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IID00450
 UniprotP35226
ProteinPolycomb complex protein BMI-1
GeneBMI1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
326
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-109 Hetero trimer : Q99496
 Evidence X-RAY 3rpg B Reference
       Region 3rpg B 1-2 disorder
       Region 3rpg B 3-101 order
       Region 3rpg B 102-109 disorder
Seq 2-109 Hetero dodecamer : IID50147Complex,P61077,Q99496
 Evidence X-RAY 4r8p M Reference
       Region 4r8p M 2-5 disorder
       Region 4r8p M 6-102 order
       Region 4r8p M 103-109 disorder
 Evidence X-RAY 4r8p K Reference
       Region 4r8p K 2-2 disorder
       Region 4r8p K 3-107 order
       Region 4r8p K 108-109 disorder
Seq 5-101 Hetero dimer : Q99496
 Evidence X-RAY 2h0d A Reference
       Region 2h0d A 5-101 order
Seq 121-235 Homo dimer :
 Evidence X-RAY 5fr6 A Reference
       Region 5fr6 A 121-126 disorder
       Region 5fr6 A 127-138 order
       Region 5fr6 A 139-160 disorder
       Region 5fr6 A 161-231 order
       Region 5fr6 A 232-235 disorder
Seq 121-235 Monomer : Q9QWH1
 Evidence NMR 2na1 A Reference
       Region 2na1 A 121-231 order
       Region 2na1 A 121-125 high_rmsd
       Region 2na1 A 152-155 high_rmsd
       Region 2na1 A 232-235 disorder
 
Prediction
NeProc
Disorder 1-4,105-156,232-326
Order 5-104,157-231
ProS 105-156,316-319
AlphaFold
Disorder 1-3,105-108,120-121,143-159,232-326
Order 4-104,109-119,122-142,160-231
Pfam Hmmer
PF00097 18-56 2.1e-11
SEG 266-278 ,315-325
Function
Function in SwissProt
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).