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IID00446
 UniprotP25685
ProteinDnaJ homolog subfamily B member 1
GeneDNAJB1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
340
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-76 Monomer :
 Evidence NMR 1hdj A Reference
       Region 1hdj A 1-76 order
       Region 1hdj A 1-2 high_rmsd
       Region 1hdj A 73-76 high_rmsd
Seq 2-70 Hetero dimer : IID00349Complex,IID00366Complex
 Evidence X-RAY 4wb7 B This region is the chimera protein. Reference
       Region 4wb7 B 2-70 order
Seq 2-70 Hetero dimer : IID00349Complex,IID00366Complex
 Evidence X-RAY 4wb7 A This region is the chimera protein. Reference
       Region 4wb7 A 2-70 order
Seq 151-340 Hetero hexamer : IID00440Complex
 Evidence X-RAY 3agz B Reference
       Region 3agz B 151-158 disorder
       Region 3agz B 159-340 order
 Evidence X-RAY 3agz A Reference
       Region 3agz A 151-155 disorder
       Region 3agz A 156-340 order
Seq 158-340 Homo dimer :
 Evidence X-RAY 2qld A This structure is the putative peptide-binding complex. Reference
       Region 2qld A 158-161 disorder
       Region 2qld A 162-227 order
       Region 2qld A 228-230 disorder
       Region 2qld A 231-335 order
       Region 2qld A 336-340 disorder
 Evidence X-RAY 3agx B Reference
       Region 3agx B 161-164 disorder
       Region 3agx B 165-185 order
       Region 3agx B 186-203 disorder
       Region 3agx B 204-222 order
       Region 3agx B 223-232 disorder
       Region 3agx B 233-340 order
 Evidence X-RAY 3agx A Reference
       Region 3agx A 161-164 disorder
       Region 3agx A 165-340 order
Seq 161-340 Hetero pentamer : IID00440Complex
 Evidence X-RAY 3agy B Reference
       Region 3agy B 161-164 disorder
       Region 3agy B 165-340 order
 Evidence X-RAY 3agy A Reference
       Region 3agy A 161-164 disorder
       Region 3agy A 165-340 order
Seqphosphorylation
    307-307 Phosphothreonine
 
Prediction
NeProc
Disorder 74-190
Order 1-73,191-340
ProS 88-115,161-190
AlphaFold
Disorder 1-1,73-96,108-110,113-156
Order 2-72,97-107,111-112,157-340
Pfam Hmmer
PF00226 4-65 3.8e-38
PF01556 216-338 1.6e-14
SEG 68-91 ,130-141
Function
Function in SwissProt
Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).