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IID00420
 UniprotQ96QZ7
ProteinMembrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
GeneMAGI1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1491
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 295-338 Monomer :
 Evidence NMR 2ysd A Reference
       Region 2ysd A 295-338 order
       Region 2ysd A 295-296 high_rmsd
       Region 2ysd A 336-338 high_rmsd
Seq 355-401 Monomer :
 Evidence NMR 2yse A Reference
       Region 2yse A 355-401 order
 Evidence NMR 2zaj A Reference
       Region 2zaj A 355-390 order
Seq 454-558 Hetero trimer : IID00700Complex,IID00726Complex
 Evidence X-RAY 5n7f A Reference
       Region 5n7f A 454-455 disorder
       Region 5n7f A 456-558 order
 Evidence X-RAY 5n7f B Reference
       Region 5n7f B 454-458 disorder
       Region 5n7f B 459-556 order
       Region 5n7f B 557-558 disorder
Seq 455-558 Hetero trimer : IID00700Complex,IID00726Complex
 Evidence X-RAY 5n7d A Reference
       Region 5n7d A 455-455 disorder
       Region 5n7d A 456-558 order
 Evidence X-RAY 5n7d B Reference
       Region 5n7d B 455-458 disorder
       Region 5n7d B 459-558 order
Seqdisorder 455-558
 Evidence X-RAY 5n7g B Reference
       Region 5n7g B 455-558 disorder
Seq 455-558 Hetero trimer : IID00700Complex,IID00726Complex
 Evidence X-RAY 5n7g A Reference
       Region 5n7g A 455-455 disorder
       Region 5n7g A 456-558 order
Seq 455-580 Hetero dimer : IID90005Complex
 Evidence NMR 2kpl A Reference
       Region 2kpl A 455-580 order
       Region 2kpl A 455-455 high_rmsd
       Region 2kpl A 565-580 high_rmsd
Seq 455-580 Monomer :
 Evidence NMR 2kpk A Reference
       Region 2kpk A 455-580 order
       Region 2kpk A 562-580 high_rmsd
Seq 640-721 Monomer :
 Evidence X-RAY 3bpu A Reference
       Region 3bpu A 640-673 order
       Region 3bpu A 674-675 disorder
       Region 3bpu A 676-721 order
Seq 839-922 Monomer :
 Evidence X-RAY 2q9v A Reference
       Region 2q9v A 839-922 order
Seq 1149-1233 Monomer :
 Evidence X-RAY 2r4h A Reference
       Region 2r4h A 1149-1233 order
 Evidence X-RAY 2r4h B Reference
       Region 2r4h B 1149-1233 order
 Evidence X-RAY 2r4h C Reference
       Region 2r4h C 1149-1233 order
Seqphosphorylation
    800-800 Phosphoserine
    357-357 Phosphoserine
    730-730 Phosphoserine
    741-741 Phosphoserine
    1071-1071 Phosphoserine
    1361-1361 Phosphoserine
    1412-1412 Phosphoserine
 
Prediction
NeProc
Disorder 1-6,209-375,429-465,482-486,563-641,727-833,927-1011,1017-1022,1081-1147,1237-1491
Order 7-208,376-428,466-481,487-562,642-726,834-926,1012-1016,1031-1080,1148-1236
ProS 209-214,219-234,246-256,267-274,289-375,429-429,458-465,482-486,622-628,727-735,778-783,790-805,811-833,995-1011,1081-1092,1237-1240,1461-1467,1479-1491
AlphaFold
Disorder 1-9,49-62,197-300,333-360,363-363,372-373,404-458,559-639,660-665,722-792,794-836,925-995,1015-1035,1094-1148,1240-1491
Order 10-48,63-196,301-332,361-362,364-371,374-403,459-558,640-659,666-721,793-793,837-924,996-1014,1036-1093,1149-1239
Pfam Hmmer
PF00625 146-241 7e-06
PF00397 302-331 2.3e-13
PF00397 361-390 1.2e-10
PF00595 472-553 1.5e-06
PF00595 643-720 4.1e-10
PF00595 841-922 6.2e-13
PF00595 998-1091 1e-18
PF00595 1152-1231 1.4e-14
SEG 44-77 ,402-421 ,433-447 ,741-754 ,968-994 ,1333-1344 ,1375-1443
Function
Function in SwissProt
May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).
Biological Process
See also
Diagram with PDB data
RPS6KA1/MAPK1Heterodimeric structure of ERK2 and RSK1