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IID00374
 UniprotP55201
ProteinPeregrin
GeneBRPF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1214
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 274-450 Monomer :
 Evidence X-RAY 5erc A Reference
       Region 5erc A 274-427 order
       Region 5erc A 428-437 disorder
       Region 5erc A 438-450 order
Seq 622-738 Homo tetramer :
 Evidence X-RAY 5g4r D Reference
       Region 5g4r D 622-629 disorder
       Region 5g4r D 630-738 order
 Evidence X-RAY 5g4r C Reference
       Region 5g4r C 622-626 disorder
       Region 5g4r C 627-738 order
 Evidence X-RAY 5g4r B Reference
       Region 5g4r B 622-626 disorder
       Region 5g4r B 627-738 order
 Evidence X-RAY 5g4r A Reference
       Region 5g4r A 622-629 disorder
       Region 5g4r A 630-738 order
Seq 622-740 Monomer :
 Evidence X-RAY 5g4s A Reference
       Region 5g4s A 624-738 order
 Evidence X-RAY 5fg4 A Reference
       Region 5fg4 A 626-627 disorder
       Region 5fg4 A 628-740 order
 Evidence X-RAY 5dy7 A Reference
       Region 5dy7 A 626-626 disorder
       Region 5dy7 A 627-739 order
       Region 5dy7 A 740-740 disorder
 Evidence NMR 2d9e A Reference
       Region 2d9e A 633-740 order
 Evidence X-RAY 5c89 A Reference
       Region 5c89 A 627-739 order
       Region 5c89 A 740-740 disorder
 Evidence X-RAY 5c87 A Reference
       Region 5c87 A 626-627 disorder
       Region 5c87 A 628-739 order
       Region 5c87 A 740-740 disorder
 Evidence X-RAY 5c7n A Reference
       Region 5c7n A 626-627 disorder
       Region 5c7n A 628-739 order
       Region 5c7n A 740-740 disorder
 Evidence X-RAY 4uye B Reference
       Region 4uye B 622-628 disorder
       Region 4uye B 629-737 order
       Region 4uye B 738-738 disorder
 Evidence X-RAY 4uye A Reference
       Region 4uye A 622-628 disorder
       Region 4uye A 629-737 order
       Region 4uye A 738-738 disorder
 Evidence X-RAY 5t4v A Reference
       Region 5t4v A 627-627 disorder
       Region 5t4v A 628-739 order
       Region 5t4v A 740-740 disorder
 Evidence X-RAY 5t4u A Reference
       Region 5t4u A 627-627 disorder
       Region 5t4u A 628-739 order
       Region 5t4u A 740-740 disorder
 Evidence X-RAY 5myg D Reference
       Region 5myg D 626-629 disorder
       Region 5myg D 630-740 order
 Evidence X-RAY 5myg C Reference
       Region 5myg C 626-628 disorder
       Region 5myg C 629-740 order
 Evidence X-RAY 5myg B Reference
       Region 5myg B 626-740 order
 Evidence X-RAY 5myg A Reference
       Region 5myg A 626-740 order
 Evidence X-RAY 5mwz A Reference
       Region 5mwz A 626-739 order
       Region 5mwz A 740-740 disorder
 Evidence X-RAY 5mwh B Reference
       Region 5mwh B 626-627 disorder
       Region 5mwh B 628-739 order
       Region 5mwh B 740-740 disorder
 Evidence X-RAY 5mwh A Reference
       Region 5mwh A 626-627 disorder
       Region 5mwh A 628-739 order
       Region 5mwh A 740-740 disorder
 Evidence X-RAY 5mwg B Reference
       Region 5mwg B 626-627 disorder
       Region 5mwg B 628-739 order
       Region 5mwg B 740-740 disorder
 Evidence X-RAY 5mwg A Reference
       Region 5mwg A 626-629 disorder
       Region 5mwg A 630-739 order
       Region 5mwg A 740-740 disorder
 Evidence X-RAY 4lc2 A Reference
       Region 4lc2 A 626-626 disorder
       Region 4lc2 A 627-740 order
 Evidence X-RAY 5fg5 B Reference
       Region 5fg5 B 626-628 disorder
       Region 5fg5 B 629-736 order
       Region 5fg5 B 737-740 disorder
 Evidence X-RAY 5fg5 A Reference
       Region 5fg5 A 626-739 order
       Region 5fg5 A 740-740 disorder
 Evidence X-RAY 5ffy A Reference
       Region 5ffy A 626-628 disorder
       Region 5ffy A 629-739 order
       Region 5ffy A 740-740 disorder
 Evidence X-RAY 5eww A Reference
       Region 5eww A 626-626 disorder
       Region 5eww A 627-739 order
       Region 5eww A 740-740 disorder
 Evidence X-RAY 5ewv A Reference
       Region 5ewv A 626-626 disorder
       Region 5ewv A 627-739 order
       Region 5ewv A 740-740 disorder
 Evidence X-RAY 5ewh A Reference
       Region 5ewh A 626-626 disorder
       Region 5ewh A 627-739 order
       Region 5ewh A 740-740 disorder
 Evidence X-RAY 5ewd A Reference
       Region 5ewd A 626-626 disorder
       Region 5ewd A 627-739 order
       Region 5ewd A 740-740 disorder
 Evidence X-RAY 5ewc A Reference
       Region 5ewc A 626-627 disorder
       Region 5ewc A 628-739 order
       Region 5ewc A 740-740 disorder
 Evidence X-RAY 5eva A Reference
       Region 5eva A 626-626 disorder
       Region 5eva A 627-739 order
       Region 5eva A 740-740 disorder
 Evidence X-RAY 5ev9 A Reference
       Region 5ev9 A 626-627 disorder
       Region 5ev9 A 628-739 order
       Region 5ev9 A 740-740 disorder
 Evidence X-RAY 5etd A Reference
       Region 5etd A 626-627 disorder
       Region 5etd A 628-739 order
       Region 5etd A 740-740 disorder
 Evidence X-RAY 5etb A Reference
       Region 5etb A 626-627 disorder
       Region 5etb A 628-739 order
       Region 5etb A 740-740 disorder
 Evidence X-RAY 5eq1 A Reference
       Region 5eq1 A 626-627 disorder
       Region 5eq1 A 628-739 order
       Region 5eq1 A 740-740 disorder
 Evidence X-RAY 5eps A Reference
       Region 5eps A 627-739 order
       Region 5eps A 740-740 disorder
 Evidence X-RAY 5epr A Reference
       Region 5epr A 626-627 disorder
       Region 5epr A 628-739 order
       Region 5epr A 740-740 disorder
 Evidence X-RAY 5em3 A Reference
       Region 5em3 A 626-739 order
       Region 5em3 A 740-740 disorder
 Evidence X-RAY 5e3g A Reference
       Region 5e3g A 626-627 disorder
       Region 5e3g A 628-739 order
       Region 5e3g A 740-740 disorder
 Evidence X-RAY 5e3d A Reference
       Region 5e3d A 626-627 disorder
       Region 5e3d A 628-739 order
       Region 5e3d A 740-740 disorder
 Evidence X-RAY 5dyc A Reference
       Region 5dyc A 626-626 disorder
       Region 5dyc A 627-739 order
       Region 5dyc A 740-740 disorder
 Evidence X-RAY 5dya A Reference
       Region 5dya A 626-627 disorder
       Region 5dya A 628-739 order
       Region 5dya A 740-740 disorder
 Evidence X-RAY 5d7x A Reference
       Region 5d7x A 626-739 order
       Region 5d7x A 740-740 disorder
 Evidence X-RAY 5c85 A Reference
       Region 5c85 A 626-627 disorder
       Region 5c85 A 628-739 order
       Region 5c85 A 740-740 disorder
Seq 626-740 Hetero trimer : IID00058Complex
 Evidence X-RAY 5ffw B Reference
       Region 5ffw B 626-628 disorder
       Region 5ffw B 629-739 order
       Region 5ffw B 740-740 disorder
 Evidence X-RAY 5ffw A Reference
       Region 5ffw A 626-629 disorder
       Region 5ffw A 630-739 order
       Region 5ffw A 740-740 disorder
Seq 626-740 Hetero dimer : IID00062Complex
 Evidence X-RAY 5ffv B Reference
       Region 5ffv B 626-629 disorder
       Region 5ffv B 630-737 order
       Region 5ffv B 738-740 disorder
 Evidence X-RAY 5ffv A Reference
       Region 5ffv A 626-628 disorder
       Region 5ffv A 629-739 order
       Region 5ffv A 740-740 disorder
Seq 629-742 Hetero dimer : IID00058Complex
 Evidence X-RAY 4qyd A Reference
       Region 4qyd A 629-742 order
Seq 629-742 Hetero dimer : P0C0S8
 Evidence X-RAY 4qyl D Reference
       Region 4qyl D 629-742 order
 Evidence X-RAY 4qyl C Reference
       Region 4qyl C 629-742 order
 Evidence X-RAY 4qyl B Reference
       Region 4qyl B 629-742 order
 Evidence X-RAY 4qyl A Reference
       Region 4qyl A 629-742 order
Seq 633-740 Hetero dimer : IID00058Complex
 Evidence NMR 2rs9 B Reference
       Region 2rs9 B 633-740 order
Seq 1076-1207 Monomer :
 Evidence X-RAY 3l42 A Reference
       Region 3l42 A 1079-1205 order
       Region 3l42 A 1206-1207 disorder
 Evidence X-RAY 2x35 A Reference
       Region 2x35 A 1076-1079 disorder
       Region 2x35 A 1080-1204 order
       Region 2x35 A 1205-1205 disorder
 Evidence X-RAY 5c6s A Reference
       Region 5c6s A 1079-1204 order
       Region 5c6s A 1205-1207 disorder
Seq 1076-1207 Hetero dimer : IID00088Complex
 Evidence X-RAY 2x4y A Reference
       Region 2x4y A 1076-1078 disorder
       Region 2x4y A 1079-1205 order
 Evidence X-RAY 2x4y I Reference
       Region 2x4y I 1076-1079 disorder
       Region 2x4y I 1080-1204 order
       Region 2x4y I 1205-1205 disorder
 Evidence X-RAY 2x4y M Reference
       Region 2x4y M 1076-1079 disorder
       Region 2x4y M 1080-1205 order
 Evidence X-RAY 2x4y K Reference
       Region 2x4y K 1076-1079 disorder
       Region 2x4y K 1080-1205 order
 Evidence X-RAY 2x4y G Reference
       Region 2x4y G 1076-1079 disorder
       Region 2x4y G 1080-1203 order
       Region 2x4y G 1204-1205 disorder
 Evidence X-RAY 2x4y C Reference
       Region 2x4y C 1076-1079 disorder
       Region 2x4y C 1080-1204 order
       Region 2x4y C 1205-1205 disorder
 Evidence X-RAY 2x4y E Reference
       Region 2x4y E 1076-1079 disorder
       Region 2x4y E 1080-1205 order
 Evidence X-RAY 2x4y O Reference
       Region 2x4y O 1076-1079 disorder
       Region 2x4y O 1080-1202 order
       Region 2x4y O 1203-1205 disorder
 Evidence X-RAY 2x4x A Reference
       Region 2x4x A 1076-1079 disorder
       Region 2x4x A 1080-1205 order
 Evidence X-RAY 2x4x G Reference
       Region 2x4x G 1076-1081 disorder
       Region 2x4x G 1082-1203 order
       Region 2x4x G 1204-1205 disorder
 Evidence X-RAY 2x4x C Reference
       Region 2x4x C 1076-1079 disorder
       Region 2x4x C 1080-1204 order
       Region 2x4x C 1205-1205 disorder
 Evidence X-RAY 2x4x E Reference
       Region 2x4x E 1076-1079 disorder
       Region 2x4x E 1080-1205 order
 Evidence X-RAY 2x4w A Reference
       Region 2x4w A 1076-1079 disorder
       Region 2x4w A 1080-1204 order
       Region 2x4w A 1205-1205 disorder
 Evidence X-RAY 3mo8 A Reference
       Region 3mo8 A 1079-1204 order
       Region 3mo8 A 1205-1207 disorder
Seqphosphorylation
    1076-1076 Phosphoserine
    120-120 Phosphoserine
    238-238 Phosphoserine
    460-460 Phosphoserine
    462-462 Phosphoserine
    858-858 Phosphothreonine
    860-860 Phosphoserine
    917-917 Phosphoserine
    922-922 Phosphoserine
    926-926 Phosphoserine
    1187-1187 Phosphoserine
Seqacetylation
    147-147 N6-acetyllysine
    580-580 N6-acetyllysine
 
Prediction
NeProc
Disorder 46-90,126-174,450-503,562-581,749-1090,1200-1214
Order 1-45,91-121,175-449,504-561,582-748,1091-1133,1139-1199
ProS 46-52,87-90,148-154,450-477,498-503,754-775,786-793,807-824,924-931,965-973,1013-1024,1073-1090,1200-1206
AlphaFold
Disorder 1-3,51-90,92-92,103-106,116-180,183-191,194-194,198-200,260-273,285-285,428-435,451-483,486-487,490-490,501-501,504-515,552-552,562-578,750-779,801-803,827-1081,1204-1214
Order 4-50,91-91,93-102,107-115,181-182,192-193,195-197,201-259,274-284,286-427,436-450,484-485,488-489,491-500,502-503,516-551,553-561,579-749,780-800,804-826,1082-1203
Pfam Hmmer
PF00628 275-323 5.7e-12
PF00439 633-720 5e-35
SEG 74-85 ,117-135 ,161-167 ,207-221 ,462-500 ,756-769 ,857-871 ,903-913 ,942-966 ,993-1021
Function
Function in SwissProt
Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358).