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IID00410
 UniprotP04271
ProteinProtein S100-B
GeneS100B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
92
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-92 Hetero trimer : IID00726Complex
 Evidence X-RAY 5csi B Reference
       Region 5csi B 1-89 order
       Region 5csi B 90-92 disorder
 Evidence X-RAY 5csi A Reference
       Region 5csi A 1-90 order
       Region 5csi A 91-92 disorder
 Evidence X-RAY 5csf B Reference
       Region 5csf B 1-89 order
       Region 5csf B 90-92 disorder
 Evidence X-RAY 5csf A Reference
       Region 5csf A 1-89 order
       Region 5csf A 90-92 disorder
Seq 1-92 Hetero trimer : IID00726Complex
 Evidence X-RAY 5csn B Reference
       Region 5csn B 1-89 order
       Region 5csn B 90-92 disorder
 Evidence X-RAY 5csn A Reference
       Region 5csn A 1-91 order
       Region 5csn A 92-92 disorder
Seq 1-92 Homo octamer :
 Evidence X-RAY 2h61 H Reference
       Region 2h61 H 1-90 order
       Region 2h61 H 91-92 disorder
 Evidence X-RAY 2h61 G Reference
       Region 2h61 G 1-91 order
       Region 2h61 G 92-92 disorder
 Evidence X-RAY 2h61 F Reference
       Region 2h61 F 1-91 order
       Region 2h61 F 92-92 disorder
 Evidence X-RAY 2h61 E Reference
       Region 2h61 E 1-91 order
       Region 2h61 E 92-92 disorder
 Evidence X-RAY 2h61 D Reference
       Region 2h61 D 1-91 order
       Region 2h61 D 92-92 disorder
 Evidence X-RAY 2h61 C Reference
       Region 2h61 C 1-91 order
       Region 2h61 C 92-92 disorder
 Evidence X-RAY 2h61 B Reference
       Region 2h61 B 1-92 order
 Evidence X-RAY 2h61 A Reference
       Region 2h61 A 1-91 order
       Region 2h61 A 92-92 disorder
Seq 1-92 Hetero trimer : Q15109
 Evidence X-RAY 4xyn B Reference
       Region 4xyn B 1-91 order
       Region 4xyn B 92-92 disorder
 Evidence X-RAY 4xyn A Reference
       Region 4xyn A 1-90 order
       Region 4xyn A 91-92 disorder
Seq 1-92 Hetero trimer : IID00726Complex
 Evidence X-RAY 5csj B Reference
       Region 5csj B 1-89 order
       Region 5csj B 90-92 disorder
 Evidence X-RAY 5csj A Reference
       Region 5csj A 1-90 order
       Region 5csj A 91-92 disorder
Seq 1-92 Homo dimer :
 Evidence NMR 1uwo B Reference
       Region 1uwo B 2-92 order
 Evidence NMR 1uwo A Reference
       Region 1uwo A 2-92 order
 Evidence NMR 2pru B Reference
       Region 2pru B 2-22 order
       Region 2pru B 21-25 high_rmsd
       Region 2pru B 23-25 disorder
       Region 2pru B 26-92 order
       Region 2pru B 46-46 high_rmsd
       Region 2pru B 86-87 high_rmsd
 Evidence NMR 2pru A Reference
       Region 2pru A 2-22 order
       Region 2pru A 21-25 high_rmsd
       Region 2pru A 23-25 disorder
       Region 2pru A 26-92 order
       Region 2pru A 86-92 high_rmsd
 Evidence X-RAY 3d10 B Reference
       Region 3d10 B 1-91 order
       Region 3d10 B 92-92 disorder
 Evidence X-RAY 3d10 A Reference
       Region 3d10 A 1-92 order
 Evidence X-RAY 3d0y B Reference
       Region 3d0y B 1-90 order
       Region 3d0y B 91-92 disorder
 Evidence X-RAY 3d0y A Reference
       Region 3d0y A 1-90 order
       Region 3d0y A 91-92 disorder
 Evidence X-RAY 4xyn D Reference
       Region 4xyn D 1-88 order
       Region 4xyn D 89-92 disorder
 Evidence X-RAY 4xyn C Reference
       Region 4xyn C 1-91 order
       Region 4xyn C 92-92 disorder
 Evidence X-RAY 3hcm B Reference
       Region 3hcm B 1-91 order
       Region 3hcm B 92-92 disorder
 Evidence X-RAY 3hcm A Reference
       Region 3hcm A 1-90 order
       Region 3hcm A 91-92 disorder
 Evidence X-RAY 3czt X Reference
       Region 3czt X 1-91 order
       Region 3czt X 92-92 disorder
Seq 1-92 Hetero trimer : Q15109
 Evidence X-RAY 5d7f B Reference
       Region 5d7f B 1-91 order
       Region 5d7f B 92-92 disorder
 Evidence X-RAY 5d7f A Reference
       Region 5d7f A 1-91 order
       Region 5d7f A 92-92 disorder
Seq 2-92 Hetero tetramer : IID00438Complex
 Evidence NMR 2m49 D Reference
       Region 2m49 D 2-92 order
 Evidence NMR 2m49 B Reference
       Region 2m49 B 2-92 order
Seq 2-92 Hetero tetramer : IID00122Complex
 Evidence NMR 1mq1 B Reference
       Region 1mq1 B 2-92 order
       Region 1mq1 B 22-22 high_rmsd
       Region 1mq1 B 44-47 high_rmsd
       Region 1mq1 B 91-92 high_rmsd
 Evidence NMR 1mq1 A Reference
       Region 1mq1 A 2-92 order
       Region 1mq1 A 22-22 high_rmsd
       Region 1mq1 A 44-47 high_rmsd
       Region 1mq1 A 91-92 high_rmsd
SeqProS verified 23-25 Homo octamer :
       Region 2h61 A 1-91 order
       Region 2h61 B 1-92 order
       Region 2h61 C 1-91 order
       Region 2h61 D 1-91 order
       Region 2h61 E 1-91 order
       Region 2h61 F 1-91 order
       Region 2h61 G 1-91 order
       Region 2h61 H 1-90 order
       Region 2pru A 23-25 disorder
SeqProS verified 23-25 Homo dimer :
       Region 3d0y A 1-90 order
       Region 3d0y B 1-90 order
       Region 3czt X 1-91 order
       Region 2pru A 23-25 disorder
Seqacetylation
    2-2 N-acetylserine; alternate
 
Prediction
NeProc
Order 1-92
AlphaFold
Disorder 91-92
Order 1-90
Pfam Hmmer
PF01023 4-47 6.7e-24
PF00036 53-81 0.00018
SEG 27-42
Function
Function in SwissProt
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Biological Process
Diagram with PDB data
S100B/S100BCALCIUM FORM OF HUMAN S100B, NMR, 20 STRUCTURES
See also
Diagram with PDB data
TP53/S100BSOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)
RPS6KA1/S100BS100B-RSK1 crystal structure C