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IID00401
 UniprotQ9UNN5
ProteinFAS-associated factor 1
GeneFAF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
650
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 5-47 Monomer :
 Evidence X-RAY 3e21 A Reference
       Region 3e21 A 5-44 order
       Region 3e21 A 45-47 disorder
Seq 99-191 Monomer :
 Evidence NMR 2dzm A Reference
       Region 2dzm A 99-191 order
       Region 2dzm A 179-191 high_rmsd
Seq 325-495 Monomer :
 Evidence NMR 2ec4 A Reference
       Region 2ec4 A 325-495 order
       Region 2ec4 A 325-328 high_rmsd
       Region 2ec4 A 493-495 high_rmsd
Seqdisorder 551-568
 Evidence NMR Reference
       Region 551-568 disorder
Seq 568-650 Hetero dimer : IID00201Complex
 Evidence X-RAY 3qc8 B Reference
       Region 3qc8 B 571-650 order
 Evidence X-RAY 3qq8 B Reference
       Region 3qq8 B 568-569 disorder
       Region 3qq8 B 570-649 order
       Region 3qq8 B 650-650 disorder
 Evidence X-RAY 3qwz B Reference
       Region 3qwz B 571-650 order
Seq 568-650 Monomer :
 Evidence NMR 1h8c A Reference
       Region 1h8c A 569-650 order
       Region 1h8c A 569-570 high_rmsd
 Evidence X-RAY 3qca A Reference
       Region 3qca A 571-650 order
 Evidence X-RAY 3qca B Reference
       Region 3qca B 571-650 order
 Evidence X-RAY 3qca C Reference
       Region 3qca C 571-650 order
 Evidence X-RAY 3qca D Reference
       Region 3qca D 571-650 order
 Evidence X-RAY 3qx1 A Reference
       Region 3qx1 A 571-650 order
 Evidence X-RAY 3qx1 B Reference
       Region 3qx1 B 571-649 order
       Region 3qx1 B 650-650 disorder
 Evidence X-RAY 3r3m A Reference
       Region 3r3m A 568-649 order
       Region 3r3m A 650-650 disorder
 Evidence X-RAY 3r3m B Reference
       Region 3r3m B 568-649 order
       Region 3r3m B 650-650 disorder
 Evidence X-RAY 3r3m C Reference
       Region 3r3m C 568-568 disorder
       Region 3r3m C 569-649 order
       Region 3r3m C 650-650 disorder
 Evidence X-RAY 3r3m D Reference
       Region 3r3m D 568-649 order
       Region 3r3m D 650-650 disorder
Seqphosphorylation
    582-582 Phosphoserine
    580-580 Phosphothreonine
    320-320 Phosphoserine
 
Prediction
NeProc
Disorder 1-6,49-97,267-306,447-460,528-545
Order 7-48,98-266,307-446,461-527,546-563,570-650
ProS 295-306,447-455,528-545
AlphaFold
Disorder 1-3,5-5,46-98,146-149,172-189,269-320,325-327,567-570
Order 4-4,6-45,99-145,150-171,190-268,321-324,328-566,571-650
Pfam Hmmer
PF00789 568-648 2.8e-32
SEG 68-83 ,175-181 ,538-555
Function
Function in SwissProt
Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity).