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IID00407
 UniprotO60566
ProteinMitotic checkpoint serine/threonine-protein kinase BUB1 beta
GeneBUB1B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1050
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 20-42 Hetero dimer : Q12834
 Evidence X-RAY 4ggd D Reference
       Region 4ggd D 20-22 disorder
       Region 4ggd D 23-30 order
       Region 4ggd D 31-42 disorder
 Evidence X-RAY 4ggd C Reference
       Region 4ggd C 20-23 disorder
       Region 4ggd C 24-30 order
       Region 4ggd C 31-42 disorder
Seq 57-220 Hetero dimer : IID00417Complex
 Evidence X-RAY 3si5 B Reference
       Region 3si5 B 57-203 order
       Region 3si5 B 204-220 disorder
 Evidence X-RAY 3si5 A Reference
       Region 3si5 A 57-205 order
       Region 3si5 A 206-220 disorder
Seq 57-220 Monomer :
 Evidence X-RAY 2wvi A Reference
       Region 2wvi A 57-91 order
       Region 2wvi A 92-95 disorder
       Region 2wvi A 96-220 order
Seq 647-720 Hetero dimer : Q13362
 Evidence X-RAY 5swf B Reference
       Region 5swf B 668-676 order
 Evidence X-RAY 5k6s B Reference
       Region 5k6s B 663-666 disorder
       Region 5k6s B 667-677 order
       Region 5k6s B 678-681 disorder
 Evidence X-RAY 5jja D Reference
       Region 5jja D 647-667 disorder
       Region 5jja D 668-675 order
       Region 5jja D 676-720 disorder
 Evidence X-RAY 5jja C Reference
       Region 5jja C 647-667 disorder
       Region 5jja C 668-675 order
       Region 5jja C 676-720 disorder
Seqphosphorylation
    1042-1042 Phosphothreonine
    1008-1008 Phosphothreonine; by PLK1
    792-792 Phosphothreonine; by PLK1
    697-697 Phosphoserine
    676-676 Phosphoserine; by PLK1
    670-670 Phosphoserine
    665-665 Phosphoserine
    435-435 Phosphoserine
    543-543 Phosphoserine
    367-367 Phosphoserine
    1043-1043 Phosphoserine
Seqacetylation
    250-250 N6-acetyllysine; by PCAF
 
Prediction
NeProc
Disorder 1-35,45-52,214-395,418-420,470-707
Order 36-44,53-213,396-417,421-469,708-1050
ProS 16-35,266-278,291-324,333-347,360-395,418-420,477-521,526-533,540-565,574-626,635-647,654-682,695-707
AlphaFold
Disorder 1-21,24-25,44-53,91-95,211-271,279-396,399-399,405-408,460-719,735-735,738-739,816-822,837-841,892-905,922-926,928-928,937-940,942-944,1041-1050
Order 22-23,26-43,54-90,96-210,272-278,397-398,400-404,409-459,720-734,736-737,740-815,823-836,842-891,906-921,927-927,929-936,941-941,945-1040
Pfam Hmmer
PF08311 55-179 4.8e-72
SEG 209-218 ,390-402 ,441-457 ,682-697
Function
Function in SwissProt
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.