IDEAL List

IDEAL

IID00424
UniprotA8MT69
ProteinCentromere protein X
GeneCENPX
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 1-81 Hetero pentamer : IID00484Complex,IID00620Complex

Evidence X-RAY 4e45 N Reference

Region 4e45 N 1-7 disorder

Region 4e45 N 8-81 order

Evidence X-RAY 4e45 L Reference

Region 4e45 L 1-7 disorder

Region 4e45 L 8-81 order

Evidence X-RAY 4e45 I Reference

Region 4e45 I 1-7 disorder

Region 4e45 I 8-81 order

Evidence X-RAY 4e45 G Reference

Region 4e45 G 1-7 disorder

Region 4e45 G 8-81 order

Evidence X-RAY 4e45 D Reference

Region 4e45 D 1-7 disorder

Region 4e45 D 8-81 order

Evidence X-RAY 4e45 B Reference

Region 4e45 B 1-7 disorder

Region 4e45 B 8-81 order

Evidence X-RAY 4drb O Reference

Region 4drb O 1-7 disorder

Region 4drb O 8-81 order

Evidence X-RAY 4drb N Reference

Region 4drb N 1-7 disorder

Region 4drb N 8-81 order

Evidence X-RAY 4drb M Reference

Region 4drb M 1-7 disorder

Region 4drb M 8-81 order

Evidence X-RAY 4drb L Reference

Region 4drb L 1-7 disorder

Region 4drb L 8-81 order

Evidence X-RAY 4drb K Reference

Region 4drb K 1-7 disorder

Region 4drb K 8-81 order

Evidence X-RAY 4drb J Reference

Region 4drb J 1-7 disorder

Region 4drb J 8-81 order

Seq 1-81 Hetero tetramer : IID00620Complex

Evidence X-RAY 4ne6 D Reference

Region 4ne6 D 8-81 order

Evidence X-RAY 4ne6 B Reference

Region 4ne6 B 8-81 order

Evidence X-RAY 4ne5 H Reference

Region 4ne5 H 8-81 order

Evidence X-RAY 4ne5 D Reference

Region 4ne5 D 8-81 order

Evidence X-RAY 4ne5 F Reference

Region 4ne5 F 8-81 order

Evidence X-RAY 4ne5 B Reference

Region 4ne5 B 8-81 order

Evidence X-RAY 4ne3 B Reference

Region 4ne3 B 8-81 order

Evidence X-RAY 4ne1 N Reference

Region 4ne1 N 8-81 order

Evidence X-RAY 4ne1 M Reference

Region 4ne1 M 8-81 order

Evidence X-RAY 4ne1 j Reference

Region 4ne1 j 8-81 order

Evidence X-RAY 4ne1 i Reference

Region 4ne1 i 8-81 order

Evidence X-RAY 4ne1 H Reference

Region 4ne1 H 8-81 order

Evidence X-RAY 4ne1 D Reference

Region 4ne1 D 8-81 order

Evidence X-RAY 4ndy N Reference

Region 4ndy N 8-81 order

Evidence X-RAY 4ndy M Reference

Region 4ndy M 8-81 order

Evidence X-RAY 4e44 D Reference

Region 4e44 D 1-6 disorder

Region 4e44 D 7-81 order

Evidence X-RAY 4e44 B Reference

Region 4e44 B 1-6 disorder

Region 4e44 B 7-81 order

Evidence X-RAY 4dra G Reference

Region 4dra G 1-7 disorder

Region 4dra G 8-81 order

Evidence X-RAY 4dra F Reference

Region 4dra F 1-7 disorder

Region 4dra F 8-81 order

Evidence X-RAY 4dra H Reference

Region 4dra H 1-5 disorder

Region 4dra H 6-81 order

Evidence X-RAY 4dra E Reference

Region 4dra E 1-7 disorder

Region 4dra E 8-81 order

Seq 8-81 Hetero tetramer : IID00620Complex

Evidence X-RAY 4ne1 q Reference

Region 4ne1 q 8-81 order

Evidence X-RAY 4ne1 p Reference

Region 4ne1 p 8-81 order

Evidence X-RAY 4ne1 W Reference

Region 4ne1 W 8-81 order

Evidence X-RAY 4ne1 V Reference

Region 4ne1 V 8-81 order

Evidence X-RAY 4ne1 U Reference

Region 4ne1 U 8-81 order

Evidence X-RAY 4ne1 L Reference

Region 4ne1 L 8-81 order

Evidence X-RAY 4ne1 U Reference

Region 4ne1 U 8-81 order

Evidence X-RAY 4ne1 L Reference

Region 4ne1 L 8-81 order

Evidence X-RAY 4ndy W Reference

Region 4ndy W 8-81 order

Evidence X-RAY 4ndy V Reference

Region 4ndy V 8-81 order

Seq 8-81 Hetero tetramer : IID00620Complex

Evidence X-RAY 4ne1 X Reference

Region 4ne1 X 8-81 order

Evidence X-RAY 4ne1 B Reference

Region 4ne1 B 8-81 order

Evidence X-RAY 4ndy X Reference

Region 4ndy X 8-81 order

Evidence X-RAY 4ndy B Reference

Region 4ndy B 8-81 order

Seq 8-81 Hetero tetramer : IID00620Complex

Evidence X-RAY 4ne1 o Reference

Region 4ne1 o 8-81 order

Evidence X-RAY 4ndy U Reference

Region 4ndy U 8-81 order

Evidence X-RAY 4ndy L Reference

Region 4ndy L 8-81 order

Seq 8-81 Hetero tetramer : IID00620Complex

Evidence X-RAY 4ne1 r Reference

Region 4ne1 r 8-81 order

Evidence X-RAY 4ne1 Z Reference

Region 4ne1 Z 8-81 order

Evidence X-RAY 4ndy H Reference

Region 4ndy H 8-81 order

Evidence X-RAY 4ndy D Reference

Region 4ndy D 8-81 order

Seqacetylation

1-1 N-acetylmethionine

Prediction

NeProc

Disorder 1-8

Order 9-81

AlphaFold

Disorder 1-7

Order 8-81

Function

Function in SwissProt

DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:20347429). DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347429).

Biological Process

See also
Diagram with PDB data
FANCM/CENPS/CENPX	The crystal structure of FANCM bound MHF complex