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IID00414
 UniprotP37173
ProteinTGF-beta receptor type-2
GeneTGFBR2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
567
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 24-149 Hetero hexamer : IID00355Complex,IID00413Complex
 Evidence X-RAY 2pjy B Reference
       Region 2pjy B 24-42 disorder
       Region 2pjy B 42-149 order
       Region 2pjy B 43-149 order
Seq 38-153 Hetero hexamer : IID00413Complex,IID00534Complex
 Evidence X-RAY 3kfd H Reference
       Region 3kfd H 38-43 disorder
       Region 3kfd H 44-149 order
       Region 3kfd H 150-153 disorder
 Evidence X-RAY 3kfd G Reference
       Region 3kfd G 38-42 disorder
       Region 3kfd G 43-151 order
       Region 3kfd G 152-153 disorder
 Evidence X-RAY 3kfd F Reference
       Region 3kfd F 38-43 disorder
       Region 3kfd F 44-149 order
       Region 3kfd F 150-153 disorder
 Evidence X-RAY 3kfd E Reference
       Region 3kfd E 38-43 disorder
       Region 3kfd E 44-151 order
       Region 3kfd E 152-153 disorder
Seq 38-153 Hetero dimer : P61812
 Evidence X-RAY 5tx4 A Reference
       Region 5tx4 A 38-43 disorder
       Region 5tx4 A 44-150 order
       Region 5tx4 A 151-153 disorder
Seq 38-159 Hetero tetramer : IID00355Complex
 Evidence X-RAY 1ktz B Reference
       Region 1ktz B 38-47 disorder
       Region 1ktz B 48-153 order
       Region 1ktz B 154-159 disorder
Seq 38-159 Monomer :
 Evidence NMR 1plo A Reference
       Region 1plo A 38-48 disorder
       Region 1plo A 38-45 high_rmsd
       Region 1plo A 49-149 order
       Region 1plo A 150-159 disorder
       Region 1plo A 152-159 high_rmsd
 Evidence X-RAY 4xjj A Reference
       Region 4xjj A 50-153 order
       Region 4xjj A 154-159 disorder
 Evidence X-RAY 4p7u A Reference
       Region 4p7u A 49-150 order
       Region 4p7u A 151-159 disorder
 Evidence X-RAY 1m9z A Reference
       Region 1m9z A 49-153 order
       Region 1m9z A 154-159 disorder
Seq 237-549 Monomer :
 Evidence X-RAY 5e92 A Reference
       Region 5e92 A 237-239 disorder
       Region 5e92 A 240-264 order
       Region 5e92 A 265-270 disorder
       Region 5e92 A 271-543 order
       Region 5e92 A 544-549 disorder
 Evidence X-RAY 5e91 A Reference
       Region 5e91 A 237-239 disorder
       Region 5e91 A 240-264 order
       Region 5e91 A 265-271 disorder
       Region 5e91 A 272-543 order
       Region 5e91 A 544-549 disorder
 Evidence X-RAY 5e8y A Reference
       Region 5e8y A 237-239 disorder
       Region 5e8y A 240-265 order
       Region 5e8y A 266-269 disorder
       Region 5e8y A 270-541 order
       Region 5e8y A 542-549 disorder
 Evidence X-RAY 5e8v A Reference
       Region 5e8v A 237-239 disorder
       Region 5e8v A 240-264 order
       Region 5e8v A 265-270 disorder
       Region 5e8v A 271-541 order
       Region 5e8v A 542-549 disorder
SeqProS possible 43-47 The region 24-48 is described to be disordered in the free state. (PubMed=18243111) Hetero hexamer : IID00413Complex,IID00534Complex
       Region 3kfd E 44-151 order
       Region 3kfd F 44-149 order
       Region 3kfd G 43-151 order
       Region 3kfd H 44-149 order
SeqProS possible 43-47 The region 24-48 is described to be disordered in the free state. (PubMed=18243111) Hetero hexamer : IID00355Complex,IID00413Complex
       Region 2pjy B 43-149 order
Seqphosphorylation
    553-553 Phosphoserine
    409-409 Phosphoserine
    548-548 Phosphoserine
 
Prediction
NeProc
Disorder 1-39,150-166,190-236,549-567
Order 45-149,167-189,237-548
ProS 1-39,162-166,190-203,215-220,232-236,549-563
AlphaFold
Disorder 1-47,151-162,196-239,267-268,417-417,549-567
Order 48-150,163-195,240-266,269-416,418-548
Pfam Hmmer
PF00069 244-538 6.8e-52
Function
Function in SwissProt
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.