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IID00411
UniprotP13861
ProteincAMP-dependent protein kinase type II-alpha regulatory subunit
GenePRKAR2A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
404
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-45 Hetero trimer : IID00381Complex
 Evidence NMR 2kyg B Reference
       Region 2kyg B 1-45 order
       Region 2kyg B 1-3 high_rmsd
       Region 2kyg B 45-45 high_rmsd
 Evidence NMR 2kyg A Reference
       Region 2kyg A 1-45 order
       Region 2kyg A 1-1 high_rmsd
Seq 2-44 Hetero trimer : Q9P0M2
 Evidence X-RAY 4zp3 L Reference
       Region 4zp3 L 2-44 order
 Evidence X-RAY 4zp3 K Reference
       Region 4zp3 K 2-6 disorder
       Region 4zp3 K 7-44 order
 Evidence X-RAY 4zp3 J Reference
       Region 4zp3 J 2-3 disorder
       Region 4zp3 J 4-44 order
 Evidence X-RAY 4zp3 I Reference
       Region 4zp3 I 2-6 disorder
       Region 4zp3 I 7-44 order
 Evidence X-RAY 4zp3 H Reference
       Region 4zp3 H 2-3 disorder
       Region 4zp3 H 4-44 order
 Evidence X-RAY 4zp3 G Reference
       Region 4zp3 G 2-2 disorder
       Region 4zp3 G 3-44 order
 Evidence X-RAY 4zp3 F Reference
       Region 4zp3 F 2-3 disorder
       Region 4zp3 F 4-44 order
 Evidence X-RAY 4zp3 E Reference
       Region 4zp3 E 2-5 disorder
       Region 4zp3 E 6-44 order
 Evidence X-RAY 4zp3 D Reference
       Region 4zp3 D 2-3 disorder
       Region 4zp3 D 4-44 order
 Evidence X-RAY 4zp3 C Reference
       Region 4zp3 C 2-5 disorder
       Region 4zp3 C 6-44 order
 Evidence X-RAY 4zp3 B Reference
       Region 4zp3 B 2-5 disorder
       Region 4zp3 B 6-44 order
 Evidence X-RAY 4zp3 A Reference
       Region 4zp3 A 2-44 order
Seq 4-44 Hetero trimer :
 Evidence X-RAY 2izx A Reference
       Region 2izx A 4-5 disorder
       Region 2izx A 6-44 order
 Evidence X-RAY 2izx B Reference
       Region 2izx B 4-44 order
Seq 5-44 Homo dimer : P38507
 Evidence X-RAY 5xby D Reference
       Region 5xby D 5-44 order
 Evidence X-RAY 5xby C Reference
       Region 5xby C 5-5 disorder
       Region 5xby C 6-44 order
Seq 5-44 Hetero dimer : P38507
 Evidence X-RAY 5xby A Reference
       Region 5xby A 5-5 disorder
       Region 5xby A 6-43 order
       Region 5xby A 44-44 disorder
 Evidence X-RAY 5xby B Reference
       Region 5xby B 5-44 order
Seq 5-49 Homo dimer :
 Evidence X-RAY 5h78 B Reference
       Region 5h78 B 5-5 disorder
       Region 5h78 B 6-49 order
 Evidence X-RAY 5h78 A Reference
       Region 5h78 A 5-5 disorder
       Region 5h78 A 6-49 order
Seqphosphorylation
    48-48 Phosphoserine
    54-54 Phosphothreonine
    350-350 Phosphoserine
    58-58 Phosphoserine
    99-99 Phosphoserine; by PKA
    80-80 Phosphoserine
    78-78 Phosphoserine
    215-215 Phosphothreonine; by PDPK1
    395-395 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-1,44-106
Order 2-43,107-312,321-404
ProS 44-48,93-106
AlphaFold
Disorder 1-3,45-95,109-115,313-322,394-404
Order 4-44,96-108,116-312,323-393
Pfam Hmmer
PF02197 8-45 3.2e-18
PF00027 157-246 7.1e-18
PF00027 279-376 5.5e-26
SEG 77-92
Function
Function in SwissProt
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.