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IID00377
 UniprotP61964
ProteinWD repeat-containing protein 5
GeneWDR5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
334
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-334 Monomer :
 Evidence X-RAY 5vfc A Reference
       Region 5vfc A 24-30 disorder
       Region 5vfc A 31-334 order
 Evidence X-RAY 3ur4 B Reference
       Region 3ur4 B 24-30 disorder
       Region 3ur4 B 31-210 order
       Region 3ur4 B 211-213 disorder
       Region 3ur4 B 214-334 order
 Evidence X-RAY 3ur4 A Reference
       Region 3ur4 A 24-30 disorder
       Region 3ur4 A 31-211 order
       Region 3ur4 A 212-212 disorder
       Region 3ur4 A 213-334 order
 Evidence X-RAY 5sxm B Reference
       Region 5sxm B 23-31 disorder
       Region 5sxm B 32-334 order
 Evidence X-RAY 5sxm A Reference
       Region 5sxm A 23-30 disorder
       Region 5sxm A 31-334 order
 Evidence X-RAY 3smr D Reference
       Region 3smr D 24-30 disorder
       Region 3smr D 31-210 order
       Region 3smr D 211-211 disorder
       Region 3smr D 212-334 order
 Evidence X-RAY 3smr C Reference
       Region 3smr C 24-30 disorder
       Region 3smr C 31-210 order
       Region 3smr C 211-211 disorder
       Region 3smr C 212-334 order
 Evidence X-RAY 3smr B Reference
       Region 3smr B 24-30 disorder
       Region 3smr B 31-211 order
       Region 3smr B 212-212 disorder
       Region 3smr B 213-334 order
 Evidence X-RAY 3smr A Reference
       Region 3smr A 24-30 disorder
       Region 3smr A 31-210 order
       Region 3smr A 211-212 disorder
       Region 3smr A 213-334 order
 Evidence X-RAY 4ql1 B Reference
       Region 4ql1 B 24-30 disorder
       Region 4ql1 B 31-210 order
       Region 4ql1 B 211-212 disorder
       Region 4ql1 B 213-334 order
 Evidence X-RAY 4ql1 A Reference
       Region 4ql1 A 24-30 disorder
       Region 4ql1 A 31-334 order
 Evidence X-RAY 3n0e A Reference
       Region 3n0e A 31-334 order
 Evidence X-RAY 3n0d A Reference
       Region 3n0d A 31-334 order
 Evidence X-RAY 3mxx A Reference
       Region 3mxx A 31-334 order
 Evidence X-RAY 5m25 A Reference
       Region 5m25 A 22-32 disorder
       Region 5m25 A 33-332 order
       Region 5m25 A 333-334 disorder
 Evidence X-RAY 5m23 A Reference
       Region 5m23 A 22-32 disorder
       Region 5m23 A 33-332 order
       Region 5m23 A 333-334 disorder
 Evidence X-RAY 4ia9 A Reference
       Region 4ia9 A 24-29 disorder
       Region 4ia9 A 30-334 order
 Evidence X-RAY 2h9l A Reference
       Region 2h9l A 24-334 order
 Evidence X-RAY 2h68 B Reference
       Region 2h68 B 23-28 disorder
       Region 2h68 B 29-334 order
 Evidence X-RAY 2h68 A Reference
       Region 2h68 A 23-30 disorder
       Region 2h68 A 31-334 order
 Evidence X-RAY 2h14 A Reference
       Region 2h14 A 22-31 disorder
       Region 2h14 A 32-334 order
 Evidence X-RAY 2gnq A Reference
       Region 2gnq A 1-10 disorder
       Region 2gnq A 11-18 order
       Region 2gnq A 19-26 disorder
       Region 2gnq A 27-334 order
 Evidence X-RAY 4gmb A Reference
       Region 4gmb A 22-27 disorder
       Region 4gmb A 28-334 order
 Evidence X-RAY 4gm9 B Reference
       Region 4gm9 B 22-24 disorder
       Region 4gm9 B 25-334 order
 Evidence X-RAY 4gm9 A Reference
       Region 4gm9 A 22-23 disorder
       Region 4gm9 A 24-210 order
       Region 4gm9 A 211-212 disorder
       Region 4gm9 A 213-334 order
 Evidence X-RAY 4gm8 D Reference
       Region 4gm8 D 22-30 disorder
       Region 4gm8 D 31-210 order
       Region 4gm8 D 211-214 disorder
       Region 4gm8 D 215-334 order
 Evidence X-RAY 4gm8 C Reference
       Region 4gm8 C 22-30 disorder
       Region 4gm8 C 31-210 order
       Region 4gm8 C 211-212 disorder
       Region 4gm8 C 213-334 order
 Evidence X-RAY 4gm8 B Reference
       Region 4gm8 B 22-32 disorder
       Region 4gm8 B 33-210 order
       Region 4gm8 B 211-212 disorder
       Region 4gm8 B 213-334 order
 Evidence X-RAY 4gm8 A Reference
       Region 4gm8 A 22-30 disorder
       Region 4gm8 A 31-210 order
       Region 4gm8 A 211-212 disorder
       Region 4gm8 A 213-334 order
 Evidence X-RAY 4gm3 H Reference
       Region 4gm3 H 22-30 disorder
       Region 4gm3 H 31-334 order
 Evidence X-RAY 4gm3 G Reference
       Region 4gm3 G 22-30 disorder
       Region 4gm3 G 31-334 order
 Evidence X-RAY 4gm3 F Reference
       Region 4gm3 F 22-30 disorder
       Region 4gm3 F 31-334 order
 Evidence X-RAY 4gm3 E Reference
       Region 4gm3 E 22-30 disorder
       Region 4gm3 E 31-334 order
 Evidence X-RAY 4gm3 D Reference
       Region 4gm3 D 22-30 disorder
       Region 4gm3 D 31-334 order
 Evidence X-RAY 4gm3 C Reference
       Region 4gm3 C 22-30 disorder
       Region 4gm3 C 31-334 order
 Evidence X-RAY 4gm3 B Reference
       Region 4gm3 B 22-30 disorder
       Region 4gm3 B 31-334 order
 Evidence X-RAY 4gm3 A Reference
       Region 4gm3 A 22-30 disorder
       Region 4gm3 A 31-334 order
 Evidence X-RAY 5ear B Reference
       Region 5ear B 24-30 disorder
       Region 5ear B 31-211 order
       Region 5ear B 212-214 disorder
       Region 5ear B 215-334 order
 Evidence X-RAY 5ear A Reference
       Region 5ear A 24-30 disorder
       Region 5ear A 31-210 order
       Region 5ear A 211-213 disorder
       Region 5ear A 214-334 order
 Evidence X-RAY 5eap A Reference
       Region 5eap A 24-211 order
       Region 5eap A 212-213 disorder
       Region 5eap A 214-334 order
 Evidence X-RAY 5eam B Reference
       Region 5eam B 24-30 disorder
       Region 5eam B 31-334 order
 Evidence X-RAY 5eam A Reference
       Region 5eam A 24-30 disorder
       Region 5eam A 31-334 order
 Evidence X-RAY 5eal B Reference
       Region 5eal B 24-30 disorder
       Region 5eal B 31-334 order
 Evidence X-RAY 5eal A Reference
       Region 5eal A 24-30 disorder
       Region 5eal A 31-334 order
Seq 20-334 Hetero dimer : IID00062Complex
 Evidence X-RAY 2co0 C Reference
       Region 2co0 C 20-30 disorder
       Region 2co0 C 31-334 order
 Evidence X-RAY 2co0 A Reference
       Region 2co0 A 20-30 disorder
       Region 2co0 A 31-334 order
 Evidence X-RAY 4a7j A Reference
       Region 4a7j A 21-31 disorder
       Region 4a7j A 32-334 order
Seq 20-334 Hetero dimer : IID50143Complex
 Evidence X-RAY 2cnx A Reference
       Region 2cnx A 20-28 disorder
       Region 2cnx A 29-334 order
Seq 21-334 Hetero dimer :
 Evidence X-RAY 3psl B Reference
       Region 3psl B 21-31 disorder
       Region 3psl B 32-209 order
       Region 3psl B 210-214 disorder
       Region 3psl B 215-334 order
Seq 21-334 Hetero dimer :
 Evidence X-RAY 3psl A Reference
       Region 3psl A 21-31 disorder
       Region 3psl A 32-209 order
       Region 3psl A 210-214 disorder
       Region 3psl A 215-334 order
Seq 21-334 Hetero dimer : IID00402Complex
 Evidence X-RAY 3uvo A Reference
       Region 3uvo A 21-30 disorder
       Region 3uvo A 31-210 order
       Region 3uvo A 211-214 disorder
       Region 3uvo A 215-334 order
 Evidence X-RAY 4es0 A Reference
       Region 4es0 A 23-30 disorder
       Region 4es0 A 31-334 order
Seq 21-334 Hetero dimer : IID00389Complex
 Evidence X-RAY 3uvl A Reference
       Region 3uvl A 21-30 disorder
       Region 3uvl A 31-210 order
       Region 3uvl A 211-211 disorder
       Region 3uvl A 212-334 order
 Evidence X-RAY 4ery A Reference
       Region 4ery A 23-30 disorder
       Region 4ery A 31-334 order
Seq 21-334 Hetero dimer : IID00356Complex
 Evidence X-RAY 3uvk A Reference
       Region 3uvk A 21-30 disorder
       Region 3uvk A 31-209 order
       Region 3uvk A 210-212 disorder
       Region 3uvk A 213-242 order
       Region 3uvk A 243-244 disorder
       Region 3uvk A 245-334 order
 Evidence X-RAY 4erq C Reference
       Region 4erq C 23-30 disorder
       Region 4erq C 31-334 order
 Evidence X-RAY 4erq B Reference
       Region 4erq B 23-30 disorder
       Region 4erq B 31-334 order
 Evidence X-RAY 4erq A Reference
       Region 4erq A 23-30 disorder
       Region 4erq A 31-334 order
Seq 21-334 Hetero dimer : IID00358Complex
 Evidence X-RAY 3uvn C Reference
       Region 3uvn C 21-30 disorder
       Region 3uvn C 31-334 order
 Evidence X-RAY 3uvn A Reference
       Region 3uvn A 21-30 disorder
       Region 3uvn A 31-334 order
 Evidence X-RAY 4ewr A Reference
       Region 4ewr A 23-30 disorder
       Region 4ewr A 31-334 order
Seq 21-334 Hetero dimer : IID00400Complex
 Evidence X-RAY 3uvm A Reference
       Region 3uvm A 21-30 disorder
       Region 3uvm A 31-334 order
 Evidence X-RAY 4erz C Reference
       Region 4erz C 23-30 disorder
       Region 4erz C 31-334 order
 Evidence X-RAY 4erz B Reference
       Region 4erz B 23-30 disorder
       Region 4erz B 31-334 order
 Evidence X-RAY 4erz A Reference
       Region 4erz A 23-30 disorder
       Region 4erz A 31-334 order
Seq 22-334 Hetero dimer : IID00012Complex
 Evidence X-RAY 4y7r A Reference
       Region 4y7r A 22-30 disorder
       Region 4y7r A 31-334 order
Seq 22-334 Hetero dimer :
 Evidence X-RAY 2h13 A Reference
       Region 2h13 A 22-31 disorder
       Region 2h13 A 32-334 order
Seq 22-334 Hetero trimer : IID00379Complex,IID00387Complex
 Evidence X-RAY 3p4f A Reference
       Region 3p4f A 22-30 disorder
       Region 3p4f A 31-334 order
Seq 23-334 Hetero dimer : Q7Z3B3
 Evidence X-RAY 4cy1 B Reference
       Region 4cy1 B 23-31 disorder
       Region 4cy1 B 32-211 order
       Region 4cy1 B 212-213 disorder
       Region 4cy1 B 214-334 order
 Evidence X-RAY 4cy1 A Reference
       Region 4cy1 A 23-30 disorder
       Region 4cy1 A 31-212 order
       Region 4cy1 A 213-213 disorder
       Region 4cy1 A 214-334 order
Seq 23-334 Hetero dimer :
 Evidence X-RAY 2h6k A Reference
       Region 2h6k A 23-29 disorder
       Region 2h6k A 30-334 order
Seq 23-334 Hetero dimer :
 Evidence X-RAY 2h6q B Reference
       Region 2h6q B 23-30 disorder
       Region 2h6q B 31-334 order
Seq 23-334 Hetero dimer :
 Evidence X-RAY 2h6n A Reference
       Region 2h6n A 23-30 disorder
       Region 2h6n A 31-334 order
Seq 23-334 Hetero trimer : Q7Z3B3,Q9H9L4
 Evidence X-RAY 4cy2 A Reference
       Region 4cy2 A 23-30 disorder
       Region 4cy2 A 31-334 order
Seq 23-334 Hetero dimer :
 Evidence X-RAY 2h6k B Reference
       Region 2h6k B 23-28 disorder
       Region 2h6k B 29-334 order
Seq 23-334 Hetero dimer : IID00379Complex
 Evidence X-RAY 4esg B Reference
       Region 4esg B 23-30 disorder
       Region 4esg B 31-334 order
 Evidence X-RAY 4esg A Reference
       Region 4esg A 23-30 disorder
       Region 4esg A 31-334 order
Seq 23-334 Hetero dimer : IID00379Complex
 Evidence X-RAY 3emh A Reference
       Region 3emh A 25-32 disorder
       Region 3emh A 33-332 order
       Region 3emh A 333-334 disorder
 Evidence X-RAY 3eg6 A Reference
       Region 3eg6 A 23-30 disorder
       Region 3eg6 A 31-334 order
Seq 23-334 Hetero dimer :
 Evidence X-RAY 2h6q A Reference
       Region 2h6q A 23-30 disorder
       Region 2h6q A 31-334 order
Seq 23-334 Hetero dimer :
 Evidence X-RAY 2h6n B Reference
       Region 2h6n B 23-29 disorder
       Region 2h6n B 30-334 order
Seq 24-334 Hetero dimer :
 Evidence X-RAY 2o9k C Reference
       Region 2o9k C 24-30 disorder
       Region 2o9k C 31-211 order
       Region 2o9k C 212-212 disorder
       Region 2o9k C 213-334 order
Seq 24-334 Hetero dimer :
 Evidence X-RAY 2o9k A Reference
       Region 2o9k A 24-30 disorder
       Region 2o9k A 31-334 order
Seq 24-334 Hetero dimer : Q6P823
 Evidence X-RAY 2h9p A Reference
       Region 2h9p A 24-30 disorder
       Region 2h9p A 31-334 order
 Evidence X-RAY 2h9n C Reference
       Region 2h9n C 24-30 disorder
       Region 2h9n C 31-334 order
 Evidence X-RAY 2h9n A Reference
       Region 2h9n A 24-30 disorder
       Region 2h9n A 31-334 order
 Evidence X-RAY 2h9m C Reference
       Region 2h9m C 24-30 disorder
       Region 2h9m C 31-334 order
 Evidence X-RAY 2h9m A Reference
       Region 2h9m A 24-30 disorder
       Region 2h9m A 31-334 order
Seq 24-334 Hetero dimer : P03495
 Evidence X-RAY 4o45 A Reference
       Region 4o45 A 24-29 disorder
       Region 4o45 A 30-334 order
Seq 27-334 Hetero dimer :
 Evidence X-RAY 2g99 B Reference
       Region 2g99 B 27-29 disorder
       Region 2g99 B 30-333 order
       Region 2g99 B 334-334 disorder
Seq 27-334 Hetero dimer :
 Evidence X-RAY 2g99 A Reference
       Region 2g99 A 27-29 disorder
       Region 2g99 A 30-333 order
       Region 2g99 A 334-334 disorder
Seq 29-334 Hetero dimer :
 Evidence X-RAY 2g9a A Reference
       Region 2g9a A 29-333 order
       Region 2g9a A 334-334 disorder
Seqacetylation
    112-112 N6-acetyllysine
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-23
Order 24-334
ProS 23-23
AlphaFold
Disorder 1-28,30-30
Order 29-29,31-334
Pfam Hmmer
PF00400 35-73 9.5e-12
PF00400 77-115 1.9e-11
PF00400 119-157 4.6e-13
PF00400 161-199 2.6e-12
PF00400 203-242 9.8e-07
PF00400 246-287 2e-07
SEG 2-15
Function
Function in SwissProt
Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).