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IID00388
 UniprotQ8NBT2
ProteinKinetochore protein Spc24
GeneSPC24
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
197
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 122-197 Hetero dimer : IID00184Complex,IID00393Complex,IID00395Complex
 Evidence X-RAY 2ve7 C Reference
       Region 2ve7 C 122-132 disorder
       Region 2ve7 C 133-164 order
       Region 2ve7 C 165-170 disorder
       Region 2ve7 C 171-193 order
       Region 2ve7 C 194-197 disorder
Seq 122-197 Hetero dimer : IID00184Complex,IID00393Complex,IID00395Complex
 Evidence X-RAY 2ve7 D Reference
       Region 2ve7 D 122-197 order
Seqphosphorylation
    11-11 Phosphoserine
 
Prediction
NeProc
Disorder 33-65
Order 1-32,66-197
ProS 33-65
AlphaFold
Disorder 1-5
Order 6-197
Pfam Hmmer
PF08286 80-193 8.1e-43
Function
Function in SwissProt
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).