Search Keyword:


Search option:


IID00439
UniprotP10826
ProteinRetinoic acid receptor beta
GeneRARB
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
455
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 80-455 Hetero tetramer : IID00031Complex,IID00082Complex
 Evidence X-RAY 5uan B Reference
       Region 5uan B 80-86 disorder
       Region 5uan B 87-159 order
       Region 5uan B 160-180 disorder
       Region 5uan B 181-415 order
       Region 5uan B 416-455 disorder
Seq 82-160 Monomer :
 Evidence NMR 1hra A Reference
       Region 1hra A 82-160 order
Seq 176-421 Hetero dimer : IID00083Complex
 Evidence X-RAY 4dm8 B Reference
       Region 4dm8 B 176-177 disorder
       Region 4dm8 B 178-416 order
       Region 4dm8 B 417-421 disorder
 Evidence X-RAY 4dm8 A Reference
       Region 4dm8 A 176-368 order
       Region 4dm8 A 369-370 disorder
       Region 4dm8 A 371-415 order
       Region 4dm8 A 416-421 disorder
 Evidence X-RAY 4dm6 B Reference
       Region 4dm6 B 176-177 disorder
       Region 4dm6 B 178-416 order
       Region 4dm6 B 417-421 disorder
 Evidence X-RAY 4dm6 A Reference
       Region 4dm6 A 176-415 order
       Region 4dm6 A 416-421 disorder
Seq 176-421 Monomer :
 Evidence X-RAY 1xap A Reference
       Region 1xap A 176-181 disorder
       Region 1xap A 182-368 order
       Region 1xap A 369-371 disorder
       Region 1xap A 372-416 order
       Region 1xap A 417-421 disorder
Seq 176-421 Hetero tetramer : IID00083Complex
 Evidence X-RAY 4jyi B Reference
       Region 4jyi B 176-176 disorder
       Region 4jyi B 177-415 order
       Region 4jyi B 416-421 disorder
 Evidence X-RAY 4jyi A Reference
       Region 4jyi A 176-176 disorder
       Region 4jyi A 177-415 order
       Region 4jyi A 416-421 disorder
 Evidence X-RAY 4jyh B Reference
       Region 4jyh B 176-176 disorder
       Region 4jyh B 177-415 order
       Region 4jyh B 416-421 disorder
 Evidence X-RAY 4jyh A Reference
       Region 4jyh A 176-176 disorder
       Region 4jyh A 177-415 order
       Region 4jyh A 416-421 disorder
 Evidence X-RAY 4jyg B Reference
       Region 4jyg B 176-415 order
       Region 4jyg B 416-421 disorder
 Evidence X-RAY 4jyg A Reference
       Region 4jyg A 176-176 disorder
       Region 4jyg A 177-415 order
       Region 4jyg A 416-421 disorder
Seqphosphorylation
    77-77 Phosphoserine
 
Prediction
NeProc
Disorder 1-84,160-187,212-221,419-455
Order 85-159,188-211,222-418
ProS 24-28,160-163,184-187,452-455
AlphaFold
Disorder 1-74,161-179,416-455
Order 75-160,180-415
Pfam Hmmer
PF00105 86-161 4.6e-55
PF00104 233-413 6e-45
SEG 34-52 ,67-82 ,435-452
Function
Function in SwissProt
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (PubMed:12554770). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (PubMed:29021580). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment