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IID00409
 UniprotO75496
ProteinGeminin
GeneGMNN
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
209
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-209 Hetero hexamer : Q9H211
 Evidence X-RAY 2wvr B Reference
       Region 2wvr B 1-85 disorder
       Region 2wvr B 86-159 order
       Region 2wvr B 160-209 disorder
 Evidence X-RAY 2wvr A Reference
       Region 2wvr A 1-90 disorder
       Region 2wvr A 91-160 order
       Region 2wvr A 161-209 disorder
Seq 70-152 Homo dimer :
 Evidence X-RAY 1uii B Reference
       Region 1uii B 70-91 disorder
       Region 1uii B 92-152 order
 Evidence X-RAY 1uii A Reference
       Region 1uii A 70-91 disorder
       Region 1uii A 92-152 order
Seq 83-160 Hetero dimer : D6RGH6
 Evidence X-RAY 4bry A Reference
       Region 4bry A 83-91 disorder
       Region 4bry A 92-160 order
Seq 109-145 Homo dimer :
 Evidence X-RAY 1t6f B Reference
       Region 1t6f B 109-145 order
 Evidence X-RAY 1t6f A Reference
       Region 1t6f A 109-145 order
Seq 171-190 Hetero dimer : IID00448Complex
 Evidence NMR 2lp0 B Reference
       Region 2lp0 B 171-190 order
SeqProS verified 171-190 Hetero dimer : IID00448Complex
       Region 2lp0 B 171-190 order
       Region 2wvr A 161-209 disorder
Seqphosphorylation
    34-34 Phosphoserine
    36-36 Phosphoserine
    49-49 Phosphoserine
    63-63 Phosphoserine
    64-64 Phosphoserine
    184-184 Phosphoserine; by CK2
Seqacetylation
    27-27 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-94,162-209
Order 95-161
ProS 12-18,23-43,50-57,82-89,162-172,202-209
AlphaFold
Disorder 1-20,33-34,40-40,42-80,162-208
Order 21-32,35-39,41-41,81-161,209-209
Pfam Hmmer
PF07412 1-190 1.8e-131
SEG 6-18
Function
Function in SwissProt
Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:9635433, PubMed:14993212, PubMed:20129055, PubMed:24064211). It is degraded during the mitotic phase of the cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398).