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IID00422
 UniprotQ9UKL0
ProteinREST corepressor 1
GeneRCOR1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
485
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 4-485 Hetero trimer : IID00009Complex
 Evidence X-RAY 3zn0 B Reference
       Region 3zn0 B 4-310 disorder
       Region 3zn0 B 311-443 order
       Region 3zn0 B 444-485 disorder
Seq 4-485 Hetero trimer : IID00009Complex
 Evidence X-RAY 3zn1 B Reference
       Region 3zn1 B 4-310 disorder
       Region 3zn1 B 311-443 order
       Region 3zn1 B 444-485 disorder
Seq 4-485 Hetero trimer : IID00009Complex
 Evidence X-RAY 3zms B Reference
       Region 3zms B 4-310 disorder
       Region 3zms B 311-443 order
       Region 3zms B 444-485 disorder
Seq 4-485 Hetero trimer : IID00009Complex
 Evidence X-RAY 3zmu B Reference
       Region 3zmu B 4-310 disorder
       Region 3zmu B 311-443 order
       Region 3zmu B 444-485 disorder
Seq 4-485 Hetero tetramer : IID00009Complex
 Evidence X-RAY 3zmv B Reference
       Region 3zmv B 4-310 disorder
       Region 3zmv B 311-443 order
       Region 3zmv B 444-485 disorder
Seq 4-485 Hetero trimer : IID00009Complex
 Evidence X-RAY 3zmt B Reference
       Region 3zmt B 4-310 disorder
       Region 3zmt B 311-443 order
       Region 3zmt B 444-485 disorder
Seq 4-485 Hetero trimer : IID00009Complex
 Evidence X-RAY 3zmz B Reference
       Region 3zmz B 4-310 disorder
       Region 3zmz B 311-443 order
       Region 3zmz B 444-485 disorder
Seq 4-485 Hetero dimer : IID00009Complex
 Evidence X-RAY 2iw5 B Reference
       Region 2iw5 B 289-310 disorder
       Region 2iw5 B 311-443 order
       Region 2iw5 B 444-485 disorder
 Evidence X-RAY 2uxx B Reference
       Region 2uxx B 289-310 disorder
       Region 2uxx B 311-444 order
       Region 2uxx B 445-485 disorder
 Evidence X-RAY 2xaf B Reference
       Region 2xaf B 4-310 disorder
       Region 2xaf B 311-443 order
       Region 2xaf B 444-485 disorder
 Evidence X-RAY 2xag B Reference
       Region 2xag B 4-310 disorder
       Region 2xag B 311-443 order
       Region 2xag B 444-485 disorder
 Evidence X-RAY 2xah B Reference
       Region 2xah B 4-310 disorder
       Region 2xah B 311-443 order
       Region 2xah B 444-485 disorder
 Evidence X-RAY 2xaj B Reference
       Region 2xaj B 4-310 disorder
       Region 2xaj B 311-443 order
       Region 2xaj B 444-485 disorder
 Evidence X-RAY 2xaq B Reference
       Region 2xaq B 4-310 disorder
       Region 2xaq B 311-443 order
       Region 2xaq B 444-485 disorder
 Evidence X-RAY 2xas B Reference
       Region 2xas B 4-310 disorder
       Region 2xas B 311-443 order
       Region 2xas B 444-485 disorder
 Evidence X-RAY 4bay B Reference
       Region 4bay B 311-443 order
 Evidence X-RAY 4kum B Reference
       Region 4kum B 289-310 disorder
       Region 4kum B 311-443 order
       Region 4kum B 444-485 disorder
 Evidence X-RAY 4uv8 B Reference
       Region 4uv8 B 4-310 disorder
       Region 4uv8 B 311-443 order
       Region 4uv8 B 444-485 disorder
 Evidence X-RAY 4uv9 B Reference
       Region 4uv9 B 4-310 disorder
       Region 4uv9 B 311-443 order
       Region 4uv9 B 444-485 disorder
 Evidence X-RAY 4uva B Reference
       Region 4uva B 4-310 disorder
       Region 4uva B 311-443 order
       Region 4uva B 444-485 disorder
 Evidence X-RAY 4uvb B Reference
       Region 4uvb B 4-310 disorder
       Region 4uvb B 311-443 order
       Region 4uvb B 444-485 disorder
 Evidence X-RAY 4uvc B Reference
       Region 4uvc B 4-310 disorder
       Region 4uvc B 311-443 order
       Region 4uvc B 444-485 disorder
 Evidence X-RAY 4uxn B Reference
       Region 4uxn B 4-310 disorder
       Region 4uxn B 311-443 order
       Region 4uxn B 444-485 disorder
 Evidence X-RAY 5l3b B Reference
       Region 5l3b B 4-310 disorder
       Region 5l3b B 311-443 order
       Region 5l3b B 444-485 disorder
 Evidence X-RAY 5l3c B Reference
       Region 5l3c B 4-310 disorder
       Region 5l3c B 311-444 order
       Region 5l3c B 445-485 disorder
 Evidence X-RAY 5l3d B Reference
       Region 5l3d B 4-310 disorder
       Region 5l3d B 311-443 order
       Region 5l3d B 444-485 disorder
 Evidence X-RAY 5l3e B Reference
       Region 5l3e B 308-310 disorder
       Region 5l3e B 311-443 order
       Region 5l3e B 444-485 disorder
 Evidence X-RAY 5l3f B Reference
       Region 5l3f B 308-310 disorder
       Region 5l3f B 311-443 order
       Region 5l3f B 444-485 disorder
 Evidence X-RAY 5l3g B Reference
       Region 5l3g B 308-310 disorder
       Region 5l3g B 311-443 order
       Region 5l3g B 444-485 disorder
 Evidence X-RAY 5lbq B Reference
       Region 5lbq B 308-310 disorder
       Region 5lbq B 311-443 order
       Region 5lbq B 444-485 disorder
 Evidence X-RAY 5lgn B Reference
       Region 5lgn B 311-443 order
 Evidence X-RAY 5lgt B Reference
       Region 5lgt B 308-310 disorder
       Region 5lgt B 311-443 order
       Region 5lgt B 444-485 disorder
 Evidence X-RAY 5lgu B Reference
       Region 5lgu B 308-310 disorder
       Region 5lgu B 311-443 order
       Region 5lgu B 444-485 disorder
 Evidence X-RAY 5lhg B Reference
       Region 5lhg B 4-310 disorder
       Region 5lhg B 311-443 order
       Region 5lhg B 444-485 disorder
 Evidence X-RAY 5lhh B Reference
       Region 5lhh B 4-310 disorder
       Region 5lhh B 311-443 order
       Region 5lhh B 444-485 disorder
 Evidence X-RAY 5lhi B Reference
       Region 5lhi B 4-310 disorder
       Region 5lhi B 311-443 order
       Region 5lhi B 444-485 disorder
Seq 289-485 Hetero trimer : IID00009Complex
 Evidence X-RAY 2uxn B Reference
       Region 2uxn B 289-310 disorder
       Region 2uxn B 311-443 order
       Region 2uxn B 444-485 disorder
Seq 308-485 Hetero trimer : IID00009Complex
 Evidence X-RAY 2v1d B Reference
       Region 2v1d B 308-310 disorder
       Region 2v1d B 311-443 order
       Region 2v1d B 444-485 disorder
Seq 308-485 Hetero trimer : IID00009Complex
 Evidence X-RAY 2y48 B Reference
       Region 2y48 B 308-310 disorder
       Region 2y48 B 311-443 order
       Region 2y48 B 444-485 disorder
Seq 311-443 Hetero octamer : IID00009Complex
 Evidence X-RAY 4xbf B Reference
       Region 4xbf B 311-443 order
Seq 311-443 Hetero trimer : IID00009Complex
 Evidence X-RAY 2x0l B Reference
       Region 2x0l B 311-443 order
 Evidence X-RAY 5h6q B Reference
       Region 5h6q B 311-311 disorder
       Region 5h6q B 312-442 order
       Region 5h6q B 443-443 disorder
 Evidence X-RAY 5h6r B Reference
       Region 5h6r B 311-311 disorder
       Region 5h6r B 312-443 order
 Evidence X-RAY 5x60 B Reference
       Region 5x60 B 311-311 disorder
       Region 5x60 B 312-443 order
Seqphosphorylation
    460-460 Phosphoserine
    260-260 Phosphoserine
    127-127 Phosphoserine
 
Prediction
NeProc
Disorder 1-103,271-330,366-385,439-485
Order 104-270,331-365,386-438
ProS 6-20,70-72,78-83,100-103,271-284,289-314,320-322,369-376,382-385,439-444,477-481
AlphaFold
Disorder 1-104,126-133,189-194,239-310,445-485
Order 105-125,134-188,195-238,311-444
Pfam Hmmer
PF01448 103-167 6.2e-25
PF00249 192-237 2.1e-09
PF00249 383-428 8.9e-11
SEG 21-64 ,74-104 ,256-266 ,324-337
Function
Function in SwissProt
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
Biological Process
See also
Diagram with PDB data
REST/Sin3bSolution structure of the NRSF/REST-mSin3B PAH1 complex