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IID00445
UniprotP20749
ProteinB-cell lymphoma 3 protein
GeneBCL3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
454
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 127-367 Monomer :
 Evidence X-RAY 1k1b A Reference
       Region 1k1b A 127-132 disorder
       Region 1k1b A 133-360 order
       Region 1k1b A 361-367 disorder
 Evidence X-RAY 1k1a A Reference
       Region 1k1a A 127-132 disorder
       Region 1k1a A 133-360 order
       Region 1k1a A 361-367 disorder
Seqphosphorylation
    41-41 Phosphoserine
    374-374 Phosphoserine
    402-402 Phosphoserine; by GSK3
    406-406 Phosphoserine; by GSK3
 
Prediction
NeProc
Disorder 1-67,381-454
Order 68-380
ProS 1-67,381-450
AlphaFold
Disorder 1-119,361-454
Order 120-360
Pfam Hmmer
PF00023 134-170 0.00042
PF00023 171-203 1.5e-05
PF00023 241-273 6.3e-09
PF00023 275-307 2.6e-09
SEG 19-34 ,79-93 ,382-412 ,417-454
Function
Function in SwissProt
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).