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IID00427
 UniprotO14593
ProteinDNA-binding protein RFXANK
GeneRFXANK
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
260
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 90-260 Hetero tetramer : Q2KHR2
 Evidence X-RAY 4qqm A Reference
       Region 4qqm A 90-91 disorder
       Region 4qqm A 92-252 order
       Region 4qqm A 253-260 disorder
 Evidence X-RAY 4qqm C Reference
       Region 4qqm C 90-90 disorder
       Region 4qqm C 91-252 order
       Region 4qqm C 253-260 disorder
Seq 90-260 Hetero dimer : IID00457Complex
 Evidence X-RAY 3uxg A Reference
       Region 3uxg A 90-90 disorder
       Region 3uxg A 91-253 order
       Region 3uxg A 254-260 disorder
Seq 90-260 Hetero dimer : IID00452Complex
 Evidence X-RAY 3v30 A Reference
       Region 3v30 A 90-91 disorder
       Region 3v30 A 92-252 order
       Region 3v30 A 253-260 disorder
 
Prediction
NeProc
Order 1-260
AlphaFold
Disorder 1-90,253-260
Order 91-252
Pfam Hmmer
PF00023 123-155 1.6e-06
PF00023 189-221 2.1e-06
Function
Function in SwissProt
Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (PubMed:9806546, PubMed:10072068, PubMed:10725724). May also potentiate the activation of RAF1 (By similarity).
Isoform 2 is not involved in the positive regulation of MHC class II genes.
Biological Process
Diagram with PDB data
RFXANK/FRX5Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human RFXANK
See also
Diagram with PDB data
HDAC4/RFXANKCrystal structure of RFXANK