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IID00431
 UniprotO15550
ProteinLysine-specific demethylase 6A
GeneKDM6A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1401
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 880-1401 Hetero dimer : IID00062Complex
 Evidence X-RAY 3avr A Reference
       Region 3avr A 880-885 disorder
       Region 3avr A 886-902 order
       Region 3avr A 903-909 disorder
       Region 3avr A 910-1047 order
       Region 3avr A 1048-1077 disorder
       Region 3avr A 1078-1395 order
       Region 3avr A 1396-1401 disorder
Seq 880-1401 Monomer :
 Evidence X-RAY 3avs A Reference
       Region 3avs A 880-885 disorder
       Region 3avs A 886-902 order
       Region 3avs A 903-909 disorder
       Region 3avs A 910-1048 order
       Region 3avs A 1049-1077 disorder
       Region 3avs A 1078-1395 order
       Region 3avs A 1396-1401 disorder
Seqphosphorylation
    829-829 Phosphoserine
    827-827 Phosphothreonine
    769-769 Phosphoserine
 
Prediction
NeProc
Disorder 1-16,312-319,325-329,398-877,1050-1077,1396-1401
Order 17-311,320-324,330-397,878-925,928-1049,1078-1395
ProS 312-319,325-329,398-402,446-451,456-460,473-481,493-498,640-643,652-659,775-779,788-793,851-877,1050-1056,1073-1077
AlphaFold
Disorder 1-39,60-65,88-88,315-315,382-383,403-414,425-469,507-886,902-912,1054-1077,1396-1401
Order 40-59,66-87,89-314,316-381,384-402,415-424,470-506,887-901,913-1053,1078-1395
Pfam Hmmer
PF00515 130-163 3.1e-06
PF00515 318-351 2.1e-05
PF02373 1133-1241 2.1e-50
SEG 9-17 ,26-40 ,814-833 ,919-932 ,972-983 ,1055-1071
Function
Function in SwissProt
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity).