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IID00423
 UniprotA5YKK6
ProteinCCR4-NOT transcription complex subunit 1
GeneCNOT1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2376
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 800-821,827-1004 Hetero dimer : IID00655Complex
 Evidence X-RAY 4j8s A Reference
       Region 4j8s A 800-819 disorder
       Region 4j8s A 820-821 order
       Region 4j8s A 827-1004 order
Seq 1063-1314 Hetero trimer : IID00712Complex
 Evidence X-RAY 5anr A Reference
       Region 5anr A 1063-1069 disorder
       Region 5anr A 1070-1314 order
Seq 1063-1314 Hetero dimer : IID00712Complex
 Evidence X-RAY 4ct4 C Reference
       Region 4ct4 C 1063-1068 disorder
       Region 4ct4 C 1069-1310 order
       Region 4ct4 C 1311-1314 disorder
 Evidence X-RAY 4ct4 A Reference
       Region 4ct4 A 1063-1070 disorder
       Region 4ct4 A 1071-1306 order
       Region 4ct4 A 1307-1314 disorder
Seq 1093-1317 Monomer :
 Evidence X-RAY 4gml F Reference
       Region 4gml F 1093-1317 order
 Evidence X-RAY 4gml E Reference
       Region 4gml E 1093-1317 order
 Evidence X-RAY 4gml D Reference
       Region 4gml D 1093-1317 order
 Evidence X-RAY 4gml C Reference
       Region 4gml C 1093-1181 order
       Region 4gml C 1182-1184 disorder
       Region 4gml C 1185-1317 order
 Evidence X-RAY 4gml B Reference
       Region 4gml B 1093-1317 order
 Evidence X-RAY 4gml A Reference
       Region 4gml A 1093-1317 order
Seq 1093-1317 Hetero dimer : IID00504Complex
 Evidence X-RAY 4gmj E Reference
       Region 4gmj E 1093-1317 order
 Evidence X-RAY 4gmj C Reference
       Region 4gmj C 1093-1317 order
 Evidence X-RAY 4gmj A Reference
       Region 4gmj A 1093-1317 order
Seq 1093-1317 Hetero dimer : IID00712Complex
 Evidence X-RAY 4crw A Reference
       Region 4crw A 1093-1317 order
Seq 1351-1588 Hetero trimer : Q92600
 Evidence X-RAY 5ona D Reference
       Region 5ona D 1351-1475 order
       Region 5ona D 1476-1479 disorder
       Region 5ona D 1480-1588 order
 Evidence X-RAY 5ona A Reference
       Region 5ona A 1351-1352 disorder
       Region 5ona A 1353-1588 order
Seq 1352-1607 Hetero dimer : Q92600
 Evidence X-RAY 4ct7 A Reference
       Region 4ct7 A 1352-1588 order
       Region 4ct7 A 1589-1594 disorder
 Evidence X-RAY 4ct6 A Reference
       Region 4ct6 A 1352-1588 order
       Region 4ct6 A 1589-1594 disorder
 Evidence X-RAY 4crv A Reference
       Region 4crv A 1356-1587 order
       Region 4crv A 1588-1602 disorder
       Region 4crv A 1603-1603 order
       Region 4crv A 1604-1607 disorder
 Evidence X-RAY 4cru A Reference
       Region 4cru A 1356-1588 order
       Region 4cru A 1589-1600 disorder
       Region 4cru A 1601-1604 order
       Region 4cru A 1605-1607 disorder
Seq 1565-2371 Hetero trimer : IID00434Complex,IID00503Complex
 Evidence X-RAY 4c0d A Reference
       Region 4c0d A 1565-1841 disorder
       Region 4c0d A 1842-2353 order
       Region 4c0d A 2354-2371 disorder
Seq 1833-2361 Hetero hexamer : IID00434Complex,IID00503Complex
 Evidence X-RAY 5fu6 D Reference
       Region 5fu6 D 1833-1841 disorder
       Region 5fu6 D 1842-2003 order
       Region 5fu6 D 2004-2007 disorder
       Region 5fu6 D 2008-2361 order
 Evidence X-RAY 5fu6 A Reference
       Region 5fu6 A 1833-1841 disorder
       Region 5fu6 A 1842-2004 order
       Region 5fu6 A 2005-2009 disorder
       Region 5fu6 A 2010-2361 order
Seq 1833-2361 Hetero dimer : IID00517Complex
 Evidence X-RAY 4cqo A Reference
       Region 4cqo A 1833-1841 disorder
       Region 4cqo A 1842-1916 order
       Region 4cqo A 1917-1924 disorder
       Region 4cqo A 1925-2082 order
       Region 4cqo A 2083-2084 disorder
       Region 4cqo A 2085-2361 order
 Evidence X-RAY 4cqo C Reference
       Region 4cqo C 1833-1841 disorder
       Region 4cqo C 1842-1921 order
       Region 4cqo C 1922-1925 disorder
       Region 4cqo C 1926-2361 order
Seq 1833-2361 Hetero octamer : A0A0B4KGY5,IID00434Complex,IID00503Complex
 Evidence X-RAY 5fu7 E Reference
       Region 5fu7 E 1833-1840 disorder
       Region 5fu7 E 1841-2003 order
       Region 5fu7 E 2004-2010 disorder
       Region 5fu7 E 2011-2361 order
 Evidence X-RAY 5fu7 A Reference
       Region 5fu7 A 1833-1838 disorder
       Region 5fu7 A 1839-2003 order
       Region 5fu7 A 2004-2007 disorder
       Region 5fu7 A 2008-2361 order
Seqphosphorylation
    1061-1061 Phosphoserine
    318-318 Phosphoserine
 
Prediction
NeProc
Disorder 1-5,315-331,631-644,689-840,999-1068,1313-1365,1583-1613,1817-1842,2362-2376
Order 6-59,66-163,171-245,251-314,332-435,443-630,645-659,666-688,841-998,1069-1080,1086-1312,1366-1480,1486-1582,1614-1626,1632-1798,1805-1816,1843-1866,1872-1914,1928-1951,1958-2187,2192-2233,2240-2361
ProS 1-5,318-323,641-644,689-693,1609-1613,1835-1842
AlphaFold
Disorder 1-6,59-66,85-85,163-175,190-197,216-218,220-222,224-225,229-254,279-284,304-334,387-388,438-441,492-496,527-532,549-552,625-625,628-643,677-839,858-863,1002-1074,1081-1087,1182-1186,1318-1354,1478-1478,1550-1550,1553-1553,1555-1557,1561-1563,1585-1606,1653-1653,1673-1676,1720-1720,1753-1754,1772-1779,1781-1781,1798-1802,1814-1829,1840-1843,1866-1872,1917-1923,1953-1953,2082-2082,2148-2149,2206-2207,2356-2356,2358-2376
Order 7-58,67-84,86-162,176-189,198-215,219-219,223-223,226-228,255-278,285-303,335-386,389-437,442-491,497-526,533-548,553-624,626-627,644-676,840-857,864-1001,1075-1080,1088-1181,1187-1317,1355-1477,1479-1549,1551-1552,1554-1554,1558-1560,1564-1584,1607-1652,1654-1672,1677-1719,1721-1752,1755-1771,1780-1780,1782-1797,1803-1813,1830-1839,1844-1865,1873-1916,1924-1952,1954-2081,2083-2147,2150-2205,2208-2355,2357-2357
Pfam Hmmer
PF04054 1996-2376 1.8e-294
SEG 181-189 ,687-698 ,779-796 ,1016-1033 ,1036-1055 ,1114-1125 ,1301-1313 ,1330-1353 ,1490-1497 ,1639-1653
Function
Function in SwissProt
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity.