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IID00442
 UniprotP16220
ProteinCyclic AMP-responsive element-binding protein 1
GeneCREB1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
341
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 116-149 Hetero trimer : IID00092Complex,IID00379Complex
 Evidence NMR 2lxt C Reference
       Region 2lxt C 116-149 order
       Region 2lxt C 116-120 high_rmsd
       Region 2lxt C 146-149 high_rmsd
SeqProS possible 121-145 The rat pKID region (P15337, 100% identity) is disordered in the free state. Hetero trimer : IID00092Complex,IID00379Complex
       Region 2lxt C 116-149 order
Seqphosphorylation
    128-128 Phosphoserine
    119-119 Phosphoserine; by CaMK1
    257-257 Phosphoserine; by HIPK2
 
Prediction
NeProc
Disorder 1-274,327-327
Order 275-326
ProS 24-29,65-69,85-91,121-138,160-177,187-192,204-210,218-231,269-274
AlphaFold
Disorder 1-103,130-157,173-173,176-176,181-214,216-231,233-233,235-235,240-263,327-327
Order 104-129,158-172,174-175,177-180,215-215,232-232,234-234,236-239,264-326
Pfam Hmmer
PF02173 99-139 8.8e-23
PF00170 267-327 1e-21
SEG 93-108 ,138-145 ,148-160 ,278-292
Function
Function in SwissProt
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Biological Process
Diagram with PDB data
CREB1/CRBBP/KMT2AAllosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core