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IID00429
 UniprotO15409
ProteinForkhead box protein P2
GeneFOXP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
715
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 502-594 Homo hexamer :
 Evidence X-RAY 2a07 K Reference
       Region 2a07 K 502-584 order
       Region 2a07 K 585-594 disorder
 Evidence X-RAY 2a07 J Reference
       Region 2a07 J 502-584 order
       Region 2a07 J 585-594 disorder
 Evidence X-RAY 2a07 I Reference
       Region 2a07 I 502-502 disorder
       Region 2a07 I 503-583 order
       Region 2a07 I 584-594 disorder
 Evidence X-RAY 2a07 H Reference
       Region 2a07 H 502-505 disorder
       Region 2a07 H 506-584 order
       Region 2a07 H 585-594 disorder
 Evidence X-RAY 2a07 G Reference
       Region 2a07 G 502-505 disorder
       Region 2a07 G 506-584 order
       Region 2a07 G 585-594 disorder
 Evidence X-RAY 2a07 F Reference
       Region 2a07 F 502-502 disorder
       Region 2a07 F 503-584 order
       Region 2a07 F 585-594 disorder
Seq 502-594 Hetero dimer : IID00470Complex
 Evidence X-RAY 2as5 G Reference
       Region 2as5 G 502-584 order
       Region 2as5 G 585-594 disorder
 Evidence X-RAY 2as5 F Reference
       Region 2as5 F 502-584 order
       Region 2as5 F 585-594 disorder
 
Prediction
NeProc
Disorder 1-135,193-202,231-340,387-390,399-476,583-715
Order 136-192,203-230,341-386,391-398,477-582
ProS 5-11,118-135,231-239,270-274,315-321,387-390,399-412,590-598,610-614,622-627,639-654,670-676,700-715
AlphaFold
Disorder 1-50,61-61,64-114,188-207,232-232,234-340,411-494,585-715
Order 51-60,62-63,115-187,208-231,233-233,341-410,495-584
Pfam Hmmer
PF00250 504-613 3.1e-28
SEG 30-42 ,49-69 ,101-239 ,292-305 ,321-332 ,438-459 ,606-625 ,698-715
Function
Function in SwissProt
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
Biological Process
See also
Diagram with PDB data
NFATC2/FOXP2/DNAStructure of the DNA binding domains of NFAT and FOXP2 bound specifically to DNA.