IID00427
 UniprotO14593
ProteinDNA-binding protein RFXANK
GeneRFXANK
OrganismHomo sapiens
Sequence LLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
260
 order/disorder by at least rule
 order/disorder by majority rule
 
Prediction
NeProc
AlphaFold
Pfam Hmmer
Function
Function in SwissProt
Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (PubMed:9806546, PubMed:10072068, PubMed:10725724). May also potentiate the activation of RAF1 (By similarity).
Isoform 2 is not involved in the positive regulation of MHC class II genes.
Biological Process
Diagram with PDB data
RFXANK/FRX5Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human RFXANK
See also
Diagram with PDB data
HDAC4/RFXANKCrystal structure of RFXANK