IDEAL List

IDEAL

IID00376
UniprotP61956
ProteinSmall ubiquitin-related modifier 2
GeneSUMO2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 1-93 Hetero dimer : Q13569

Evidence X-RAY 2d07 B Reference

Region 2d07 B 1-14 disorder

Region 2d07 B 15-90 order

Region 2d07 B 91-93 disorder

Seq 1-93 Hetero dimer : IID00216Complex

Evidence NMR 2rpq A Reference

Region 2rpq A 1-93 order

Region 2rpq A 1-15 high_rmsd

Region 2rpq A 91-93 high_rmsd

Seq 1-95 Hetero dimer : Q96RL1

Evidence NMR 2n9e B Reference

Region 2n9e B 1-95 order

Region 2n9e B 1-9 high_rmsd

Region 2n9e B 95-95 high_rmsd

Seq 1-95 Monomer :

Evidence NMR 1wz0 A Reference

Region 1wz0 A 1-91 order

Region 1wz0 A 1-14 high_rmsd

Evidence NMR 2awt A Reference

Region 2awt A 1-95 order

Evidence NMR 2n1w A Reference

Region 2n1w A 1-93 order

Region 2n1w A 1-13 high_rmsd

Region 2n1w A 91-93 high_rmsd

Evidence NMR 5ghc A Reference

Region 5ghc A 1-93 order

Region 5ghc A 1-14 high_rmsd

Region 5ghc A 92-93 high_rmsd

Evidence NMR 5ghb A Reference

Region 5ghb A 1-93 order

Region 5ghb A 1-15 high_rmsd

Region 5ghb A 92-93 high_rmsd

Seq 12-89 Homo trimer :

Evidence X-RAY 1wm3 A Reference

Region 1wm3 A 17-88 order

Evidence X-RAY 1wm2 A Reference

Region 1wm2 A 12-89 order

Seq 12-93 Homo tetramer :

Evidence X-RAY 4npn A Reference

Region 4npn A 12-16 disorder

Region 4npn A 17-87 order

Region 4npn A 88-93 disorder

Seq 14-89 Hetero dimer :

Evidence X-RAY 5eql B Reference

Region 5eql B 14-89 order

Seq 14-89 Hetero dimer :

Evidence X-RAY 5elu B Reference

Region 5elu B 14-14 disorder

Region 5elu B 15-89 order

Seq 14-93 Hetero tetramer : IID00151Complex,P63279

Evidence X-RAY 3uio B Reference

Region 3uio B 14-14 disorder

Region 3uio B 15-93 order

Evidence X-RAY 3uin B Reference

Region 3uin B 14-15 disorder

Region 3uin B 16-93 order

Seq 15-93 Hetero dodecamer : P46060,Q9HC62

Evidence X-RAY 2io3 B Reference

Region 2io3 B 15-19 disorder

Region 2io3 B 20-93 order

Seq 15-93 Hetero pentamer : P63279,Q9Y4E5

Evidence X-RAY 5d2m E Reference

Region 5d2m E 15-93 order

Evidence X-RAY 5d2m B Reference

Region 5d2m B 15-17 disorder

Region 5d2m B 18-93 order

Seq 15-95 Hetero dimer : Q9HC62

Evidence X-RAY 3zo5 B Reference

Region 3zo5 B 16-95 order

Evidence X-RAY 2io0 B Reference

Region 2io0 B 15-15 disorder

Region 2io0 B 16-95 order

Seq 15-95 Hetero dimer : Q9P0U3

Evidence X-RAY 2iyd B Reference

Region 2iyd B 15-93 order

Region 2iyd B 94-95 disorder

Evidence X-RAY 2ckh B Reference

Region 2ckh B 15-93 order

Seqacetylation

11-11 N6-acetyllysine; alternate

Prediction

NeProc

Disorder 1-13

Order 14-95

AlphaFold

Disorder 1-15,90-95

Order 16-89

Pfam Hmmer

PF00240 21-91 1.2e-12

Function

Function in SwissProt

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).