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IID00434
 UniprotO75175
ProteinCCR4-NOT transcription complex subunit 3
GeneCNOT3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
753
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 607-748 Hetero hexamer : IID00423Complex,IID00503Complex
 Evidence X-RAY 5fu6 F Reference
       Region 5fu6 F 607-748 order
 Evidence X-RAY 5fu6 C Reference
       Region 5fu6 C 607-748 order
Seq 607-748 Hetero octamer : A0A0B4KGY5,IID00423Complex,IID00503Complex
 Evidence X-RAY 5fu7 G Reference
       Region 5fu7 G 607-748 order
 Evidence X-RAY 5fu7 C Reference
       Region 5fu7 C 607-748 order
Seq 607-753 Hetero trimer : IID00423Complex,IID00503Complex
 Evidence X-RAY 4c0d C Reference
       Region 4c0d C 607-748 order
       Region 4c0d C 749-753 disorder
Seq 656-753 Homo dimer :
 Evidence X-RAY 4c0g F Reference
       Region 4c0g F 656-657 disorder
       Region 4c0g F 658-750 order
       Region 4c0g F 751-753 disorder
 Evidence X-RAY 4c0g C Reference
       Region 4c0g C 656-750 order
       Region 4c0g C 751-753 disorder
 Evidence X-RAY 4c0g E Reference
       Region 4c0g E 656-657 disorder
       Region 4c0g E 658-748 order
       Region 4c0g E 749-753 disorder
 Evidence X-RAY 4c0g B Reference
       Region 4c0g B 656-751 order
       Region 4c0g B 752-753 disorder
 Evidence X-RAY 4c0g D Reference
       Region 4c0g D 656-750 order
       Region 4c0g D 751-753 disorder
 Evidence X-RAY 4c0g A Reference
       Region 4c0g A 656-658 disorder
       Region 4c0g A 659-748 order
       Region 4c0g A 749-753 disorder
SeqProS possible 607-655 This region is described to be disordered in the free state. (PubMed=24121232) Hetero trimer : IID00423Complex,IID00503Complex
       Region 4c0d C 607-748 order
SeqProS possible 607-655 This region is described to be disordered in the free state. (PubMed=24121232) Hetero hexamer : IID00423Complex,IID00503Complex
       Region 5fu6 C 607-748 order
       Region 5fu6 F 607-748 order
SeqProS possible 607-655 This region is described to be disordered in the free state. (PubMed=24121232) Hetero octamer : A0A0B4KGY5,IID00423Complex,IID00503Complex
       Region 5fu7 C 607-748 order
       Region 5fu7 G 607-748 order
Seqphosphorylation
    292-292 Phosphothreonine
    299-299 Phosphoserine
    542-542 Phosphoserine
 
Prediction
NeProc
Disorder 1-5,101-108,160-166,232-611,749-753
Order 6-100,109-159,167-231,612-748
ProS 101-108,161-166,232-246,458-464,589-611,749-753
AlphaFold
Disorder 1-1,101-114,154-158,232-604,750-753
Order 2-100,115-153,159-231,605-749
Pfam Hmmer
PF04065 2-242 1.5e-167
PF04153 580-748 4.1e-58
SEG 155-164 ,257-274 ,316-338 ,344-362 ,368-380 ,396-421 ,441-467 ,472-511 ,572-589 ,642-656 ,682-694
Function
Function in SwissProt
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.