X-RAY 4w9d C Reference
       Region 4w9d C 54-61 disorder
       Region 4w9d C 62-202 order
       Region 4w9d C 203-213 disorder
 Evidence X-RAY 4w9c L Reference
       Region 4w9c L 54-61 disorder
       Region 4w9c L 62-204 order
       Region 4w9c L 205-213 disorder
 Evidence X-RAY 4w9c I Reference
       Region 4w9c I 54-61 disorder
       Region 4w9c I 62-204 order
       Region 4w9c I 205-213 disorder
 Evidence X-RAY 4w9c F Reference
       Region 4w9c F 54-61 disorder
       Region 4w9c F 62-205 order
       Region 4w9c F 206-213 disorder
 Evidence X-RAY 4w9c C Reference
       Region 4w9c C 54-61 disorder
       Region 4w9c C 62-202 order
       Region 4w9c C 203-213 disorder
 Evidence X-RAY 4b95 L Reference
       Region 4b95 L 54-61 disorder
       Region 4b95 L 62-142 order
       Region 4b95 L 143-146 disorder
       Region 4b95 L 147-205 order
       Region 4b95 L 206-213 disorder
 Evidence X-RAY 4b95 I Reference
       Region 4b95 I 54-61 disorder
       Region 4b95 I 62-205 order
       Region 4b95 I 206-213 disorder
 Evidence X-RAY 4b95 F Reference
       Region 4b95 F 54-62 disorder
       Region 4b95 F 63-139 order
       Region 4b95 F 140-141 disorder
       Region 4b95 F 142-203 order
       Region 4b95 F 204-213 disorder
 Evidence X-RAY 4b95 C Reference
       Region 4b95 C 54-61 disorder
       Region 4b95 C 62-138 order
       Region 4b95 C 139-146 disorder
       Region 4b95 C 147-203 order
       Region 4b95 C 204-213 disorder
Seq 54-213 Hetero pentamer : Q13617,Q15369
 Evidence X-RAY 5n4w V Reference
       Region 5n4w V 54-156 disorder
       Region 5n4w V 157-193 order
       Region 5n4w V 194-213 disorder
Seq 54-213 Hetero tetramer : IID00111Complex,Q15369,Q15370
 Evidence X-RAY 5t35 H Reference
       Region 5t35 H 54-60 disorder
       Region 5t35 H 61-207 order
       Region 5t35 H 208-213 disorder
 Evidence X-RAY 5t35 D Reference
       Region 5t35 D 54-60 disorder
       Region 5t35 D 61-209 order
       Region 5t35 D 210-213 disorder
Seq 54-213 Hetero trimer : Q15369
 Evidence X-RAY 3zrc C Reference
       Region 3zrc C 54-62 disorder
       Region 3zrc C 63-204 order
       Region 3zrc C 205-213 disorder
 Evidence X-RAY 1vcb L Reference
       Region 1vcb L 54-62 disorder
       Region 1vcb L 63-204 order
       Region 1vcb L 205-213 disorder
 Evidence X-RAY 1vcb I Reference
       Region 1vcb I 54-62 disorder
       Region 1vcb I 63-204 order
       Region 1vcb I 205-213 disorder
 Evidence X-RAY 1vcb F Reference
       Region 1vcb F 54-62 disorder
       Region 1vcb F 63-204 order
       Region 1vcb F 205-213 disorder
 Evidence X-RAY 1vcb C Reference
       Region 1vcb C 54-62 disorder
       Region 1vcb C 63-204 order
       Region 1vcb C 205-213 disorder
Seq 54-213 Hetero tetramer : IID00085Complex,Q15369,Q15370
 Evidence X-RAY 4ajy V Reference
       Region 4ajy V 54-59 disorder
       Region 4ajy V 60-207 order
       Region 4ajy V 208-213 disorder
 Evidence X-RAY 1lqb C Reference
       Region 1lqb C 54-60 disorder
       Region 1lqb C 61-210 order
       Region 1lqb C 211-213 disorder
 Evidence X-RAY 1lm8 V Reference
       Region 1lm8 V 54-59 disorder
       Region 1lm8 V 60-209 order
       Region 1lm8 V 210-213 disorder
 
Prediction
NeProc
Disorder 1-63,205-213
Order 64-204
ProS 1-12,21-28,53-63,205-213
AlphaFold
Disorder 1-57,213-213
Order 58-212
Pfam Hmmer
PF01847 58-213 1.6e-139
SEG 10-57
Function
Function in SwissProt
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
Biological Process
See also
Diagram with PDB data
HIF1A/VHL/ELOB/ELOCCrystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex
HIF1A/EP300NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex