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IID00408
 UniprotO75475
ProteinPC4 and SFRS1-interacting protein
GenePSIP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
530
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-135 Monomer :
 Evidence X-RAY 4fu6 A Reference
       Region 4fu6 A 1-30 order
       Region 4fu6 A 31-32 disorder
       Region 4fu6 A 33-91 order
       Region 4fu6 A 92-135 disorder
 Evidence NMR 3zeh A Reference
       Region 3zeh A 3-93 order
       Region 3zeh A 92-93 high_rmsd
       Region 3zeh A 94-100 disorder
 Evidence NMR 2m16 A Reference
       Region 2m16 A 1-93 order
Seq 337-442 Monomer : IID00379Complex
 Evidence NMR 2mtn A Reference
       Region 2mtn A 337-344 disorder
       Region 2mtn A 345-436 order
       Region 2mtn A 346-346 high_rmsd
       Region 2mtn A 432-436 high_rmsd
       Region 2mtn A 437-442 disorder
Seq 344-426 Hetero dimer : IID00379Complex
 Evidence NMR 2msr B Reference
       Region 2msr B 344-426 order
       Region 2msr B 344-345 high_rmsd
Seq 345-431 Homo octamer :
 Evidence X-RAY 5oym H Reference
       Region 5oym H 345-429 order
       Region 5oym H 430-431 disorder
 Evidence X-RAY 5oym G Reference
       Region 5oym G 345-431 order
 Evidence X-RAY 5oym F Reference
       Region 5oym F 345-430 order
       Region 5oym F 431-431 disorder
 Evidence X-RAY 5oym E Reference
       Region 5oym E 345-430 order
       Region 5oym E 431-431 disorder
 Evidence X-RAY 5oym D Reference
       Region 5oym D 345-430 order
       Region 5oym D 431-431 disorder
 Evidence X-RAY 5oym C Reference
       Region 5oym C 345-429 order
       Region 5oym C 430-431 disorder
 Evidence X-RAY 5oym B Reference
       Region 5oym B 345-427 order
       Region 5oym B 428-431 disorder
 Evidence X-RAY 5oym A Reference
       Region 5oym A 345-429 order
       Region 5oym A 430-431 disorder
Seq 347-424 Hetero dimer :
 Evidence X-RAY 5n88 E Reference
       Region 5n88 E 347-424 order
Seq 347-425 Hetero dimer :
 Evidence X-RAY 5n88 D Reference
       Region 5n88 D 347-425 order
Seq 347-435 Hetero octamer : P35956
 Evidence X-RAY 3hpg L Reference
       Region 3hpg L 347-347 disorder
       Region 3hpg L 348-379 order
       Region 3hpg L 380-384 disorder
       Region 3hpg L 385-413 order
       Region 3hpg L 414-435 disorder
 Evidence X-RAY 3hpg K Reference
       Region 3hpg K 347-381 order
       Region 3hpg K 382-394 disorder
       Region 3hpg K 395-426 order
       Region 3hpg K 427-435 disorder
 Evidence X-RAY 3hpg J Reference
       Region 3hpg J 347-423 order
       Region 3hpg J 424-435 disorder
 Evidence X-RAY 3hpg I Reference
       Region 3hpg I 347-347 disorder
       Region 3hpg I 348-382 order
       Region 3hpg I 383-385 disorder
       Region 3hpg I 386-418 order
       Region 3hpg I 419-435 disorder
Seq 347-435 Hetero trimer : IID00379Complex,IID00404Complex
 Evidence X-RAY 3u88 D Reference
       Region 3u88 D 347-352 disorder
       Region 3u88 D 353-363 order
       Region 3u88 D 364-369 disorder
       Region 3u88 D 370-404 order
       Region 3u88 D 405-409 disorder
       Region 3u88 D 410-430 order
       Region 3u88 D 431-435 disorder
 Evidence X-RAY 3u88 C Reference
       Region 3u88 C 347-347 disorder
       Region 3u88 C 348-429 order
       Region 3u88 C 430-435 disorder
Seq 347-435 Hetero trimer : P04584
 Evidence X-RAY 3f9k i Reference
       Region 3f9k i 347-435 order
 Evidence X-RAY 3f9k e Reference
       Region 3f9k e 347-435 order
 Evidence X-RAY 3f9k a Reference
       Region 3f9k a 347-435 order
 Evidence X-RAY 3f9k W Reference
       Region 3f9k W 347-435 order
 Evidence X-RAY 3f9k S Reference
       Region 3f9k S 347-435 order
 Evidence X-RAY 3f9k O Reference
       Region 3f9k O 347-435 order
 Evidence X-RAY 3f9k K Reference
       Region 3f9k K 347-435 order
 Evidence X-RAY 3f9k G Reference
       Region 3f9k G 347-435 order
 Evidence X-RAY 3f9k u Reference
       Region 3f9k u 347-435 order
 Evidence X-RAY 3f9k q Reference
       Region 3f9k q 347-435 order
 Evidence X-RAY 3f9k m Reference
       Region 3f9k m 347-435 order
 Evidence X-RAY 3f9k C Reference
       Region 3f9k C 347-435 order
Seq 347-435 Hetero octamer : P35956
 Evidence X-RAY 3hpg J Reference
       Region 3hpg J 347-423 order
       Region 3hpg J 424-435 disorder
 Evidence X-RAY 3hpg I Reference
       Region 3hpg I 347-347 disorder
       Region 3hpg I 348-382 order
       Region 3hpg I 383-385 disorder
       Region 3hpg I 386-418 order
       Region 3hpg I 419-435 disorder
 Evidence X-RAY 3hpg H Reference
       Region 3hpg H 347-380 order
       Region 3hpg H 381-384 disorder
       Region 3hpg H 385-418 order
       Region 3hpg H 419-435 disorder
 Evidence X-RAY 3hpg G Reference
       Region 3hpg G 347-347 disorder
       Region 3hpg G 348-380 order
       Region 3hpg G 381-383 disorder
       Region 3hpg G 384-423 order
       Region 3hpg G 424-435 disorder
 Evidence X-RAY 3hpg L Reference
       Region 3hpg L 347-347 disorder
       Region 3hpg L 348-379 order
       Region 3hpg L 380-384 disorder
       Region 3hpg L 385-413 order
       Region 3hpg L 414-435 disorder
 Evidence X-RAY 3hpg K Reference
       Region 3hpg K 347-381 order
       Region 3hpg K 382-394 disorder
       Region 3hpg K 395-426 order
       Region 3hpg K 427-435 disorder
 Evidence X-RAY 3hpg H Reference
       Region 3hpg H 347-380 order
       Region 3hpg H 381-384 disorder
       Region 3hpg H 385-418 order
       Region 3hpg H 419-435 disorder
 Evidence X-RAY 3hpg G Reference
       Region 3hpg G 347-347 disorder
       Region 3hpg G 348-380 order
       Region 3hpg G 381-383 disorder
       Region 3hpg G 384-423 order
       Region 3hpg G 424-435 disorder
Seq 347-442 Hetero tetramer : P12497
 Evidence X-RAY 2b4j D Reference
       Region 2b4j D 347-426 order
       Region 2b4j D 427-442 disorder
 Evidence X-RAY 2b4j C Reference
       Region 2b4j C 347-426 order
       Region 2b4j C 427-442 disorder
Seq 347-471 Monomer :
 Evidence NMR 1z9e A Reference
       Region 1z9e A 347-429 order
       Region 1z9e A 430-471 disorder
Seq 348-426 Hetero dimer : Q7Z3K3
 Evidence NMR 2n3a B Reference
       Region 2n3a B 348-426 order
       Region 2n3a B 426-426 high_rmsd
Seq 348-435 Hetero octamer : P35956
 Evidence X-RAY 3hph H Reference
       Region 3hph H 348-431 order
       Region 3hph H 432-433 disorder
       Region 3hph H 434-435 order
 Evidence X-RAY 3hph G Reference
       Region 3hph G 348-352 disorder
       Region 3hph G 353-381 order
       Region 3hph G 382-395 disorder
       Region 3hph G 396-420 order
       Region 3hph G 421-435 disorder
 Evidence X-RAY 3hph F Reference
       Region 3hph F 348-351 disorder
       Region 3hph F 352-380 order
       Region 3hph F 381-395 disorder
       Region 3hph F 396-426 order
       Region 3hph F 427-435 disorder
 Evidence X-RAY 3hph E Reference
       Region 3hph E 348-429 order
       Region 3hph E 430-433 disorder
       Region 3hph E 434-435 order
Seqphosphorylation
    102-102 Phosphoserine
    105-105 Phosphoserine
    106-106 Phosphoserine
    115-115 Phosphothreonine
    122-122 Phosphothreonine
    129-129 Phosphoserine
    141-141 Phosphothreonine
    167-167 Phosphothreonine
    177-177 Phosphoserine
    206-206 Phosphoserine
    271-271 Phosphoserine
    527-527 Phosphothreonine
    522-522 Phosphoserine
    514-514 Phosphoserine
    443-443 Phosphoserine
    437-437 Phosphothreonine
    434-434 Phosphoserine
    275-275 Phosphoserine
    273-273 Phosphoserine
    272-272 Phosphothreonine
 
Prediction
NeProc
Disorder 85-299,328-347,435-530
Order 1-84,300-327,348-429
ProS 85-94,242-258,285-289,336-347,435-451
AlphaFold
Disorder 1-2,30-36,93-314,316-345,430-435,455-530
Order 3-29,37-92,315-315,346-429,436-454
Pfam Hmmer
PF00855 4-76 2.5e-31
SEG 105-122 ,143-155 ,157-170 ,213-258 ,267-291 ,329-345
Function
Function in SwissProt
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.