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IID00400
 UniprotQ9UMN6
ProteinHistone-lysine N-methyltransferase 2B
GeneKMT2B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2715
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 955-1020 Monomer :
 Evidence X-RAY 4pzi A Reference
       Region 4pzi A 955-955 disorder
       Region 4pzi A 956-1016 order
       Region 4pzi A 1017-1020 disorder
Seq 2504-2517 Hetero dimer : IID00377Complex
 Evidence X-RAY 4erz E Reference
       Region 4erz E 2504-2515 order
       Region 4erz E 2516-2517 disorder
 Evidence X-RAY 4erz F Reference
       Region 4erz F 2504-2515 order
       Region 4erz F 2516-2517 disorder
 Evidence X-RAY 4erz D Reference
       Region 4erz D 2504-2515 order
       Region 4erz D 2516-2517 disorder
 Evidence X-RAY 3uvm B Reference
       Region 3uvm B 2508-2517 order
Seqphosphorylation
    113-113 Phosphoserine
    114-114 Phosphoserine
    118-118 Phosphoserine
    351-351 Phosphoserine
    821-821 Phosphoserine
    844-844 Phosphoserine
    861-861 Phosphoserine
    936-936 Phosphoserine
    1032-1032 Phosphoserine
    1035-1035 Phosphoserine
    1092-1092 Phosphoserine
    1095-1095 Phosphoserine
    1930-1930 Phosphoserine
    1936-1936 Phosphoserine
    2068-2068 Phosphothreonine
    2083-2083 Phosphothreonine
    2288-2288 Phosphoserine
    2348-2348 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-353,398-1175,1427-1432,1439-1445,1521-1527,1537-1570,1820-2403,2509-2556
Order 354-397,1176-1259,1265-1426,1433-1438,1446-1520,1528-1536,1571-1819,2404-2508,2557-2715
ProS 7-24,41-47,59-84,97-100,790-794,800-811,865-873,881-892,899-904,960-1010,1155-1159,1164-1175,1427-1432,1521-1527,1537-1549,1560-1570,1820-1826,1862-1873,2034-2041,2061-2066,2296-2301,2323-2339,2396-2403,2509-2528,2550-2556
Pfam Hmmer
PF02008 959-1005 1.7e-22
PF00628 1203-1252 7.1e-08
PF00628 1253-1303 3.1e-07
PF00628 1337-1396 2.5e-10
PF05964 1732-1782 1.1e-19
PF05965 2411-2494 1.5e-35
PF00856 2569-2697 9.1e-50
SEG 2-63 ,67-83 ,86-106 ,110-122 ,198-210 ,216-233 ,237-245 ,248-260 ,271-300 ,317-337 ,355-383 ,392-463 ,479-508 ,548-559 ,569-597 ,619-638 ,668-695 ,731-772 ,808-812 ,905-917 ,929-944 ,1034-1057 ,1097-1125 ,1409-1421 ,1496-1501 ,1807-1821 ,1876-1894 ,1907-1932 ,1955-1976 ,1986-1998 ,2014-2032 ,2089-2104 ,2122-2131 ,2210-2268 ,2289-2298 ,2340-2351 ,2362-2378 ,2390-2399
Function
Function in SwissProt
Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.