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IID00413
 UniprotP36897
ProteinTGF-beta receptor type-1
GeneTGFBR1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
503
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 31-115 Hetero hexamer : IID00414Complex,IID00534Complex
 Evidence X-RAY 3kfd L Reference
       Region 3kfd L 31-32 disorder
       Region 3kfd L 33-62 order
       Region 3kfd L 63-64 disorder
       Region 3kfd L 65-90 order
       Region 3kfd L 91-94 disorder
       Region 3kfd L 95-108 order
       Region 3kfd L 109-115 disorder
 Evidence X-RAY 3kfd K Reference
       Region 3kfd K 31-32 disorder
       Region 3kfd K 33-59 order
       Region 3kfd K 60-62 disorder
       Region 3kfd K 63-87 order
       Region 3kfd K 88-95 disorder
       Region 3kfd K 96-109 order
       Region 3kfd K 110-115 disorder
 Evidence X-RAY 3kfd J Reference
       Region 3kfd J 31-32 disorder
       Region 3kfd J 33-62 order
       Region 3kfd J 63-64 disorder
       Region 3kfd J 65-90 order
       Region 3kfd J 91-94 disorder
       Region 3kfd J 95-108 order
       Region 3kfd J 109-115 disorder
 Evidence X-RAY 3kfd I Reference
       Region 3kfd I 31-32 disorder
       Region 3kfd I 33-59 order
       Region 3kfd I 60-62 disorder
       Region 3kfd I 63-87 order
       Region 3kfd I 88-95 disorder
       Region 3kfd I 96-109 order
       Region 3kfd I 110-115 disorder
Seq 31-115 Monomer :
 Evidence NMR 2l5s A Reference
       Region 2l5s A 31-115 order
       Region 2l5s A 92-92 high_rmsd
       Region 2l5s A 112-115 high_rmsd
Seq 33-111 Hetero hexamer : IID00355Complex,IID00414Complex
 Evidence X-RAY 2pjy C Reference
       Region 2pjy C 33-111 order
Seq 162-503 Homo pentamer :
 Evidence X-RAY 3faa E Reference
       Region 3faa E 162-170 disorder
       Region 3faa E 171-500 order
       Region 3faa E 501-503 disorder
 Evidence X-RAY 3faa D Reference
       Region 3faa D 162-170 disorder
       Region 3faa D 171-500 order
       Region 3faa D 501-503 disorder
 Evidence X-RAY 3faa C Reference
       Region 3faa C 162-170 disorder
       Region 3faa C 171-500 order
       Region 3faa C 501-503 disorder
 Evidence X-RAY 3faa B Reference
       Region 3faa B 162-170 disorder
       Region 3faa B 171-320 order
       Region 3faa B 321-324 disorder
       Region 3faa B 325-367 order
       Region 3faa B 368-370 disorder
       Region 3faa B 371-501 order
       Region 3faa B 502-503 disorder
 Evidence X-RAY 3faa A Reference
       Region 3faa A 162-170 disorder
       Region 3faa A 171-367 order
       Region 3faa A 368-369 disorder
       Region 3faa A 370-500 order
       Region 3faa A 501-503 disorder
 Evidence X-RAY 1ias E Reference
       Region 1ias E 162-170 disorder
       Region 1ias E 171-500 order
       Region 1ias E 501-503 disorder
 Evidence X-RAY 1ias D Reference
       Region 1ias D 162-170 disorder
       Region 1ias D 171-500 order
       Region 1ias D 501-503 disorder
 Evidence X-RAY 1ias C Reference
       Region 1ias C 162-170 disorder
       Region 1ias C 171-500 order
       Region 1ias C 501-503 disorder
 Evidence X-RAY 1ias B Reference
       Region 1ias B 162-170 disorder
       Region 1ias B 171-320 order
       Region 1ias B 321-324 disorder
       Region 1ias B 325-367 order
       Region 1ias B 368-370 disorder
       Region 1ias B 371-501 order
       Region 1ias B 502-503 disorder
 Evidence X-RAY 1ias A Reference
       Region 1ias A 162-170 disorder
       Region 1ias A 171-500 order
       Region 1ias A 501-503 disorder
Seq 162-503 Hetero dimer : P62942
 Evidence X-RAY 1b6c H Reference
       Region 1b6c H 162-174 disorder
       Region 1b6c H 175-500 order
       Region 1b6c H 501-503 disorder
 Evidence X-RAY 1b6c F Reference
       Region 1b6c F 162-174 disorder
       Region 1b6c F 175-500 order
       Region 1b6c F 501-503 disorder
 Evidence X-RAY 1b6c D Reference
       Region 1b6c D 162-174 disorder
       Region 1b6c D 175-500 order
       Region 1b6c D 501-503 disorder
 Evidence X-RAY 1b6c B Reference
       Region 1b6c B 162-174 disorder
       Region 1b6c B 175-500 order
       Region 1b6c B 501-503 disorder
Seq 162-503 Monomer :
 Evidence X-RAY 4x2k A Reference
       Region 4x2k A 200-501 order
       Region 4x2k A 502-503 disorder
 Evidence X-RAY 4x2j A Reference
       Region 4x2j A 200-501 order
       Region 4x2j A 502-503 disorder
 Evidence X-RAY 2x7o E Reference
       Region 2x7o E 162-170 disorder
       Region 2x7o E 171-500 order
       Region 2x7o E 501-503 disorder
 Evidence X-RAY 2x7o D Reference
       Region 2x7o D 162-170 disorder
       Region 2x7o D 171-500 order
       Region 2x7o D 501-503 disorder
 Evidence X-RAY 2x7o C Reference
       Region 2x7o C 162-170 disorder
       Region 2x7o C 171-500 order
       Region 2x7o C 501-503 disorder
 Evidence X-RAY 2x7o B Reference
       Region 2x7o B 162-170 disorder
       Region 2x7o B 171-500 order
       Region 2x7o B 501-503 disorder
 Evidence X-RAY 2x7o A Reference
       Region 2x7o A 162-170 disorder
       Region 2x7o A 171-500 order
       Region 2x7o A 501-503 disorder
 Evidence X-RAY 4x2n A Reference
       Region 4x2n A 200-501 order
       Region 4x2n A 502-503 disorder
 Evidence X-RAY 4x2g A Reference
       Region 4x2g A 200-501 order
       Region 4x2g A 502-503 disorder
 Evidence X-RAY 4x2f A Reference
       Region 4x2f A 200-501 order
       Region 4x2f A 502-503 disorder
 Evidence X-RAY 4x0m A Reference
       Region 4x0m A 200-501 order
       Region 4x0m A 502-503 disorder
 Evidence X-RAY 2wou A Reference
       Region 2wou A 200-496 order
       Region 2wou A 497-503 disorder
 Evidence X-RAY 2wot A Reference
       Region 2wot A 200-500 order
       Region 2wot A 501-503 disorder
 Evidence X-RAY 1vjy A Reference
       Region 1vjy A 201-367 order
       Region 1vjy A 368-371 disorder
       Region 1vjy A 372-503 order
 Evidence X-RAY 5usq A Reference
       Region 5usq A 200-498 order
 Evidence X-RAY 3tzm A Reference
       Region 3tzm A 200-369 order
       Region 3tzm A 370-371 disorder
       Region 3tzm A 372-496 order
       Region 3tzm A 497-503 disorder
 Evidence X-RAY 1rw8 A Reference
       Region 1rw8 A 200-500 order
 Evidence X-RAY 1py5 A Reference
       Region 1py5 A 175-199 disorder
       Region 1py5 A 200-500 order
 Evidence X-RAY 3kcf E Reference
       Region 3kcf E 162-170 disorder
       Region 3kcf E 171-500 order
       Region 3kcf E 501-503 disorder
 Evidence X-RAY 3kcf D Reference
       Region 3kcf D 162-170 disorder
       Region 3kcf D 171-500 order
       Region 3kcf D 501-503 disorder
 Evidence X-RAY 3kcf C Reference
       Region 3kcf C 162-170 disorder
       Region 3kcf C 171-500 order
       Region 3kcf C 501-503 disorder
 Evidence X-RAY 3kcf B Reference
       Region 3kcf B 162-170 disorder
       Region 3kcf B 171-320 order
       Region 3kcf B 321-324 disorder
       Region 3kcf B 325-367 order
       Region 3kcf B 368-370 disorder
       Region 3kcf B 371-501 order
       Region 3kcf B 502-503 disorder
 Evidence X-RAY 3kcf A Reference
       Region 3kcf A 162-170 disorder
       Region 3kcf A 171-367 order
       Region 3kcf A 368-369 disorder
       Region 3kcf A 370-500 order
       Region 3kcf A 501-503 disorder
 Evidence X-RAY 3hmm A Reference
       Region 3hmm A 201-368 order
       Region 3hmm A 369-373 disorder
       Region 3hmm A 374-498 order
       Region 3hmm A 499-503 disorder
 Evidence X-RAY 3gxl A Reference
       Region 3gxl A 201-224 order
       Region 3gxl A 225-227 disorder
       Region 3gxl A 228-366 order
       Region 3gxl A 367-371 disorder
       Region 3gxl A 372-416 order
       Region 3gxl A 417-419 disorder
       Region 3gxl A 420-457 order
       Region 3gxl A 458-459 disorder
       Region 3gxl A 460-498 order
       Region 3gxl A 499-503 disorder
 Evidence X-RAY 5fri A Reference
       Region 5fri A 200-498 order
 Evidence X-RAY 5e90 A Reference
       Region 5e90 A 200-499 order
       Region 5e90 A 500-503 disorder
 Evidence X-RAY 5e8z A Reference
       Region 5e8z A 200-499 order
       Region 5e8z A 500-503 disorder
 Evidence X-RAY 5e8x A Reference
       Region 5e8x A 200-503 order
 Evidence X-RAY 5e8w A Reference
       Region 5e8w A 200-501 order
       Region 5e8w A 502-503 disorder
 Evidence X-RAY 5e8u A Reference
       Region 5e8u A 200-502 order
       Region 5e8u A 503-503 disorder
 Evidence X-RAY 5e8t A Reference
       Region 5e8t A 200-499 order
       Region 5e8t A 500-503 disorder
 Evidence X-RAY 5e8s A Reference
       Region 5e8s A 200-498 order
       Region 5e8s A 499-503 disorder
 Evidence X-RAY 6b8y A Reference
       Region 6b8y A 200-501 order
       Region 6b8y A 502-503 disorder
SeqProS verified 175-199 This region is ordered when interacts with another chain of this protein. :
       Region 2x7o A 171-500 order
       Region 2x7o B 171-500 order
       Region 2x7o C 162-170 disorder
       Region 2x7o D 171-500 order
       Region 2x7o E 171-500 order
       Region 3kcf A 171-367 order
       Region 3kcf B 171-320 order
       Region 3kcf C 171-500 order
       Region 3kcf D 171-500 order
       Region 3kcf E 171-500 order
       Region 1py5 A 175-199 disorder
SeqProS verified 175-199 This region is ordered when interacts with another chain of this protein. Homo pentamer :
       Region 1ias A 171-500 order
       Region 1ias B 171-320 order
       Region 1ias C 171-500 order
       Region 1ias D 171-500 order
       Region 1ias E 171-500 order
       Region 3faa A 171-367 order
       Region 3faa B 171-320 order
       Region 3faa C 171-500 order
       Region 3faa D 171-500 order
       Region 3faa E 171-500 order
       Region 1py5 A 175-199 disorder
Seqphosphorylation
    191-191 Phosphoserine; by TGFBR2
    189-189 Phosphoserine; by TGFBR2
    187-187 Phosphoserine; by TGFBR2
    186-186 Phosphothreonine; by TGFBR2
    165-165 Phosphoserine
    185-185 Phosphothreonine; by TGFBR2
 
Prediction
NeProc
Disorder 1-11,105-125,149-191
Order 12-104,126-148,192-503
ProS 10-11,105-125,149-184
AlphaFold
Disorder 1-32,113-126,152-199,369-369,371-371,502-503
Order 33-112,127-151,200-368,370-370,372-501
Pfam Hmmer
PF01064 34-114 9.5e-26
PF08515 175-203 1.1e-15
PF00069 205-492 6.5e-61
SEG 3-34
Function
Function in SwissProt
Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
Biological Process
See also
Diagram with PDB data
SMAD7/SMURF2Solution structure of Smurf2 WW3 domain-Smad7 PY peptide complex