Search Keyword:


Search option:


IID00404
 UniprotO00255
ProteinMenin
GeneMEN1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
615
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-53,74-148,154-391,404-432,537-593 Monomer :
 Evidence X-RAY 4x5y A Reference
       Region 4x5y A 1-1 disorder
       Region 4x5y A 2-53 order
       Region 4x5y A 74-148 order
       Region 4x5y A 154-391 order
       Region 4x5y A 404-432 order
       Region 4x5y A 537-541 order
       Region 4x5y A 542-553 disorder
       Region 4x5y A 554-593 order
Seq 1-53,74-148,154-391,404-432,537-598 Monomer :
 Evidence X-RAY 4x5z A Reference
       Region 4x5z A 1-1 disorder
       Region 4x5z A 2-53 order
       Region 4x5z A 74-148 order
       Region 4x5z A 154-391 order
       Region 4x5z A 404-432 order
       Region 4x5z A 537-541 order
       Region 4x5z A 542-553 disorder
       Region 4x5z A 554-593 order
       Region 4x5z A 594-598 disorder
Seq 1-148,154-464,525-615 Hetero dimer : IID00379Complex
 Evidence X-RAY 3u85 A Reference
       Region 3u85 A 2-148 order
       Region 3u85 A 154-390 order
       Region 3u85 A 391-406 disorder
       Region 3u85 A 407-464 order
       Region 3u85 A 525-532 order
       Region 3u85 A 533-552 disorder
       Region 3u85 A 553-586 order
       Region 3u85 A 587-615 disorder
 Evidence X-RAY 4gq6 A Reference
       Region 4gq6 A 1-1 disorder
       Region 4gq6 A 2-53 order
       Region 4gq6 A 74-148 order
       Region 4gq6 A 154-391 order
       Region 4gq6 A 404-464 order
       Region 4gq6 A 542-542 order
       Region 4gq6 A 543-553 disorder
       Region 4gq6 A 554-593 order
       Region 4gq6 A 594-598 disorder
Seq 1-148,154-464,525-615 Monomer :
 Evidence X-RAY 3u84 B Reference
       Region 3u84 B 2-70 order
       Region 3u84 B 71-74 disorder
       Region 3u84 B 75-148 order
       Region 3u84 B 154-204 order
       Region 3u84 B 205-210 disorder
       Region 3u84 B 211-390 order
       Region 3u84 B 391-406 disorder
       Region 3u84 B 407-464 order
       Region 3u84 B 525-527 disorder
       Region 3u84 B 528-533 order
       Region 3u84 B 528-533 order
       Region 3u84 B 534-552 disorder
       Region 3u84 B 553-586 order
       Region 3u84 B 587-615 disorder
 Evidence X-RAY 3u84 A Reference
       Region 3u84 A 2-148 order
       Region 3u84 A 154-391 order
       Region 3u84 A 392-406 disorder
       Region 3u84 A 407-464 order
       Region 3u84 A 525-533 order
       Region 3u84 A 534-538 disorder
       Region 3u84 A 539-544 order
       Region 3u84 A 545-552 disorder
       Region 3u84 A 553-586 order
       Region 3u84 A 587-600 disorder
       Region 3u84 A 601-613 order
       Region 3u84 A 614-615 disorder
 Evidence X-RAY 4og8 A Reference
       Region 4og8 A 1-1 disorder
       Region 4og8 A 2-53 order
       Region 4og8 A 74-148 order
       Region 4og8 A 154-391 order
       Region 4og8 A 404-464 order
       Region 4og8 A 542-543 order
       Region 4og8 A 544-552 disorder
       Region 4og8 A 553-593 order
       Region 4og8 A 594-598 disorder
 Evidence X-RAY 4og7 A Reference
       Region 4og7 A 1-1 disorder
       Region 4og7 A 2-53 order
       Region 4og7 A 74-148 order
       Region 4og7 A 154-391 order
       Region 4og7 A 404-464 order
       Region 4og7 A 542-543 order
       Region 4og7 A 544-552 disorder
       Region 4og7 A 553-592 order
       Region 4og7 A 593-598 disorder
 Evidence X-RAY 4og6 A Reference
       Region 4og6 A 1-1 disorder
       Region 4og6 A 2-53 order
       Region 4og6 A 74-148 order
       Region 4og6 A 154-391 order
       Region 4og6 A 404-464 order
       Region 4og6 A 542-543 order
       Region 4og6 A 544-553 disorder
       Region 4og6 A 554-593 order
       Region 4og6 A 594-598 disorder
 Evidence X-RAY 4og5 A Reference
       Region 4og5 A 1-1 disorder
       Region 4og5 A 2-53 order
       Region 4og5 A 74-148 order
       Region 4og5 A 154-391 order
       Region 4og5 A 404-464 order
       Region 4og5 A 542-544 order
       Region 4og5 A 554-593 order
       Region 4og5 A 594-598 disorder
 Evidence X-RAY 4og4 A Reference
       Region 4og4 A 1-1 disorder
       Region 4og4 A 2-53 order
       Region 4og4 A 74-148 order
       Region 4og4 A 154-391 order
       Region 4og4 A 404-464 order
       Region 4og4 A 542-544 order
       Region 4og4 A 554-593 order
       Region 4og4 A 594-598 disorder
 Evidence X-RAY 4og3 A Reference
       Region 4og3 A 1-1 disorder
       Region 4og3 A 2-53 order
       Region 4og3 A 74-148 order
       Region 4og3 A 154-391 order
       Region 4og3 A 404-464 order
       Region 4og3 A 542-543 order
       Region 4og3 A 544-544 disorder
       Region 4og3 A 554-591 order
       Region 4og3 A 592-598 disorder
 Evidence X-RAY 4gq4 A Reference
       Region 4gq4 A 1-1 disorder
       Region 4gq4 A 2-53 order
       Region 4gq4 A 74-148 order
       Region 4gq4 A 154-391 order
       Region 4gq4 A 404-464 order
       Region 4gq4 A 542-543 order
       Region 4gq4 A 544-553 disorder
       Region 4gq4 A 554-593 order
       Region 4gq4 A 594-598 disorder
 Evidence X-RAY 4gq3 A Reference
       Region 4gq3 A 1-1 disorder
       Region 4gq3 A 2-53 order
       Region 4gq3 A 74-148 order
       Region 4gq3 A 154-391 order
       Region 4gq3 A 404-464 order
       Region 4gq3 A 542-553 disorder
       Region 4gq3 A 554-593 order
       Region 4gq3 A 594-598 disorder
 Evidence X-RAY 4gpq A Reference
       Region 4gpq A 1-1 disorder
       Region 4gpq A 2-53 order
       Region 4gpq A 74-148 order
       Region 4gpq A 154-391 order
       Region 4gpq A 404-464 order
       Region 4gpq A 542-553 disorder
       Region 4gpq A 554-594 order
       Region 4gpq A 595-598 disorder
 Evidence X-RAY 5ddf A Reference
       Region 5ddf A 1-1 disorder
       Region 5ddf A 2-53 order
       Region 5ddf A 74-148 order
       Region 5ddf A 154-391 order
       Region 5ddf A 404-464 order
       Region 5ddf A 542-553 disorder
       Region 5ddf A 554-591 order
       Region 5ddf A 592-593 disorder
 Evidence X-RAY 5dde A Reference
       Region 5dde A 1-1 disorder
       Region 5dde A 2-53 order
       Region 5dde A 74-148 order
       Region 5dde A 154-391 order
       Region 5dde A 404-464 order
       Region 5dde A 542-553 disorder
       Region 5dde A 554-593 order
 Evidence X-RAY 5ddd A Reference
       Region 5ddd A 1-1 disorder
       Region 5ddd A 2-53 order
       Region 5ddd A 74-148 order
       Region 5ddd A 154-391 order
       Region 5ddd A 404-464 order
       Region 5ddd A 542-553 disorder
       Region 5ddd A 554-593 order
 Evidence X-RAY 5ddc A Reference
       Region 5ddc A 1-2 disorder
       Region 5ddc A 3-53 order
       Region 5ddc A 74-148 order
       Region 5ddc A 154-391 order
       Region 5ddc A 404-464 order
       Region 5ddc A 542-553 disorder
       Region 5ddc A 554-593 order
       Region 5ddc A 594-598 disorder
 Evidence X-RAY 5ddb A Reference
       Region 5ddb A 1-2 disorder
       Region 5ddb A 3-53 order
       Region 5ddb A 74-148 order
       Region 5ddb A 154-391 order
       Region 5ddb A 404-464 order
       Region 5ddb A 542-553 disorder
       Region 5ddb A 554-591 order
       Region 5ddb A 592-598 disorder
 Evidence X-RAY 5dda A Reference
       Region 5dda A 1-1 disorder
       Region 5dda A 2-53 order
       Region 5dda A 74-148 order
       Region 5dda A 154-391 order
       Region 5dda A 404-464 order
       Region 5dda A 542-553 disorder
       Region 5dda A 554-592 order
       Region 5dda A 593-593 disorder
 Evidence X-RAY 5dd9 A Reference
       Region 5dd9 A 1-1 disorder
       Region 5dd9 A 2-53 order
       Region 5dd9 A 74-148 order
       Region 5dd9 A 154-391 order
       Region 5dd9 A 404-464 order
       Region 5dd9 A 542-553 disorder
       Region 5dd9 A 554-593 order
       Region 5dd9 A 594-598 disorder
 Evidence X-RAY 5db3 A Reference
       Region 5db3 A 1-1 disorder
       Region 5db3 A 2-53 order
       Region 5db3 A 74-148 order
       Region 5db3 A 154-391 order
       Region 5db3 A 404-464 order
       Region 5db3 A 542-553 disorder
       Region 5db3 A 554-593 order
 Evidence X-RAY 5db2 A Reference
       Region 5db2 A 1-1 disorder
       Region 5db2 A 2-53 order
       Region 5db2 A 74-148 order
       Region 5db2 A 154-391 order
       Region 5db2 A 404-464 order
       Region 5db2 A 542-553 disorder
       Region 5db2 A 554-593 order
 Evidence X-RAY 5db1 A Reference
       Region 5db1 A 1-1 disorder
       Region 5db1 A 2-53 order
       Region 5db1 A 74-148 order
       Region 5db1 A 154-391 order
       Region 5db1 A 404-464 order
       Region 5db1 A 542-553 disorder
       Region 5db1 A 554-593 order
 Evidence X-RAY 5db0 A Reference
       Region 5db0 A 1-1 disorder
       Region 5db0 A 2-53 order
       Region 5db0 A 74-148 order
       Region 5db0 A 154-391 order
       Region 5db0 A 404-464 order
       Region 5db0 A 542-553 disorder
       Region 5db0 A 554-593 order
 Evidence X-RAY 6b41 A Reference
       Region 6b41 A 2-70 order
       Region 6b41 A 71-73 disorder
       Region 6b41 A 74-148 order
       Region 6b41 A 154-390 order
       Region 6b41 A 391-406 disorder
       Region 6b41 A 407-464 order
       Region 6b41 A 525-532 order
       Region 6b41 A 533-552 disorder
       Region 6b41 A 553-586 order
       Region 6b41 A 587-615 disorder
Seq 2-148,154-464,525-615 Homo dimer :
 Evidence X-RAY 4i80 A Reference
       Region 4i80 A 2-148 order
       Region 4i80 A 154-390 order
       Region 4i80 A 391-406 disorder
       Region 4i80 A 407-464 order
       Region 4i80 A 525-532 order
       Region 4i80 A 533-552 disorder
       Region 4i80 A 553-586 order
       Region 4i80 A 587-615 disorder
Seq 2-148,154-464,525-615 Hetero trimer : IID00379Complex,IID00408Complex
 Evidence X-RAY 3u88 B Reference
       Region 3u88 B 2-148 order
       Region 3u88 B 154-391 order
       Region 3u88 B 392-404 disorder
       Region 3u88 B 405-464 order
       Region 3u88 B 525-525 order
       Region 3u88 B 526-548 disorder
       Region 3u88 B 549-587 order
       Region 3u88 B 588-615 disorder
 Evidence X-RAY 3u88 A Reference
       Region 3u88 A 2-70 order
       Region 3u88 A 71-72 disorder
       Region 3u88 A 73-148 order
       Region 3u88 A 154-390 order
       Region 3u88 A 391-406 disorder
       Region 3u88 A 407-464 order
       Region 3u88 A 525-551 disorder
       Region 3u88 A 552-588 order
       Region 3u88 A 589-615 disorder
Seq 2-148,154-464,525-615 Hetero dimer : IID00542Complex
 Evidence X-RAY 3u86 A Reference
       Region 3u86 A 2-148 order
       Region 3u86 A 154-390 order
       Region 3u86 A 391-406 disorder
       Region 3u86 A 407-464 order
       Region 3u86 A 525-532 order
       Region 3u86 A 533-552 disorder
       Region 3u86 A 553-586 order
       Region 3u86 A 587-615 disorder
Seqphosphorylation
    594-594 Phosphothreonine
    543-543 Phosphoserine
    487-487 Phosphoserine
 
Prediction
NeProc
Disorder 58-72,379-401,462-547,554-564,574-610
Order 1-53,73-378,402-461,548-553,565-573
ProS 67-72,393-396,472-486,554-564,574-610
AlphaFold
Disorder 1-1,150-154,392-405,465-551,587-615
Order 2-149,155-391,406-464,552-586
SEG 254-270 ,391-402 ,460-499 ,535-549 ,582-593
Function
Function in SwissProt
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.