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IID00395
 UniprotQ9HBM1
ProteinKinetochore protein Spc25
GeneSPC25
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
224
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 118-223 Hetero dimer : IID00184Complex,IID00388Complex,IID00393Complex
 Evidence X-RAY 2ve7 A Reference
       Region 2ve7 A 118-147 order
       Region 2ve7 A 148-157 disorder
       Region 2ve7 A 158-161 order
       Region 2ve7 A 162-164 disorder
       Region 2ve7 A 165-170 order
       Region 2ve7 A 171-214 disorder
       Region 2ve7 A 215-221 order
       Region 2ve7 A 222-223 disorder
Seq 118-223 Hetero dimer : IID00184Complex,IID00388Complex,IID00393Complex
 Evidence X-RAY 2ve7 B Reference
       Region 2ve7 B 118-188 order
       Region 2ve7 B 189-192 disorder
       Region 2ve7 B 193-223 order
Seqphosphorylation
    12-12 Phosphoserine
 
Prediction
NeProc
Order 1-224
AlphaFold
Disorder 1-2,27-27,224-224
Order 3-26,28-223
Pfam Hmmer
PF08234 138-218 6.2e-42
Function
Function in SwissProt
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).