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IID00400
 UniprotQ9UMN6
ProteinHistone-lysine N-methyltransferase 2B
GeneKMT2B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2715
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 955-1020 Monomer :
 Evidence X-RAY 4pzi A Reference
       Region 4pzi A 955-955 disorder
       Region 4pzi A 956-1016 order
       Region 4pzi A 1017-1020 disorder
Seq 2504-2517 Hetero dimer : IID00377Complex
 Evidence X-RAY 3uvm B Reference
       Region 3uvm B 2508-2517 order
 Evidence X-RAY 4erz D Reference
       Region 4erz D 2504-2515 order
       Region 4erz D 2516-2517 disorder
 Evidence X-RAY 4erz E Reference
       Region 4erz E 2504-2515 order
       Region 4erz E 2516-2517 disorder
 Evidence X-RAY 4erz F Reference
       Region 4erz F 2504-2515 order
       Region 4erz F 2516-2517 disorder
Seqphosphorylation
    113-113 Phosphoserine
    114-114 Phosphoserine
    118-118 Phosphoserine
    351-351 Phosphoserine
    821-821 Phosphoserine
    844-844 Phosphoserine
    861-861 Phosphoserine
    936-936 Phosphoserine
    1032-1032 Phosphoserine
    1035-1035 Phosphoserine
    1092-1092 Phosphoserine
    1095-1095 Phosphoserine
    1930-1930 Phosphoserine
    1936-1936 Phosphoserine
    2068-2068 Phosphothreonine
    2083-2083 Phosphothreonine
    2288-2288 Phosphoserine
    2348-2348 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-353,398-1175,1427-1432,1439-1445,1521-1527,1537-1570,1820-2403,2509-2556
Order 354-397,1176-1259,1265-1426,1433-1438,1446-1520,1528-1536,1571-1819,2404-2508,2557-2715
ProS 7-24,41-47,59-84,97-100,790-794,800-811,865-873,881-892,899-904,960-1010,1155-1159,1164-1175,1427-1432,1521-1527,1537-1549,1560-1570,1820-1826,1862-1873,2034-2041,2061-2066,2296-2301,2323-2339,2396-2403,2509-2528,2550-2556
Pfam Hmmer
PF02008 959-1005 1.7e-22
PF00628 1203-1252 7.1e-08
PF00628 1253-1303 3.1e-07
PF00628 1337-1396 2.5e-10
PF05964 1732-1782 1.1e-19
PF05965 2411-2494 1.5e-35
PF00856 2569-2697 9.1e-50
SEG 2-63 ,67-83 ,86-106 ,110-122 ,198-210 ,216-233 ,237-245 ,248-260 ,271-300 ,317-337 ,355-383 ,392-463 ,479-508 ,548-559 ,569-597 ,619-638 ,668-695 ,731-772 ,808-812 ,905-917 ,929-944 ,1034-1057 ,1097-1125 ,1409-1421 ,1496-1501 ,1807-1821 ,1876-1894 ,1907-1932 ,1955-1976 ,1986-1998 ,2014-2032 ,2089-2104 ,2122-2131 ,2210-2268 ,2289-2298 ,2340-2351 ,2362-2378 ,2390-2399
Function
Function in SwissProt
Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:17707229). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:17707229). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity).