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IID00421
 UniprotQ9H9A7
ProteinRecQ-mediated genome instability protein 1
GeneRMI1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
625
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-219 Hetero dimer : Q13472
 Evidence X-RAY 4cgy B Reference
       Region 4cgy B 1-1 disorder
       Region 4cgy B 2-120 order
       Region 4cgy B 121-130 disorder
       Region 4cgy B 131-216 order
       Region 4cgy B 217-219 disorder
 Evidence X-RAY 4cht B Reference
       Region 4cht B 1-1 disorder
       Region 4cht B 2-216 order
       Region 4cht B 217-219 disorder
Seq 2-213 Monomer :
 Evidence X-RAY 3nbi A Reference
       Region 3nbi A 2-109 order
       Region 3nbi A 110-119 disorder
       Region 3nbi A 120-204 order
       Region 3nbi A 205-213 disorder
Seq 473-625 Hetero trimer : IID00419Complex,IID00484Complex
 Evidence X-RAY 4day A Reference
       Region 4day A 473-481 disorder
       Region 4day A 482-625 order
Seq 473-625 Hetero dimer : IID00419Complex
 Evidence X-RAY 3mxn A Reference
       Region 3mxn A 473-474 disorder
       Region 3mxn A 475-625 order
 Evidence X-RAY 3nbh A Reference
       Region 3nbh A 475-475 disorder
       Region 3nbh A 476-625 order
Seqphosphorylation
    292-292 Phosphoserine
    284-284 Phosphoserine
    225-225 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-6,114-129,219-486
Order 7-113,130-217,487-625
ProS 114-129,219-262,266-273,287-290,297-320,332-427,435-452,464-486
AlphaFold
Disorder 1-1,120-121,123-123,128-130,215-244,246-484,625-625
Order 2-119,122-122,124-127,131-214,245-245,485-624
Pfam Hmmer
PF08585 12-104 5.4e-39
Function
Function in SwissProt
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
Biological Process
See also
Diagram with PDB data
FANCM/RMI1/RMI2Crystal structure of the RMI core complex with MM2 peptide from FANCM