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IID00432
 UniprotO43189
ProteinPHD finger protein 1
GenePHF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
567
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 6-83 Hetero dimer : IID00062Complex
 Evidence NMR 2m0o A Reference
       Region 2m0o A 6-83 order
       Region 2m0o A 6-28 high_rmsd
       Region 2m0o A 83-83 high_rmsd
Seq 25-340 Monomer :
 Evidence X-RAY 5xfo A Reference
       Region 5xfo A 25-25 disorder
       Region 5xfo A 26-340 order
 Evidence X-RAY 5xfn A Reference
       Region 5xfn A 25-25 disorder
       Region 5xfn A 26-126 order
       Region 5xfn A 127-132 disorder
       Region 5xfn A 133-319 order
       Region 5xfn A 320-326 disorder
       Region 5xfn A 327-339 order
       Region 5xfn A 340-340 disorder
Seq 25-360 Homo trimer :
 Evidence X-RAY 5xfp A Reference
       Region 5xfp A 25-28 disorder
       Region 5xfp A 29-126 order
       Region 5xfp A 127-132 disorder
       Region 5xfp A 133-340 order
       Region 5xfp A 341-360 disorder
 Evidence X-RAY 5xfp B Reference
       Region 5xfp B 25-29 disorder
       Region 5xfp B 30-126 order
       Region 5xfp B 127-132 disorder
       Region 5xfp B 133-340 order
       Region 5xfp B 341-360 disorder
 Evidence X-RAY 5xfp E Reference
       Region 5xfp E 25-29 disorder
       Region 5xfp E 30-126 order
       Region 5xfp E 127-132 disorder
       Region 5xfp E 133-321 order
       Region 5xfp E 322-326 disorder
       Region 5xfp E 327-340 order
       Region 5xfp E 341-360 disorder
Seq 28-85 Hetero dimer : IID00482Complex
 Evidence X-RAY 4hcz B Reference
       Region 4hcz B 28-84 order
       Region 4hcz B 85-85 disorder
 Evidence X-RAY 4hcz A Reference
       Region 4hcz A 28-85 order
Seq 29-83 Monomer :
 Evidence NMR 2e5p A Reference
       Region 2e5p A 29-83 order
Seqphosphorylation
    420-420 Phosphoserine
    360-360 Phosphoserine
 
Prediction
NeProc
Disorder 1-28,149-166,343-529
Order 29-78,84-148,167-341,530-567
ProS 1-8,356-366,394-410,421-441,451-459,479-485,508-512
AlphaFold
Disorder 1-27,130-132,321-324,341-401,411-542,562-567
Order 28-129,133-320,325-340,402-410,543-561
Pfam Hmmer
PF00628 89-142 6.2e-12
SEG 363-379 ,415-433 ,456-470 ,488-534
Function
Function in SwissProt
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.