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IID00382
 UniprotQ07869
ProteinPeroxisome proliferator-activated receptor alpha
GenePPARA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
468
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 192-468 Hetero dimer : IID00083Complex
 Evidence X-RAY 2p54 A Reference
       Region 2p54 A 202-468 order
 Evidence X-RAY 2npa C Reference
       Region 2npa C 199-259 order
       Region 2npa C 260-262 disorder
       Region 2npa C 263-468 order
 Evidence X-RAY 2npa A Reference
       Region 2npa A 199-467 order
       Region 2npa A 468-468 disorder
 Evidence X-RAY 1k7l G Reference
       Region 1k7l G 192-201 disorder
       Region 1k7l G 202-468 order
 Evidence X-RAY 1k7l E Reference
       Region 1k7l E 192-201 disorder
       Region 1k7l E 202-468 order
 Evidence X-RAY 1k7l C Reference
       Region 1k7l C 192-201 disorder
       Region 1k7l C 202-468 order
 Evidence X-RAY 1k7l A Reference
       Region 1k7l A 192-201 disorder
       Region 1k7l A 202-468 order
 Evidence X-RAY 3et1 B Reference
       Region 3et1 B 199-468 order
 Evidence X-RAY 3et1 A Reference
       Region 3et1 A 199-256 order
       Region 3et1 A 257-263 disorder
       Region 3et1 A 264-468 order
Seq 195-468 Monomer :
 Evidence X-RAY 5hyk A Reference
       Region 5hyk A 200-201 disorder
       Region 5hyk A 202-230 order
       Region 5hyk A 231-237 disorder
       Region 5hyk A 238-259 order
       Region 5hyk A 260-264 disorder
       Region 5hyk A 265-468 order
 Evidence X-RAY 2znn A Reference
       Region 2znn A 200-201 disorder
       Region 2znn A 202-230 order
       Region 2znn A 231-237 disorder
       Region 2znn A 238-262 order
       Region 2znn A 263-264 disorder
       Region 2znn A 265-468 order
 Evidence X-RAY 3vi8 A Reference
       Region 3vi8 A 200-201 disorder
       Region 3vi8 A 202-230 order
       Region 3vi8 A 231-237 disorder
       Region 3vi8 A 238-262 order
       Region 3vi8 A 263-264 disorder
       Region 3vi8 A 265-468 order
 Evidence X-RAY 2rew A Reference
       Region 2rew A 196-198 disorder
       Region 2rew A 199-231 order
       Region 2rew A 232-236 disorder
       Region 2rew A 237-254 order
       Region 2rew A 255-263 disorder
       Region 2rew A 264-467 order
       Region 2rew A 468-468 disorder
 Evidence X-RAY 1i7g A Reference
       Region 1i7g A 196-198 disorder
       Region 1i7g A 199-231 order
       Region 1i7g A 232-233 disorder
       Region 1i7g A 234-254 order
       Region 1i7g A 255-263 disorder
       Region 1i7g A 264-468 order
 Evidence X-RAY 4ci4 A Reference
       Region 4ci4 A 195-203 disorder
       Region 4ci4 A 204-230 order
       Region 4ci4 A 231-236 disorder
       Region 4ci4 A 237-255 order
       Region 4ci4 A 256-265 disorder
       Region 4ci4 A 266-467 order
       Region 4ci4 A 468-468 disorder
 Evidence X-RAY 4bcr B Reference
       Region 4bcr B 195-195 disorder
       Region 4bcr B 196-230 order
       Region 4bcr B 231-237 disorder
       Region 4bcr B 238-467 order
       Region 4bcr B 468-468 disorder
 Evidence X-RAY 4bcr A Reference
       Region 4bcr A 195-203 disorder
       Region 4bcr A 204-466 order
       Region 4bcr A 467-468 disorder
Seq 196-468 Homo dimer :
 Evidence X-RAY 3kdt B Reference
       Region 3kdt B 196-233 order
       Region 3kdt B 234-234 disorder
       Region 3kdt B 235-255 order
       Region 3kdt B 256-258 disorder
       Region 3kdt B 259-467 order
       Region 3kdt B 468-468 disorder
 Evidence X-RAY 3kdt A Reference
       Region 3kdt A 196-197 disorder
       Region 3kdt A 198-256 order
       Region 3kdt A 257-262 disorder
       Region 3kdt A 263-467 order
       Region 3kdt A 468-468 disorder
Seq 196-468 Homo dimer :
 Evidence X-RAY 3kdu B Reference
       Region 3kdu B 196-233 order
       Region 3kdu B 234-234 disorder
       Region 3kdu B 235-255 order
       Region 3kdu B 256-258 disorder
       Region 3kdu B 259-467 order
       Region 3kdu B 468-468 disorder
 Evidence X-RAY 3kdu A Reference
       Region 3kdu A 196-197 disorder
       Region 3kdu A 198-256 order
       Region 3kdu A 257-262 disorder
       Region 3kdu A 263-467 order
       Region 3kdu A 468-468 disorder
Seq 196-468 Hetero dimer : Q86YN6
 Evidence X-RAY 3sp6 A Reference
       Region 3sp6 A 196-261 order
       Region 3sp6 A 262-264 disorder
       Region 3sp6 A 265-468 order
Seq 199-468 Hetero dimer : IID00083Complex
 Evidence X-RAY 3g8i A Reference
       Region 3g8i A 199-201 disorder
       Region 3g8i A 202-230 order
       Region 3g8i A 231-236 disorder
       Region 3g8i A 237-258 order
       Region 3g8i A 259-265 disorder
       Region 3g8i A 266-468 order
 Evidence X-RAY 3fei A Reference
       Region 3fei A 202-230 order
       Region 3fei A 231-237 disorder
       Region 3fei A 238-251 order
       Region 3fei A 252-265 disorder
       Region 3fei A 266-468 order
Seq 200-468 Hetero dimer : IID00109Complex
 Evidence X-RAY 1kkq D Reference
       Region 1kkq D 200-468 order
 Evidence X-RAY 1kkq C Reference
       Region 1kkq C 200-468 order
 Evidence X-RAY 1kkq B Reference
       Region 1kkq B 200-468 order
 Evidence X-RAY 1kkq A Reference
       Region 1kkq A 200-468 order
Seq 201-468 Hetero trimer : IID00083Complex
 Evidence X-RAY 5azt B Reference
       Region 5azt B 201-203 disorder
       Region 5azt B 204-234 order
       Region 5azt B 235-235 disorder
       Region 5azt B 236-254 order
       Region 5azt B 255-265 disorder
       Region 5azt B 266-466 order
       Region 5azt B 467-468 disorder
 Evidence X-RAY 5azt A Reference
       Region 5azt A 201-203 disorder
       Region 5azt A 204-229 order
       Region 5azt A 230-233 disorder
       Region 5azt A 234-468 order
 
Prediction
NeProc
Disorder 1-98,179-268
Order 99-178,269-468
ProS 1-25,48-52,66-71,83-86,179-185,208-229,235-246
AlphaFold
Disorder 1-98,174-174,188-199,234-234,258-262,264-264,468-468
Order 99-173,175-187,200-233,235-257,263-263,265-467
Pfam Hmmer
PF00105 100-174 1.6e-47
PF00104 281-463 1.5e-36
SEG 73-90
Function
Function in SwissProt
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment