IID00411
Uniprot P13861
Protein cAMP-dependent protein kinase type II-alpha regulatory subunit
Gene PRKAR2A
Organism Homo sapiens
Sequence
LLPS
Network
xml
rdf
Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
404
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 1-45 Hetero trimer : IID00381 Complex
Region 2kyg B 1-3 high_rmsd
Region 2kyg B 45-45 high_rmsd
Region 2kyg A 1-1 high_rmsd
Seq 2-44 Hetero trimer : Q9P0M2
Region 4zp3 K 2-6 disorder
Region 4zp3 J 2-3 disorder
Region 4zp3 I 2-6 disorder
Region 4zp3 H 2-3 disorder
Region 4zp3 G 2-2 disorder
Region 4zp3 F 2-3 disorder
Region 4zp3 E 2-5 disorder
Region 4zp3 D 2-3 disorder
Region 4zp3 C 2-5 disorder
Region 4zp3 B 2-5 disorder
Region 2izx A 4-5 disorder
Region 5xby C 5-5 disorder
Seq 5-44 Hetero dimer : P38507
Region 5xby A 5-5 disorder
Region 5xby A 44-44 disorder
Region 5h78 B 5-5 disorder
Region 5h78 A 5-5 disorder
99-99 Phosphoserine; by PKA
215-215 Phosphothreonine; by PDPK1
Prediction
Order 2-43,107-312,321-404
Disorder 1-3,45-95,109-115,313-322,394-404
Order 4-44,96-108,116-312,323-393
Function
Function in SwissProt
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.