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IID00393
 UniprotQ9BZD4
ProteinKinetochore protein Nuf2
GeneNUF2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
464
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-169 Hetero dimer : IID00184Complex,IID00388Complex,IID00395Complex
 Evidence X-RAY 2ve7 C Reference
       Region 2ve7 C 1-3 disorder
       Region 2ve7 C 4-167 order
       Region 2ve7 C 168-169 disorder
Seq 1-169 Hetero dimer : IID00184Complex,IID00388Complex,IID00395Complex
 Evidence X-RAY 2ve7 D Reference
       Region 2ve7 D 1-3 disorder
       Region 2ve7 D 4-169 order
Seqphosphorylation
    247-247 Phosphoserine
    171-171 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 448-464
Order 1-447
ProS 448-464
AlphaFold
Disorder 1-4,241-252,254-254,454-464
Order 5-240,253-253,255-453
Pfam Hmmer
PF03800 1-148 1.2e-104
Function
Function in SwissProt
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).