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IID00399
 UniprotQ9UKK6
ProteinNTF2-related export protein 1
GeneNXT1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
140
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-140 Hetero trimer : IID00225Complex
 Evidence X-RAY 1jn5 A Reference
       Region 1jn5 A 1-3 disorder
       Region 1jn5 A 4-139 order
       Region 1jn5 A 140-140 disorder
Seq 1-140 Hetero dimer : IID00225Complex
 Evidence X-RAY 1jkg A Reference
       Region 1jkg A 1-1 disorder
       Region 1jkg A 2-140 order
Seq 2-140 Hetero tetramer : IID00225Complex
 Evidence X-RAY 4wyk B Reference
       Region 4wyk B 2-2 disorder
       Region 4wyk B 3-140 order
 Evidence X-RAY 4wyk D Reference
       Region 4wyk D 2-2 disorder
       Region 4wyk D 3-140 order
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-5
Order 6-83,89-140
AlphaFold
Disorder 1-3,139-140
Order 4-138
Pfam Hmmer
PF02136 16-135 2.3e-39
Function
Function in SwissProt
Stimulator of protein export for NES-containing proteins (PubMed:10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602).