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IID00381
 UniprotQ06455
ProteinProtein CBFA2T1
GeneRUNX1T1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
604
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 119-216 Hetero dimer : IID00222Complex
 Evidence NMR 2knh A Reference
       Region 2knh A 119-216 order
       Region 2knh A 202-216 high_rmsd
Seq 119-225 Monomer :
 Evidence NMR 2pp4 A Reference
       Region 2pp4 A 119-225 order
       Region 2pp4 A 221-225 high_rmsd
 Evidence NMR 2h7b A Reference
       Region 2h7b A 120-222 order
       Region 2h7b A 215-222 high_rmsd
Seq 335-403 Homo tetramer :
 Evidence X-RAY 1wq6 B Reference
       Region 1wq6 B 335-341 disorder
       Region 1wq6 B 342-400 order
       Region 1wq6 B 401-403 disorder
 Evidence X-RAY 1wq6 A Reference
       Region 1wq6 A 335-341 disorder
       Region 1wq6 A 342-400 order
       Region 1wq6 A 401-403 disorder
Seq 338-400 Hetero tetramer : IID00222Complex
 Evidence X-RAY 4jol D Reference
       Region 4jol D 338-340 disorder
       Region 4jol D 341-400 order
 Evidence X-RAY 4jol B Reference
       Region 4jol B 338-340 disorder
       Region 4jol B 341-400 order
 Evidence X-RAY 4jol C Reference
       Region 4jol C 338-340 disorder
       Region 4jol C 341-400 order
 Evidence X-RAY 4jol A Reference
       Region 4jol A 338-340 disorder
       Region 4jol A 341-400 order
Seqdisorder 437-467
 Evidence CD Reference
       Region 437-467 disorder
Seq 437-467 Hetero trimer : IID00411Complex
 Evidence NMR 2kyg C Reference
       Region 2kyg C 437-467 order
       Region 2kyg C 437-438 high_rmsd
Seq 505-559 Monomer :
 Evidence NMR 2od1 A Reference
       Region 2od1 A 510-559 order
       Region 2od1 A 510-511 high_rmsd
       Region 2od1 A 553-559 high_rmsd
 Evidence NMR 2dj8 A Reference
       Region 2dj8 A 505-551 order
       Region 2dj8 A 505-511 high_rmsd
Seq 510-559 Hetero dimer : IID00109Complex
 Evidence NMR 2odd A Reference
       Region 2odd A 510-559 order
       Region 2odd A 510-511 high_rmsd
       Region 2odd A 554-559 high_rmsd
SeqProS verified 437-467 Hetero trimer : IID00411Complex
       Region 2kyg C 437-467 order
       Region 437-467 disorder
Seqphosphorylation
    41-41 Phosphoserine
    417-417 Phosphoserine
 
Prediction
NeProc
Disorder 1-139,197-362,380-441,509-510,550-604
Order 145-196,363-370,375-379,442-508,511-549
ProS 1-30,121-139,197-204,229-249,263-269,287-295,301-305,312-321,326-332,350-362,380-396,425-441,550-554
AlphaFold
Disorder 1-120,216-341,402-440,508-512,557-602,604-604
Order 121-215,342-401,441-507,513-556,603-603
Pfam Hmmer
PF07531 120-215 1.9e-52
PF01753 515-551 1.9e-17
SEG 52-62 ,88-116 ,286-297 ,405-413 ,582-603
Function
Function in SwissProt
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588).