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IID00442
 UniprotP16220
ProteinCyclic AMP-responsive element-binding protein 1
GeneCREB1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
327
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 102-135 Hetero trimer : IID00092Complex,IID00379Complex
 Evidence NMR 2lxt C Reference
       Region 2lxt C 102-135 order
       Region 2lxt C 102-106 high_rmsd
       Region 2lxt C 132-135 high_rmsd
Seq 269-327 Hetero dimer : Q3U182
 Evidence X-RAY 5zk1 A Reference
       Region 5zk1 A 269-270 disorder
       Region 5zk1 A 271-323 order
       Region 5zk1 A 324-327 disorder
Seq 269-327 Hetero tetramer : Q3U182
 Evidence X-RAY 5zko C Reference
       Region 5zko C 269-270 disorder
       Region 5zko C 271-323 order
       Region 5zko C 324-327 disorder
 Evidence X-RAY 5zko A Reference
       Region 5zko A 269-270 disorder
       Region 5zko A 271-323 order
       Region 5zko A 324-327 disorder
SeqProS possible 107-131 The rat pKID region (P15337, 100% identity) is disordered in the free state; The residues with high_rmsd are excluded from the ProS. Hetero trimer : IID00092Complex,IID00379Complex
       Region 2lxt C 102-135 order
Seqphosphorylation
    128-128 Phosphoserine
    119-119 Phosphoserine; by CaMK1
    257-257 Phosphoserine; by HIPK2
 
Prediction
NeProc
Disorder 1-274,327-327
Order 275-326
ProS 24-29,65-69,85-91,121-138,160-177,187-192,204-210,218-231,269-274
AlphaFold
Disorder 1-103,130-157,173-173,176-176,181-214,216-231,233-233,235-235,240-263,327-327
Order 104-129,158-172,174-175,177-180,215-215,232-232,234-234,236-239,264-326
Pfam Hmmer
PF02173 99-139 8.8e-23
PF00170 267-327 1e-21
SEG 93-108 ,138-145 ,148-160 ,278-292
Function
Function in SwissProt
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity).
Biological Process
Diagram with PDB data
CREB1/CRBBP/KMT2AAllosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core