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IID00447
 UniprotP30260
ProteinCell division cycle protein 27 homolog
GeneCDC27
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
824
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-180,447-824 Homo dimer :
 Evidence X-RAY 4rg7 B Reference
       Region 4rg7 B 1-5 disorder
       Region 4rg7 B 6-171 order
       Region 4rg7 B 172-180 disorder
       Region 4rg7 B 447-458 disorder
       Region 4rg7 B 459-681 order
       Region 4rg7 B 682-690 disorder
       Region 4rg7 B 691-768 order
       Region 4rg7 B 769-824 disorder
 Evidence X-RAY 4rg7 A Reference
       Region 4rg7 A 1-4 disorder
       Region 4rg7 A 5-171 order
       Region 4rg7 A 172-180 disorder
       Region 4rg7 A 447-455 disorder
       Region 4rg7 A 456-682 order
       Region 4rg7 A 683-690 disorder
       Region 4rg7 A 691-768 order
       Region 4rg7 A 769-824 disorder
Seq 1-180,447-824 Hetero trimer : Q96DE5
 Evidence X-RAY 4rg9 B Reference
       Region 4rg9 B 1-4 disorder
       Region 4rg9 B 5-171 order
       Region 4rg9 B 172-180 disorder
       Region 4rg9 B 447-455 disorder
       Region 4rg9 B 456-682 order
       Region 4rg9 B 683-690 disorder
       Region 4rg9 B 691-768 order
       Region 4rg9 B 769-824 disorder
 Evidence X-RAY 4rg9 A Reference
       Region 4rg9 A 1-5 disorder
       Region 4rg9 A 6-171 order
       Region 4rg9 A 172-180 disorder
       Region 4rg9 A 447-454 disorder
       Region 4rg9 A 455-682 order
       Region 4rg9 A 683-691 disorder
       Region 4rg9 A 692-768 order
       Region 4rg9 A 769-824 disorder
 Evidence X-RAY 4rg6 B Reference
       Region 4rg6 B 1-4 disorder
       Region 4rg6 B 5-171 order
       Region 4rg6 B 172-180 disorder
       Region 4rg6 B 447-454 disorder
       Region 4rg6 B 455-682 order
       Region 4rg6 B 683-690 disorder
       Region 4rg6 B 691-768 order
       Region 4rg6 B 769-824 disorder
 Evidence X-RAY 4rg6 A Reference
       Region 4rg6 A 1-4 disorder
       Region 4rg6 A 5-171 order
       Region 4rg6 A 172-180 disorder
       Region 4rg6 A 447-453 disorder
       Region 4rg6 A 454-682 order
       Region 4rg6 A 683-690 disorder
       Region 4rg6 A 691-768 order
       Region 4rg6 A 769-824 disorder
Seq 821-824 Hetero dimer : IID00516Complex
 Evidence X-RAY 3t1n D Reference
       Region 3t1n D 821-824 order
 Evidence X-RAY 3t1n C Reference
       Region 3t1n C 821-824 order
SeqProS verified 821-824 Hetero dimer : IID00516Complex
       Region 3t1n C 821-824 order
       Region 3t1n D 821-824 order
       Region 4rg7 A 769-824 disorder
Seqphosphorylation
    205-205 Phosphothreonine
    446-446 Phosphothreonine
    821-821 Phosphoserine
    435-435 Phosphoserine
    438-438 Phosphoserine
    209-209 Phosphothreonine
    426-426 Phosphoserine
    430-430 Phosphothreonine
    366-366 Phosphothreonine
    379-379 Phosphoserine
    386-386 Phosphoserine
    313-313 Phosphothreonine
    339-339 Phosphoserine
    244-244 Phosphothreonine
    291-291 Phosphoserine
 
Prediction
NeProc
Disorder 178-450,785-824
Order 1-177,451-784
ProS 206-214,221-225,240-251,257-266,301-306,415-431,819-824
AlphaFold
Disorder 1-3,170-450,452-452,770-824
Order 4-169,451-451,453-769
Pfam Hmmer
PF00515 567-600 1.1e-08
PF00515 601-634 5.5e-07
PF00515 635-668 2.7e-10
PF00515 669-702 1.2e-05
SEG 348-361
Function
Function in SwissProt
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.