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IID00396
 UniprotQ9NWT6
ProteinHypoxia-inducible factor 1-alpha inhibitor
GeneHIF1AN
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
349
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-349 Hetero tetramer : Q9H2K2
 Evidence X-RAY 2y0i A Reference
       Region 2y0i A 1-10 disorder
       Region 2y0i A 11-349 order
Seq 1-349 Hetero dimer :
 Evidence X-RAY 2xum A Reference
       Region 2xum A 1-349 order
Seq 1-349 Hetero tetramer :
 Evidence X-RAY 2xum A Reference
       Region 2xum A 1-349 order
Seq 1-349 Hetero tetramer : IID00085Complex
 Evidence X-RAY 1h2k A Reference
       Region 1h2k A 1-14 disorder
       Region 1h2k A 15-303 order
       Region 1h2k A 304-306 disorder
       Region 1h2k A 307-349 order
 Evidence X-RAY 1h2l A Reference
       Region 1h2l A 1-14 disorder
       Region 1h2l A 15-303 order
       Region 1h2l A 304-306 disorder
       Region 1h2l A 307-349 order
 Evidence X-RAY 1h2m A Reference
       Region 1h2m A 1-14 disorder
       Region 1h2m A 15-303 order
       Region 1h2m A 304-306 disorder
       Region 1h2m A 307-349 order
Seq 1-349 Hetero tetramer : Q01705
 Evidence X-RAY 3p3p A Reference
       Region 3p3p A 1-8 disorder
       Region 3p3p A 9-349 order
Seq 1-349 Hetero tetramer : IID00085Complex
 Evidence X-RAY 5jwp A Reference
       Region 5jwp A 1-7 disorder
       Region 5jwp A 8-349 order
Seq 1-349 Hetero tetramer :
 Evidence X-RAY 4b7k A Reference
       Region 4b7k A 1-11 disorder
       Region 4b7k A 12-349 order
Seq 1-349 Hetero tetramer :
 Evidence X-RAY 4b7e A Reference
       Region 4b7e A 1-349 order
Seq 1-349 Monomer :
 Evidence X-RAY 2cgn A Reference
       Region 2cgn A 1-2 disorder
       Region 2cgn A 3-111 order
       Region 2cgn A 112-118 disorder
       Region 2cgn A 119-138 order
       Region 2cgn A 139-140 disorder
       Region 2cgn A 141-349 order
 Evidence X-RAY 2cgo A Reference
       Region 2cgo A 1-7 disorder
       Region 2cgo A 8-115 order
       Region 2cgo A 116-118 disorder
       Region 2cgo A 119-349 order
 Evidence X-RAY 2wa3 A Reference
       Region 2wa3 A 1-14 disorder
       Region 2wa3 A 15-349 order
 Evidence X-RAY 2wa4 A Reference
       Region 2wa4 A 1-14 disorder
       Region 2wa4 A 15-303 order
       Region 2wa4 A 304-306 disorder
       Region 2wa4 A 307-349 order
 Evidence X-RAY 5op6 A Reference
       Region 5op6 A 1-14 disorder
       Region 5op6 A 15-116 order
       Region 5op6 A 117-118 disorder
       Region 5op6 A 119-349 order
 Evidence X-RAY 5op8 A Reference
       Region 5op8 A 1-14 disorder
       Region 5op8 A 15-349 order
Seq 1-349 Hetero dimer :
 Evidence X-RAY 4nr1 A Reference
       Region 4nr1 A 1-14 disorder
       Region 4nr1 A 15-349 order
Seq 1-349 Hetero tetramer : Q01705
 Evidence X-RAY 3p3n A Reference
       Region 3p3n A 1-8 disorder
       Region 3p3n A 9-349 order
Seq 1-349 Hetero dimer :
 Evidence X-RAY 4jaa A Reference
       Region 4jaa A 1-21 disorder
       Region 4jaa A 22-349 order
Seq 1-349 Hetero tetramer : IID00085Complex
 Evidence X-RAY 2ilm A Reference
       Region 2ilm A 1-7 disorder
       Region 2ilm A 8-304 order
       Region 2ilm A 305-305 disorder
       Region 2ilm A 306-349 order
Seq 1-349 Homo dimer :
 Evidence X-RAY 1h2n A Reference
       Region 1h2n A 1-14 disorder
       Region 1h2n A 15-303 order
       Region 1h2n A 304-306 disorder
       Region 1h2n A 307-349 order
 Evidence X-RAY 1iz3 A Reference
       Region 1iz3 A 1-11 disorder
       Region 1iz3 A 12-349 order
 Evidence X-RAY 1mze A Reference
       Region 1mze A 1-12 disorder
       Region 1mze A 13-303 order
       Region 1mze A 304-305 disorder
       Region 1mze A 306-349 order
 Evidence X-RAY 1mzf A Reference
       Region 1mzf A 1-12 disorder
       Region 1mzf A 13-137 order
       Region 1mzf A 138-139 disorder
       Region 1mzf A 140-349 order
 Evidence X-RAY 1yci A Reference
       Region 1yci A 1-13 disorder
       Region 1yci A 14-349 order
 Evidence X-RAY 2w0x A Reference
       Region 2w0x A 1-7 disorder
       Region 2w0x A 8-349 order
 Evidence X-RAY 2yc0 A Reference
       Region 2yc0 A 1-349 order
 Evidence X-RAY 2yde A Reference
       Region 2yde A 1-349 order
 Evidence X-RAY 3kcx A Reference
       Region 3kcx A 15-303 order
       Region 3kcx A 304-306 disorder
       Region 3kcx A 307-349 order
 Evidence X-RAY 3kcy A Reference
       Region 3kcy A 15-303 order
       Region 3kcy A 304-306 disorder
       Region 3kcy A 307-349 order
 Evidence X-RAY 3od4 A Reference
       Region 3od4 A 1-7 disorder
       Region 3od4 A 8-349 order
 Evidence X-RAY 4ai8 A Reference
       Region 4ai8 A 1-10 disorder
       Region 4ai8 A 11-349 order
 Evidence X-RAY 4bio A Reference
       Region 4bio A 1-10 disorder
       Region 4bio A 11-349 order
 Evidence X-RAY 4z1v A Reference
       Region 4z1v A 1-8 disorder
       Region 4z1v A 9-349 order
 Evidence X-RAY 4z2w A Reference
       Region 4z2w A 1-8 disorder
       Region 4z2w A 9-349 order
 Evidence X-RAY 5jwk A Reference
       Region 5jwk A 1-8 disorder
       Region 5jwk A 9-349 order
 Evidence X-RAY 5jwl A Reference
       Region 5jwl A 1-8 disorder
       Region 5jwl A 9-349 order
 Evidence X-RAY 5opc A Reference
       Region 5opc A 1-10 disorder
       Region 5opc A 11-349 order
Seq 11-349 Hetero tetramer :
 Evidence X-RAY 3d8c A Reference
       Region 3d8c A 11-349 order
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-30
Order 31-349
ProS 4-8,20-30
AlphaFold
Disorder 1-25,349-349
Order 26-348
SEG 2-10
Function
Function in SwissProt
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Biological Process
See also
Diagram with PDB data
HIF1A/HIF1ANFactor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide