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IID00394
 UniprotQ9GZU7
ProteinCarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
GeneCTDSP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
261
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 77-256 Hetero dimer : IID00126Complex
 Evidence X-RAY 2ghq A Reference
       Region 2ghq A 77-256 order
 Evidence X-RAY 2ghq B Reference
       Region 2ghq B 77-256 order
 Evidence X-RAY 2ght A Reference
       Region 2ght A 77-256 order
 Evidence X-RAY 2ght B Reference
       Region 2ght B 77-256 order
Seq 77-261 Monomer :
 Evidence X-RAY 1t9z A Reference
       Region 1t9z A 77-256 order
       Region 1t9z A 257-261 disorder
 Evidence X-RAY 1ta0 A Reference
       Region 1ta0 A 77-256 order
       Region 1ta0 A 257-261 disorder
 Evidence X-RAY 3l0b A Reference
       Region 3l0b A 77-256 order
 Evidence X-RAY 3l0b B Reference
       Region 3l0b B 77-256 order
 Evidence X-RAY 3l0c A Reference
       Region 3l0c A 77-255 order
       Region 3l0c A 256-256 disorder
 Evidence X-RAY 3l0c B Reference
       Region 3l0c B 77-255 order
       Region 3l0c B 256-256 disorder
 Evidence X-RAY 3l0y A Reference
       Region 3l0y A 77-255 order
       Region 3l0y A 256-256 disorder
 Evidence X-RAY 3l0y B Reference
       Region 3l0y B 77-255 order
       Region 3l0y B 256-256 disorder
 Evidence X-RAY 3pgl A Reference
       Region 3pgl A 77-256 order
 Evidence X-RAY 3pgl B Reference
       Region 3pgl B 77-256 order
 Evidence X-RAY 4ygy A A peptide also bound to this region. Reference
       Region 4ygy A 77-255 order
       Region 4ygy A 256-261 disorder
 Evidence X-RAY 4ygy B A peptide also bound to this region. Reference
       Region 4ygy B 77-255 order
       Region 4ygy B 256-261 disorder
 Evidence X-RAY 4yh1 A A peptide also bound to this region. Reference
       Region 4yh1 A 77-255 order
 Evidence X-RAY 4yh1 B A peptide also bound to this region. Reference
       Region 4yh1 B 77-255 order
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-76,258-261
Order 77-257
ProS 4-16,35-50,66-70
AlphaFold
Disorder 1-4,8-74,257-261
Order 5-7,75-256
Pfam Hmmer
PF03031 82-256 2e-95
Function
Function in SwissProt
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Biological Process
See also
Diagram with PDB data
REST/CTDSP1Structure of Scp1 D96N bound to REST-pS861/4 peptide